Current Role of PET CT in Staging and Management of Penile Cancers
Abstract
:1. Introduction
2. Materials and Methods
3. Results
3.1. Role of PET-CT for T Staging in Penile Cancer
3.2. Role of PET-CT in the Management of Clinically Node-Negative PeCas
3.3. Role of PET-CT in the Management of Clinically Node-Positive PeCas
3.4. Role of PET CT in the Management of Pelvic Lymph Nodes and Distant Metastasis
3.5. Role of PET CT in Follow-Up after Treatment
3.6. Implications for Further Research
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Conflicts of Interest
References
- Fu, L.; Tian, T.; Yao, K.; Chen, X.-F.; Luo, G.; Gao, Y.; Lin, Y.-F.; Wang, B.; Sun, Y.; Zheng, W.; et al. Global Pattern and Trends in Penile Cancer Incidence: Population-Based Study. JMIR Public Health Surveill. 2022, 8, e34874. [Google Scholar] [CrossRef] [PubMed]
- Moch, H.; Cubilla, A.L.; Humphrey, P.A.; Reuter, V.E.; Ulbright, T.M. The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours. Eur. Urol. 2016, 70, 93–105. [Google Scholar] [CrossRef] [PubMed]
- Hogan, D.; Norton, S.M.; Patterson, K.; Murphy, A.; O‘Neill, B.; Daly, P.; Cullen, I.M. Phallus preservation and reconstruction: 5-year outcomes of national penile cancer centralisation in the Republic of Ireland. Surgeon 2024. [Google Scholar] [CrossRef] [PubMed]
- Brouwer, O.R.; Albersen, M.; Parnham, A.; Protzel, C.; Pettaway, C.A.; Ayres, B.; Antunes-Lopes, T.; Barreto, L.; Campi, R.; Crook, J.; et al. European Association of Urology-American Society of Clinical Oncology Collaborative Guideline on Penile Cancer: 2023 Update. Eur. Urol. 2023, 83, 548–560. [Google Scholar] [CrossRef] [PubMed]
- Ottenhof, S.R.; Leone, A.R.; Horenblas, S.; Spiess, P.E.; Vegt, E. Advancements in staging and imaging for penile cancer. Curr. Opin. Urol. 2017, 27, 612–620. [Google Scholar] [CrossRef] [PubMed]
- Ottenhof, S.R.; Djajadiningrat, R.S.; Versleijen, M.W.J.; Donswijk, M.L.; van der Noort, V.; Brouwer, O.R.; Graafland, N.M.; Vegt, E.; Horenblas, S. F-18 Fluorodeoxyglucose Positron Emission Tomography with Computed Tomography Has High Diagnostic Value for Pelvic and Distant Staging in Patients with High-risk Penile Carcinoma. Eur. Urol. Focus 2022, 8, 98–104. [Google Scholar] [CrossRef]
- Reske, S.N.; Kotzerke, J. FDG-PET for clinical use. Results of the 3rd German Interdisciplinary Consensus Conference, “Onko-PET III”, 21 July and 19 September 2000. Eur. J. Nucl. Med. 2001, 28, 1707–1723. [Google Scholar] [CrossRef] [PubMed]
- Fletcher, J.W.; Djulbegovic, B.; Soares, H.P.; Siegel, B.A.; Lowe, V.J.; Lyman, G.H.; Coleman, R.E.; Wahl, R.; Paschold, J.C.; Avril, N.; et al. Recommendations on the use of 18F-FDG PET in oncology. J. Nucl. Med. 2008, 49, 480–508. [Google Scholar] [CrossRef]
- Bozzini, G.; Provenzano, M.; Otero, J.R.; Margreiter, M.; Cruz, E.G.; Osmolorskij, B.; Verze, P.; Pavan, N.; Sanguedolce, F.; Buffi, N.; et al. Role of Penile Doppler US in the Preoperative Assessment of Penile Squamous Cell Carcinoma Patients: Results From a Large Prospective Multicenter European Study. Urology 2016, 90, 131–135. [Google Scholar] [CrossRef]
