The Role of Vitamin D Metabolism Genes and Their Genomic Background in Shaping Cyclosporine A Dosage Parameters after Kidney Transplantation
Abstract
:1. Introduction
2. Materials and Methods
2.1. Selection and Characteristics of the Study Group
2.2. Isolation of Samples
2.3. Statistical Analysis
3. Results
Polymorphism | Rank 1 |
---|---|
rs231775 CTLA4 | 100 |
rs602662 FUT2 | 94 |
rs2282679 GC | 90 |
rs1800896 IL10 | 89 |
rs1800795 IL6 | 88 |
rs8175347 UGT1A1*28 | 86 |
rs4654748 NBPF3 | 83 |
rs2032582 MDR | 80 |
rs1045642 MDR | 79 |
rs2069762 IL2 | 76 |
rs10741657 CYP2R1 | 72 |
rs1800468 TGFB | 63 |
rs1800629 TNF-alfa | 53 |
rs12272004 | 53 |
rs33972313 SLC23A1 | 41 |
rs2740574 CYP3A4 | 22 |
- Leaf ID 6: rs2282679 CA, IL 10-1082A>G RS1800896 GA or GG, MDR2677G>T RS2032582 GT
- Leaf ID 5: rs2282679 CA, IL10-1082A>G RS1800896 AA
- Leaf ID 10: rs2282679 CC or AA, rs602662 FUT2 GG or AG, IL10-1082A>G RS1800896 AA
- Leaf ID 9: rs2282679 CC or CA, rs602662 FUT2 AA
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Variable | Mean | Median | Minimum | Maximum | Std. Dev. | Conf. SD −95% | Conf. SD +95% | Standard Error |
---|---|---|---|---|---|---|---|---|
WBC | 7.67 | 7.32 | 1.85 | 17.31 | 2.43 | 2.20 | 2.71 | 0.18 |
RBC | 4.23 | 4.21 | 2.86 | 5.53 | 0.59 | 0.53 | 0.65 | 0.04 |
HGB | 12.83 | 12.80 | 8.80 | 17.10 | 1.70 | 1.54 | 1.90 | 0.13 |
HCT | 37.89 | 37.80 | 27.00 | 51.40 | 4.81 | 4.35 | 5.37 | 0.36 |
PLT | 222.11 | 213.00 | 45.00 | 467.00 | 71.46 | 64.69 | 79.82 | 5.39 |
Na | 141.16 | 141.00 | 120.00 | 149.00 | 3.57 | 3.23 | 3.99 | 0.27 |
K | 4.17 | 4.17 | 3.14 | 5.42 | 0.44 | 0.40 | 0.49 | 0.03 |
bilirubin | 0.61 | 0.54 | 0.16 | 1.69 | 0.29 | 0.26 | 0.32 | 0.02 |
BUN | 29.98 | 26.45 | 8.30 | 71.10 | 13.03 | 11.80 | 14.56 | 0.98 |
creatinine | 1.61 | 1.44 | 0.67 | 4.31 | 0.64 | 0.58 | 0.71 | 0.05 |
uric acid | 6.98 | 7.00 | 3.70 | 10.90 | 1.48 | 1.34 | 1.66 | 0.11 |
AlAT | 19.33 | 16.00 | 3.00 | 73.00 | 11.15 | 10.09 | 12.45 | 0.84 |
AspAT | 20.66 | 18.00 | 10.00 | 70.00 | 8.91 | 8.07 | 9.95 | 0.67 |
total CH | 187.81 | 185.00 | 80.00 | 344.00 | 39.06 | 35.32 | 43.71 | 2.99 |
HDL | 62.99 | 60.60 | 27.60 | 118.20 | 20.12 | 17.83 | 23.09 | 1.86 |
LDL | 95.69 | 91.00 | 36.00 | 239.00 | 36.48 | 32.32 | 41.90 | 3.39 |
TG | 142.87 | 127.00 | 48.00 | 404.00 | 66.46 | 58.90 | 76.26 | 6.14 |
lipids total | 639.37 | 622.00 | 430.00 | 1183.00 | 133.75 | 118.53 | 153.49 | 12.37 |
