Does Indocyanine Green Utilization during Esophagectomy Prevent Anastomotic Leaks? Systematic Review and Meta-Analysis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Eligibility Criteria
2.2. Data Extraction
2.3. Outcomes
2.4. Quality Assessment
2.5. Statistical Analysis
3. Results
3.1. Systematic Review
3.2. Meta-Analysis: Primary Outcome
3.3. Meta-Analysis: Secondary Outcomes
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Appendix A. Search Strategy
References
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Author, Year | Study Design | No. Pts | ICG | Gender (M) | BMI (kg/m2) | Age (Years) | NT | Histology | Tumour Stage | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
AdK | SCC | Other | 1 | 2 | 3 | 4 | |||||||||
Campbell et al., 2015 [31] | Ret | 90 | ICG | 30 | 27 | NR | 64 (44–81) | 3 | 27 | 1 | 2 | NR | NR | NR | NR |
nICG | 60 | 47 | NR | 62 (22–76) | 34 | 48 | 7 | 4 | NR | NR | NR | NR | |||
Hodari et al., 2015 [32] | Ret | 54 | ICG | 39 | NR | NR | NR | NR | NR | NR | NR | NR | NR | NR | NR |
nICG | 15 | NR | NR | NR | NR | NR | NR | NR | NR | NR | NR | NR | |||
Karampinis et al., 2017 [33] | Ret | 88 | ICG | 33 | 24 | 28.8 ± 4.2 | 65.7 ± 8.5 | 25 | 25 | 7 | 1 | 7 | 10 | 12 | 4 |
nICG | 55 | 41 | 25.8 ± 4.3 | 60.5 ± 8.5 | 44 | NR | NR | NR | 17 | 25 | 10 | 3 | |||
Dalton et al., 2017 [34] | Pros | 40 | ICG | 20 | 16 | 26.4 ± 4.9 | 61.8 ± 12.8 | 17 | NR | NR | NR | NR | NR | NR | NR |
nICG | 20 | 16 | 26.3 ± 4.1 | 66.2 ± 8.0 | 19 | NR | NR | NR | NR | NR | NR | NR | |||
Ohi et al., 2017 [35] | Ret | 120 | ICG | 59 | NR | NR | 68 (63–74) | NR | NR | NR | NR | NR | NR | NR | NR |
nICG | 61 | NR | NR | 68 (63–74) | NR | NR | NR | NR | NR | NR | NR | NR | |||
Noma et al., 2018 [36] | Ret, PS | 136 | ICG | 68 | 56 | 22.1 ± 2.7 | 65.3 ± 8.1 | 39 | 3 | 62 | 3 | 33 | 17 | 13 | 5 |
nICG | 68 | 59 | 22.1 ± 3.4 | 64.3 ± 7.5 | 37 | 2 | 64 | 2 | 31 | 10 | 25 | 2 | |||
Luo et al., 2020 [37] | Ret | 192 | ICG | 86 | 74 | 22.6 ± 2.9 | 65.8 ± 6.5 | 14 | 2 | 84 | 0 | 28 | 22 | 34 | 2 |
nICG | 106 | 97 | 22.1 ± 3.3 | 64.9 ± 6.9 | 12 | 0 | 101 | 5 | 32 | 26 | 42 | 6 | |||
Shishido et al., 2022 [38] | Pros, PS | 66 | ICG | 33 | 27 | 21.9 ± 3.3 | 67 (63–73) | 17 | 2 | 30 | 1 | 13 | 10 | 10 | 0 |
nICG | 33 | 30 | 21.8 ± 3.1 | 65 (61–73) | 17 | 2 | 30 | 1 | 16 | 5 | 12 | 0 | |||
Banks et al., 2023 [39] | Ret | 181 | ICG | 59 | 46 | 25.9 ± 4.9 | 66.9 ± 8.6 | 52 | 49 | 9 | 1 | 20 | 12 | 20 | 7 |
nICG | 122 | 98 | 27.3 ± 5.2 | 64.4 ± 10.2 | 114 | 107 | 14 | 1 | 40 | 30 | 29 | 23 | |||
LeBlanc et al., 2023 [40] | Pros | 312 | ICG | 61 | 48 | 27.5 ± 5.9 | 70 (51–82) | 47 | 48 | 10 | 3 | NR | NR | NR | NR |
nICG | 251 | 202 | 27.3 ± 6.6 | 67 (30–91) | 199 | 206 | 33 | 12 | NR | NR | NR | NR | |||
