Efficacy of Percutaneous Laser Disc Decompression (PLDD) Combined with an Oral Food Supplement for Lumbar Disc Herniation
Abstract
:1. Introduction
2. Materials
3. Surgical Technique
4. Statistical Analysis
5. Results
5.1. Patients’ Population
5.2. Preoperative Clinical Data
5.3. Postoperative Data
6. Discussion
7. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
- Urits, I.; Burshtein, A.; Sharma, M.; Testa, L.; Gold, P.A.; Orhurhu, V.; Viswanath, O.; Jones, M.R.; Sidransky, M.A.; Spektor, B.; et al. Low Back Pain, a Comprehensive Review: Pathophysiology, Diagnosis, and Treatment. Curr. Pain Headache Rep. 2019, 23, 23. [Google Scholar] [CrossRef] [PubMed]
- Anderssen, G.B.J.; Frymoyer, J.W. (Eds.) The epidemiology of spinal disorders. In The Adult Spine: Principles and Practice; Raven Press: New York, NY, USA, 1997; pp. 93–141. [Google Scholar]
- Dewing, C.B.; Provencher, M.T.; Riffenburgh, R.H.; Kerr, S.; Manos, R.E. The outcomes of lumbar microdiscectomy in a young, active population: Correlation by herniation type and level. Spine 2008, 1, 33–38. [Google Scholar] [CrossRef]
- Schenk, B.; Brouwer, P.A.; van Buchem, M.A. Experimental basis of percutaneous laser disc decompression (PLDD): A review of literature. Lasers Med. Sci. 2006, 4, 245–249. [Google Scholar] [CrossRef] [PubMed]
- Choy, D.; Ascher, P.W.; Ranu, H.; Saddekni, S.; Alkaitis, D.; Liebler, W.; Hughes, J.; Diwan, S.; Altman, P. Percutaneous laser disc decompression A new therapeutic modality. Spine 1992, 8, 949–956. [Google Scholar] [CrossRef] [PubMed]
- Brouwer, P.A.; Peul, W.C.; Brand, R.; Arts, M.P.; Koes, B.W.; Berg, A.A.v.D.; van Buchem, M.A. Effectiveness of percutaneous laser disc decompression versus conventional open discectomy in the treatment of lumbar disc herniation; design of a prospective randomized controlled trial. BMC Musculoskelet. Disord. 2009, 10, 49. [Google Scholar] [CrossRef] [PubMed]
- Gazzeri, R.; Tribuzi, S.; Galarza, M.; Leoni, M.L.G.; Occhigrossi, F. Ultrasound-guided Percutaneous Laser Disc Decompression (PLDD) with Fluoroscopic Validation for the Treatment of Cervical Disc Herniation: Technical Note. Pain Med. 2023, 24, 625–632. [Google Scholar] [CrossRef] [PubMed]
- Menchetti, P.P.M.; Canero, G.; Bini, W. Percutaneous laser discectomy: Experience and long term follow-up. Acta Neurochir. Suppl. 2011, 108, 117–121. [Google Scholar]
- Lee, S.H.; Kang, H.S. Percutaneous endoscopic laser annuloplasty for discogenic low back pain. World Neurosurg. 2010, 73, 198–206. [Google Scholar] [CrossRef]
- McMillan, M.R.; Patterson, P.A.; Parker, V. Percutaneous laser disc decompression for the treatment of discogenic lumbar pain and sciatica: A preliminary report with 3-month follow-up in a general pain clinic population. Photomed. Laser Surg. 2004, 22, 434–438. [Google Scholar] [CrossRef]
- Schenk, B.; Brouwer, P.A.; Peul, W.C.; van Buchem, M.A. Percutaneous laser disk decompression: A review of the literature. AJNR Am. J. Neuroradiol. 2006, 1, 232–235. [Google Scholar]
- Plapler, H.; Mancini, M.W.; Sella, V.R.; Bomfim, F.R. Evaluation of different laser wavelengths on ablation lesion and residual thermal injury in intervertebral discs of the lumbar spine. Lasers Med. Sci. 2016, 31, 421–428. [Google Scholar] [CrossRef] [PubMed]
- Cselik, Z.; Aradi, M.; von Jako, R.A.; Lelovics, Z.; Juhász, I.; Egyházi, Z.; Bogner, P.; Repa, I.; Schwarcz, A. Impact of infrared laser light-induced ablation at different wavelengths on bovine intervertebral disc ex vivo: Evaluation with magnetic resonance imaging and histology. Lasers Surg. Med. 2012, 44, 406–412. [Google Scholar] [CrossRef]