- Salazar, A.; Júnior, E.P.; Salles, P.G.O.; Silva-Filho, R.; Reis, E.A.; Mamede, M. 18F-FDG PET/CT as a prognostic factor in penile cancer. Eur. J. Nucl. Med. 2019, 46, 855–863. [Google Scholar] [CrossRef] [PubMed]
- Ottenhof, S.R.; Vegt, E. The role of PET/CT imaging in penile cancer. Transl. Androl. Urol. 2017, 6, 833–838. [Google Scholar] [CrossRef] [PubMed]
- De Vries, H.M.; Brouwer, O.R.; Heijmink, S.; Horenblas, S.; Vegt, E. Recent developments in penile cancer imaging. Curr. Opin. Urol. 2019, 29, 150–155. [Google Scholar] [CrossRef] [PubMed]
- Musi, G.; Molinari, F.; Mistretta, F.A.; Piccinelli, M.L.; Guzzo, S.; Tozzi, M.; Lievore, E.; Blezien, O.; Fontana, M.; Cioffi, A.; et al. Penile-Sparing Surgery for Tumour Recurrence after Previous Glansectomy/Partial Penectomy: Treatment Feasibility and Oncological Outcomes. Cancers 2023, 15, 4807. [Google Scholar] [CrossRef] [PubMed]
- Hughes, B.; Leijte, J.; Shabbir, M.; Watkin, N.; Horenblas, S. Non-invasive and minimally invasive staging of regional lymph nodes in penile cancer. World J. Urol. 2009, 27, 197–203. [Google Scholar] [CrossRef] [PubMed]
- Wood, H.M.; Angermeier, K.W. Anatomic considerations of the penis, lymphatic drainage, and biopsy of the sentinel node. Urol. Clin. N. Am. 2010, 37, 327–334. [Google Scholar] [CrossRef] [PubMed]
- Bloom, J.B.; Stern, M.; Patel, N.H.; Zhang, M.; Phillips, J.L. Detection of lymph node metastases in penile cancer. Transl. Androl. Urol. 2018, 7, 879–886. [Google Scholar] [CrossRef]
- Lucchesi, F.R.; Reis, R.B.; Faria, E.F.; Machado, R.D.; Rossini, R.R.; Borregales, L.D.; Silva, G.E.B.; Muglia, V.F. Incremental value of MRI for preoperative penile cancer staging. J. Magn. Reson. Imaging 2017, 45, 118–124. [Google Scholar] [CrossRef] [PubMed]
- Drager, D.L.; Heuschkel, M.; Protzel, C.; Erbersdobler, A.; Krause, B.J.; Hakenberg, O.W.; Schwarzenbock, S.M. [18F]FDG PET/CT for assessing inguinal lymph nodes in patients with penile cancer-correlation with histopathology after inguinal lymphadenectomy. Nuklearmedizin 2018, 57, 26–30. [Google Scholar] [CrossRef] [PubMed]
- Sadeghi, R.; Gholami, H.; Zakavi, S.R.; Kakhki, V.R.; Horenblas, S. Accuracy of 18F-FDG PET/CT for diagnosing inguinal lymph node involvement in penile squamous cell carcinoma: Systematic review and meta-analysis of the literature. Clin. Nucl. Med. 2012, 37, 436–441. [Google Scholar] [CrossRef]
- Kroon, B.K.; Horenblas, S.; Deurloo, E.E.; Nieweg, O.E.; Teertstra, H.J. Ultrasonography-guided fine-needle aspiration cytology before sentinel node biopsy in patients with penile carcinoma. BJU Int. 2005, 95, 517–521. [Google Scholar] [CrossRef]
- Jakobsen, J.K.; Alslev, L.; Ipsen, P.; Costa, J.C.; Krarup, K.P.; Sommer, P.; Nerstrøm, H.; Toft, B.G.; Høyer, S.; Bouchelouche, K.; et al. DaPeCa-3: Promising results of sentinel node biopsy combined with 18F-fluorodeoxyglucose positron emission tomography/computed tomography in clinically lymph node-negative patients with penile cancer—A national study from Denmark. BJU Int. 2016, 118, 102–111. [Google Scholar] [CrossRef] [PubMed]