Nguyen et al., 2024 [41] | Ret | 120 | ICG | 88 | 82 | 20.3 ± 2.9 | 62.5 ± 8.1 | 25 | 6 | 81 | 1 | NR | NR | NR | NR |
nICG | 32 | 32 | 18.9 ± 3.1 | 63.3 ± 8.1 | 8 | 2 | 30 | 0 | NR | NR | NR | NR |
Author, Year | ICG | Procedure | Thoracic Approach | Anastomosis | ||||||
---|---|---|---|---|---|---|---|---|---|---|
IL | MK | O | TS | R | HS | CS | LS | |||
Campbell et al., 2015 [31] | ICG | 30 | 30 | 0 | 2 | 28 | 0 | 0 | 30 | 0 |
nICG | 60 | 60 | 0 | 6 | 54 | 0 | 0 | 60 | 0 | |
Hodari et al., 2015 [32] | ICG | 39 | 39 | 0 | 0 | 0 | 39 | 0 | 0 | 39 |
nICG | 15 | 15 | 0 | 0 | 0 | 15 | 0 | 0 | 15 | |
Karampinis et al., 2017 [33] | ICG | 33 | 25 | 8 | 0 | 33 | 0 | 8 | 25 | 0 |
nICG | 55 | 38 | 17 | 0 | 55 | 0 | 17 | 38 | 0 | |
Dalton et al., 2017 [34] | ICG | 20 | 20 | 0 | 0 | 20 | 0 | 0 | 20 | 0 |
nICG | 20 | 20 | 0 | 0 | 20 | 0 | 0 | 20 | 0 | |
Ohi et al., 2017 [35] | ICG | 59 | NR | NR | NR | NR | NR | NR | NR | NR |
nICG | 61 | NR | NR | NR | NR | NR | NR | NR | NR | |
Noma et al., 2018 [36] | ICG | 68 | 0 | 68 | 8 | 60 | 0 | 14 | 49 | 5 |
nICG | 68 | 0 | 68 | 21 | 47 | 0 | 14 | 50 | 6 | |
Luo et al., 2020 [37] | ICG | 86 | 0 | 86 | NR | NR | NR | 0 | 86 | 0 |
nICG | 106 | 0 | 106 | NR | NR | NR | 0 | 106 | 0 | |
Shishido et al., 2022 [38] | ICG | 33 | 33 | 0 | 0 | 30 | 3 | 0 | 33 | 0 |
nICG | 33 | 33 | 0 | 0 | 33 | 0 | 0 | 33 | 0 | |
Banks et al., 2023 [39] | ICG | 59 | 59 | 0 | 0 | 59 | 0 | 0 | 59 | 0 |
nICG | 122 | 122 | 0 | 0 | 122 | 0 | 0 | 122 | 0 | |
LeBlanc et al., 2023 [40] | ICG | 61 | NR | NR | 0 | 0 | 61 | NR | NR | NR |
nICG | 251 | NR | NR | 0 | 0 | 251 | NR | NR | NR | |
Nguyen et al., 2024 [41] | ICG | 88 | 0 | 88 | 0 | 88 | 0 | NR | NR | NR |
nICG | 32 | 0 | 32 | 0 | 32 | 0 | NR | NR | NR |
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Sozzi, A.; Bona, D.; Yeow, M.; Habeeb, T.A.A.M.; Bonitta, G.; Manara, M.; Sangiorgio, G.; Biondi, A.; Bonavina, L.; Aiolfi, A. Does Indocyanine Green Utilization during Esophagectomy Prevent Anastomotic Leaks? Systematic Review and Meta-Analysis. J. Clin. Med. 2024, 13, 4899. https://doi.org/10.3390/jcm13164899
Sozzi A, Bona D, Yeow M, Habeeb TAAM, Bonitta G, Manara M, Sangiorgio G, Biondi A, Bonavina L, Aiolfi A. Does Indocyanine Green Utilization during Esophagectomy Prevent Anastomotic Leaks? Systematic Review and Meta-Analysis. Journal of Clinical Medicine. 2024; 13(16):4899. https://doi.org/10.3390/jcm13164899
Chicago/Turabian StyleSozzi, Andrea, Davide Bona, Marcus Yeow, Tamer A. A. M. Habeeb, Gianluca Bonitta, Michele Manara, Giuseppe Sangiorgio, Antonio Biondi, Luigi Bonavina, and Alberto Aiolfi. 2024. "Does Indocyanine Green Utilization during Esophagectomy Prevent Anastomotic Leaks? Systematic Review and Meta-Analysis" Journal of Clinical Medicine 13, no. 16: 4899. https://doi.org/10.3390/jcm13164899