- Alò, K.M.; Wright, R.E.; Sutcliffe, J.; Brandt, S.A. Percutaneous lumbar discectomy: Clinical response in an initial cohort of fifty consecutive patients with chronic radicular pain. Pain Pract. 2004, 4, 19–29. [Google Scholar] [CrossRef] [PubMed]
- Gazzeri, R.; Tribuzi, S.; Galarza, M.; Occhigrossi, F. Percutaneous Laser Disc Decompression (PLDD) for the Treatment of Contained Lumbar Disc Herniation. Surg. Technol. Int. 2022, 41, sti41/1639. [Google Scholar] [CrossRef]
- Lipetz, J.S. Pathophysiology of inflammatory, degenerative, and compressive radiculopathies. Phys. Med. Rehabil. Clin. N. Am. 2002, 13, 439–449. [Google Scholar] [CrossRef]
- Olmarker, K.; Rydevik, B.; Hansson, T.; Holm, S. Compression-induced changes of the nutritional supply to the porcine cauda equina. J. Spinal Disord. 1990, 3, 25–29. [Google Scholar] [CrossRef]
- Lin, J.H.; Chiang, Y.H.; Chen, C.C. Lumbar radiculopathy and its neurobiological basis. World J. Anesthesiol. 2014, 3, 162–173. [Google Scholar] [CrossRef]
- Burns, T.M. Mechanisms of Acute and Chronic Compression Neuropathy. Peripheral Neuropathy, 4th ed.; Dyck, P.J., Thomas, P.K., Eds.; Elsevier: Amsterdam, The Netherlands, 2005; pp. 1391–1402. [Google Scholar]
- Hoyland, J.A.; Freemont, A.J.; Jayson, M.I. Intervertebral foramen venous obstruction. A cause of periradicular fibrosis? Spine (Phila Pa 1976) 1989, 14, 558–568. [Google Scholar] [CrossRef] [PubMed]
- Senoglu, M.; Nacitarhan, V.; Kurutas, E.B.; Senoglu, N.; Altun, I.; Atli, Y.; Ozbag, D. Intraperitoneal alpha-lipoic acid to prevent neural damage after crush injury to the rat sciatic nerve. J. Brachial Plex. Peripher. Nerve Inj. 2009, 4, e109–e114. [Google Scholar] [CrossRef]
- Tomassoni, D.; Amenta, F.; Mannelli, L.D.C.; Ghelardini, C.; Nwankwo, I.E.; Pacini, A.; Tayebati, S.K. Neuroprotective activity of thioctic acid in central nervous system lesions consequent to peripheral nerve injury. BioMed Res. Int. 2013, 2013, 985093. [Google Scholar] [CrossRef] [PubMed]
- Boyaci, M.G.; Eser, O.; Kocogullari, C.U.; Karavelioglu, E.; Tokyol, C.; Can, Y. Neuroprotective effect of alpha-lipoic acid and methylprednisolone on the spinal cord ischemia/reperfusion injury in rabbits. Br. J. Neurosurg. 2015, 29, 46–51. [Google Scholar] [CrossRef] [PubMed]
- Sola, S.; Mir, M.Q.; Cheema, F.A.; Khan-Merchant, N.; Menon, R.G.; Parthasarathy, S.; Khan, B.V. Irbesartan and lipoic acid improve endothelial function and reduce markers of inflammation in the metabolic syndrome: Results of the Irbesartan and Lipoic Acid in Endothelial Dysfunction (ISLAND) study. Circulation 2005, 111, 343–348. [Google Scholar] [CrossRef]
- Ziegler, D.; Ametov, A.; Barinov, A.; Dyck, P.J.; Gurieva, I.; Low, P.A.; Munzel, U.; Yakhno, N.; Raz, I.; Novosadova, M.; et al. Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: The SYDNEY 2 trial. Diabetes Care 2006, 29, 2365–2370. [Google Scholar] [CrossRef]
- Bakare, A.O.; Owoyele, B.V. Bromelain reduced pro-inflammatory mediators as a common pathway that mediate antinociceptive and anti-anxiety effects in sciatic nerve ligated Wistar rats. Sci. Rep. 2021, 11, 289. [Google Scholar] [CrossRef]
- Yalcin, I.; Barthas, F.; Barrot, M. Emotional consequences of neuropathic pain: Insight from preclinical studies. Neurosci. Biobehav. Rev. 2014, 47, 154–164. [Google Scholar] [CrossRef] [PubMed]
- Li, Y.; Yao, J.; Han, C.; Yang, J.; Chaudhry, M.T.; Wang, S.; Liu, H.; Yin, Y. Quercetin, Inflammation and Immunity. Nutrients 2016, 8, 167. [Google Scholar] [CrossRef]