- KleinJan, G.H.; van Werkhoven, E.; Berg, N.S.v.D.; Karakullukcu, M.B.; Zijlmans, H.J.M.A.A.; van der Hage, J.A.; van de Wiel, B.A.; Buckle, T.; Klop, W.M.C.; Horenblas, S.; et al. The best of both worlds: A hybrid approach for optimal pre- and intraoperative identification of sentinel lymph nodes. Eur. J. Nucl. Med. 2018, 45, 1915–1925. [Google Scholar] [CrossRef]
- van Westreenen, H.; Westerterp, M.; Bossuyt, P.; Pruim, J.; Sloof, G.; van Lanschot, J.; Groen, H.; Plukker, J. Systematic review of the staging performance of18F-fluorodeoxyglucose positron emission tomography in esophageal cancer. J. Clin. Oncol. 2004, 22, 3805–3812. [Google Scholar] [CrossRef]
- Peyraud, F.; Allenet, C.; Gross-Goupil, M.; Domblides, C.; Lefort, F.; Daste, A.; Yacoub, M.; Haaser, T.; Ferretti, L.; Robert, G.; et al. Current management and future perspectives of penile cancer: An updated review. Cancer Treat. Rev. 2020, 90, 102087. [Google Scholar] [CrossRef] [PubMed]
- Lee, S.W.; Kim, S.-J. Diagnostic Performance of 18F-FDG PET/CT for Lymph Node Staging in Penile Cancer. Clin. Nucl. Med. 2022, 47, 402–408. [Google Scholar] [CrossRef] [PubMed]
- Chu, K.P.; Murphy, J.D.; La, T.H.; Krakow, T.E.; Iagaru, A.; Graves, E.E.; Hsu, A.; Maxim, P.G.; Loo, B.; Chang, D.T.; et al. Prognostic value of metabolic tumor volume and velocity in predicting head-and-neck cancer outcomes. Int. J. Radiat. Oncol. 2012, 83, 1521–1527. [Google Scholar] [CrossRef] [PubMed]
- Yoo Ie, R.; Chung, S.K.; Park, H.L.; Choi, W.H.; Kim, Y.K.; Lee, K.Y.; Wang, Y.P. Prognostic value of SUVmax and metabolic tumor volume on 18F-FDG PET/CT in early stage non-small cell lung cancer patients without LN metastasis. Biomed. Mater. Eng. 2014, 24, 3091–3103. [Google Scholar] [CrossRef]
- Zhang, S.; Li, W.; Liang, F. Clinical value of fluorine-18 2-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography in penile cancer. Oncotarget 2016, 7, 48600–48606. [Google Scholar] [CrossRef]
- Ottenhof, S.R.; de Vries, H.M.; Doodeman, B.; Vrijenhoek, G.L.; van der Noort, V.; Donswijk, M.L.; de Feijter, J.M.; Schaake, E.E.; Horenblas, S.; Brouwer, O.R.; et al. A Prospective Study of Chemoradiotherapy as Primary Treatment in Patients With Locoregionally Advanced Penile Carcinoma. Int. J. Radiat. Oncol. Biol. Phys. 2023, 117, 139–147. [Google Scholar] [CrossRef]
- Peng, F. Recent Advances in Cancer Imaging with 64CuCl2 PET/CT. Nucl. Med. Mol. Imaging 2022, 56, 80–85. [Google Scholar] [CrossRef]
- Loktev, A.; Lindner, T.; Mier, W.; Debus, J.; Altmann, A.; Jäger, D.; Giesel, F.; Kratochwil, C.; Barthe, P.; Roumestand, C.; et al. A Tumor-Imaging Method Targeting Cancer-Associated Fibroblasts. J. Nucl. Med. 2018, 59, 1423–1429. [Google Scholar] [CrossRef] [PubMed]