Variable | Mean | Median | Minimum | Maximum | Std. Dev. | Conf. SD −95% | Conf. SD +95% | Standard Error |
---|---|---|---|---|---|---|---|---|
Age [y] | 54.27 | 55.00 | 22.00 | 82.00 | 12.41 | 11.23 | 13.85 | 0.93 |
Weight [kg] | 78.89 | 78.00 | 40.00 | 139.00 | 17.25 | 15.62 | 19.27 | 1.30 |
Heihght [cm] | 169.59 | 169.00 | 150.00 | 193.00 | 9.43 | 8.54 | 10.54 | 0.71 |
BMI [kg/m2] | 27.34 | 26.37 | 17.31 | 42.90 | 5.12 | 4.63 | 5.71 | 0.38 |
Time from KTx [m] | 10.38 | 10.00 | 1.00 | 27.00 | 6.24 | 5.65 | 6.97 | 0.47 |
Dose [mg] | 171.30 | 150.00 | 50.00 | 500.00 | 61.27 | 55.48 | 68.41 | 4.60 |
Concentration [ng/mL] | 116.37 | 113.00 | 2.00 | 315.90 | 48.03 | 43.49 | 53.63 | 3.61 |
Concentration/dose | 0.72 | 0.67 | 0.01 | 1.75 | 0.28 | 0.25 | 0.31 | 0.02 |
Genotype | rs2282679GC CA rs1800896 IL10 AA (Leaf ID 5) | rs1800896 IL10 GG GA rs2032582 MDR2677bGT rs2282679 GC CC CA (Leaf ID 6) | rs602662 FUT2 AA rs2282679 GC (Leaf ID 9) |
---|---|---|---|
rs2282679 GC CA rs1800896 IL10 AA | p = 0.08 | p = 0.54 | |
(Leaf ID 5) rs1800896 IL10 GGGA rs2032582 MDR2677bGT | p = 0.08 | p = 0.006 | |
rs2282679 GC CC or CA (Leaf ID 6) rs602662 FUT2 AA | p = 0.57 | p = 0.006 | |
rs2282679 GC (Leaf ID 9) rs602662 FUT2 GG AG rs1800896 IL10 AA (Leaf ID 10) | p = 0.62 | p = 0.73 | p = 0.08 |
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Kotowska, K.; Wojciuk, B.; Sieńko, J.; Bogacz, A.; Stukan, I.; Drożdżal, S.; Czerny, B.; Tejchman, K.; Trybek, G.; Machaliński, B.; et al. The Role of Vitamin D Metabolism Genes and Their Genomic Background in Shaping Cyclosporine A Dosage Parameters after Kidney Transplantation. J. Clin. Med. 2024, 13, 4966. https://doi.org/10.3390/jcm13164966
Kotowska K, Wojciuk B, Sieńko J, Bogacz A, Stukan I, Drożdżal S, Czerny B, Tejchman K, Trybek G, Machaliński B, et al. The Role of Vitamin D Metabolism Genes and Their Genomic Background in Shaping Cyclosporine A Dosage Parameters after Kidney Transplantation. Journal of Clinical Medicine. 2024; 13(16):4966. https://doi.org/10.3390/jcm13164966
Chicago/Turabian StyleKotowska, Katarzyna, Bartosz Wojciuk, Jerzy Sieńko, Anna Bogacz, Iga Stukan, Sylwester Drożdżal, Bogusław Czerny, Karol Tejchman, Grzegorz Trybek, Bogusław Machaliński, and et al. 2024. "The Role of Vitamin D Metabolism Genes and Their Genomic Background in Shaping Cyclosporine A Dosage Parameters after Kidney Transplantation" Journal of Clinical Medicine 13, no. 16: 4966. https://doi.org/10.3390/jcm13164966