- Kratochwil, C.; Flechsig, P.; Lindner, T.; Abderrahim, L.; Altmann, A.; Mier, W.; Adeberg, S.; Rathke, H.; Röhrich, M.; Winter, H.; et al. 68Ga-FAPI PET/CT: Tracer Uptake in 28 Different Kinds of Cancer. J. Nucl. Med. 2019, 60, 801–805. [Google Scholar] [CrossRef] [PubMed]
- Giesel, F.L.; Kratochwil, C.; Lindner, T.; Marschalek, M.M.; Loktev, A.; Lehnert, W.; Debus, J.; Jäger, D.; Flechsig, P.; Altmann, A.; et al. 68Ga-FAPI PET/CT: Biodistribution and Preliminary Dosimetry Estimate of 2 DOTA-Containing FAP-Targeting Agents in Patients with Various Cancers. J. Nucl. Med. 2019, 60, 386–392. [Google Scholar] [CrossRef] [PubMed]
- Chen, W.-K.; Wu, Z.-G. Adding radiotherapy based on chemotherapy can improve cancer-specific survival in N3 penile cancer: A SEER-based study. Transl. Androl. Urol. 2020, 9, 2587–2595. [Google Scholar] [CrossRef] [PubMed]
- Chahoud, J.; Kohli, M.; Spiess, P.E. Management of Advanced Penile Cancer. Mayo Clin. Proc. 2021, 96, 720–732. [Google Scholar] [CrossRef] [PubMed]
- Clark, P.E.; Spiess, P.E.; Agarwal, N.; Biagioli, M.C.; Eisenberger, M.A.; Greenberg, R.E.; Herr, H.W.; Inman, B.A.; Kuban, D.A.; Kuzel, T.M.; et al. Penile cancer: Clinical Practice Guidelines in Oncology. J. Natl. Compr. Canc. Netw. 2013, 11, 594–615. [Google Scholar]
- Campbell, R.A.; Slopnick, E.A.; Ferry, E.K.; Zhu, H.; Kim, S.P.; Abouassaly, R. Disparity between pre-existing management of penile cancer and NCCN guidelines. Urol. Oncol. Semin. Orig. Investig. 2017, 35, 531.e9–531.e14. [Google Scholar] [CrossRef]
- Pettaway, C.A.; Nicholson, S.; Spiess, P.E.; Pagliaro, L.C.; Watkin, N.; Barber, J.; Carducci, M.A.; Trabulsi, E.J.; Crook, J.M.; Rosen, M.A.; et al. The international penile advanced cancer trial (InPACT): The first phase III trial for squamous carcinoma of the penis with regional lymph node metastases. J. Clin. Oncol. 2022, 40 (Suppl. S6), TPS7-TPS. [Google Scholar] [CrossRef]
- Bandini, M.; Albersen, M.; Chipollini, J.; Pederzoli, F.; Zhu, Y.; Ye, D.; Ornellas, A.A.; Watkin, N.; Ager, M.; Hakenberg, O.W.; et al. Optimising the selection of candidates for neoadjuvant chemotherapy amongst patients with node-positive penile squamous cell carcinoma. BJU Int. 2020, 125, 867–875. [Google Scholar] [CrossRef]
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Mirvald, C.; Garaz, R.; Sinescu, I.; Preda, A.; Labanaris, A.; Yossepowitch, O.; Tsaur, I.; Surcel, C. Current Role of PET CT in Staging and Management of Penile Cancers. J. Clin. Med. 2024, 13, 4879. https://doi.org/10.3390/jcm13164879
Mirvald C, Garaz R, Sinescu I, Preda A, Labanaris A, Yossepowitch O, Tsaur I, Surcel C. Current Role of PET CT in Staging and Management of Penile Cancers. Journal of Clinical Medicine. 2024; 13(16):4879. https://doi.org/10.3390/jcm13164879
Chicago/Turabian StyleMirvald, Cristian, Radion Garaz, Ioanel Sinescu, Adrian Preda, Apostolos Labanaris, Ofer Yossepowitch, Igor Tsaur, and Cristian Surcel. 2024. "Current Role of PET CT in Staging and Management of Penile Cancers" Journal of Clinical Medicine 13, no. 16: 4879. https://doi.org/10.3390/jcm13164879