- Andres, S.; Pevny, S.; Ziegenhagen, R.; Bakhiya, N.; Schäfer, B.; Hirsch-Ernst, K.I.; Lampen, A. Safety Aspects of the Use of Quercetin as a Dietary Supplement. Mol. Nutr. Food Res. 2018, 62, 1700447. [Google Scholar] [CrossRef]
- Alizadeh, S.R.; Ebrahimzadeh, M.A. Quercetin derivatives: Drug design, development, and biological activities, a review. Eur. J.Med. Chem. 2022, 229, 114068. [Google Scholar] [CrossRef] [PubMed]
- Wang, W.; Huang, C.Y.; Tsai, F.J.; Tsai, C.C.; Yao, C.H.; Chen, Y.S. Growth-promoting effects of quercetin on peripheral nerves in rats. Int. J. Artif. Organs 2011, 34, 1095–1105. [Google Scholar] [CrossRef]
- Barreca, D.; Bellocco, E.; D’Onofrio, G.; Nabavi, S.F.; Daglia, M.; Rastrelli, L.; Nabavi, S.M. Neuroprotective Effects of Quercetin: From Chemistry to Medicine. CNS Neurol. Disord. Drug Targets 2016, 15, 964–975. [Google Scholar] [CrossRef]
- Shen, P.; Lin, W.; Deng, X.; Ba, X.; Han, L.; Chen, Z.; Qin, K.; Huang, Y.; Tu, S. Potential Implications of Quercetin in Autoimmune Diseases. Front. Immunol. 2021, 12, 689044. [Google Scholar] [CrossRef]
- Türedi, S.; Yuluğ, E.; Alver, A.; Bodur, A.; İnce, İ. A morphological and biochemical evaluation of the effects of quercetin on experimental sciatic nerve damage in rats. Exp. Med. 2018, 15, 3215–3224. [Google Scholar]
- Manfridi, A.; Forloni, G.L.; Arrigoni-Martelli, E.; Mancia, M. Culture of dorsal root ganglion neurons from aged rats: Effects of acetyl-L carnitine and NGF. Int. J. Dev. Neurosci. 1992, 10, 321–329. [Google Scholar] [CrossRef] [PubMed]
- Hart, A.M.; Wiberg, M.; Terenghi, G. Pharmacological enhancement of peripheral nerve regeneration in the rat by systemic acetyl-L carnitine treatment. Neurosci. Lett. 2002, 334, 181–185. [Google Scholar] [CrossRef]
- Calderon-Ospina, C.A.; Nava-Mesa, M.O. B vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin. CNS Neurosci. Ther. 2020, 26, 5–13. [Google Scholar] [CrossRef]
- Gibson, G.E.; Zhang, H. Interactions of oxidative stress with thiamine homeostasis promote neurodegeneration. Neurochem. Int. 2002, 40, 493–504. [Google Scholar] [CrossRef]
- Wang, X.D.; Kashii, S.; Zhao, L.; Tonchev, A.B.; Katsuki, H.; Akaike, A.; Honda, Y.; Yamashita, J.; Yamashima, T. Vitamin B6 protects primate retinal neurons from ischemic injury. Brain Res. 2002, 940, 36–43. [Google Scholar] [CrossRef] [PubMed]
- Tamaddonfard, E.; Farshid, A.A.; Samadi, F.; Eghdami, K. Effect of vitamin B12 on functional recovery and histopathologic changes of tibial nerve-crushed rats. Drug Res. 2014, 64, 470–475. [Google Scholar] [CrossRef]
- Wang, D.; Zhang, P.; Li, Z.; Liu, Y. Effects of mecobalamin on Bax and Bcl-2 in neurons after peripheral nerve injury. Chin. J. Ind. Hyg. Occup. Dis. 2015, 33, 841–843. [Google Scholar]
PLDD (Group A) | PLDD + Dietary Integrator (Group B) | Total | |
---|---|---|---|
N° of cases | 26 | 26 | 52 |
Gender (F/M) | 12/14 | 11/15 | 23/29 |
Age | 62.3 y.o. | 64.1 y.o. | 63.2 y.o. |
BMI (kg/m2) | 21.8 | 21.9 | 21.9 |
Smoker | 7 | 8 | 15 |
Level Treated | L4-L5: 13 L5-S1: 8 L3-L4: 3 L2-L3: 1 L4-L5-S1: 1 | L4-L5: 15 L5-S1: 7 L3-L4: 2 L4-L5-S1: 1 L3-L4-L5: 1 | L4-L5: 28 L5-S1: 15 L3-L4: 5 L4-L5-S1: 2 L3-L4-L5: 1 |
Side | Right: 10 Left: 11 Bilateral: 5 | Right: 11 Left: 10 Bilateral: 5 | Right: 21 Left: 21 Bilateral: 10 |
Duration of leg pain (mths) | 7.1 | 7.9 | 7.5 |
Analgesic Use | R: 15 S: 9 N: 2 | R: 13 S: 12 N: 1 | R: 28 S: 21 N: 3 |
Follow Up (mths) | 15 | 13.9 | 14.4 |
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Gazzeri, R.; Leoni, M.L.G.; Occhigrossi, F. Efficacy of Percutaneous Laser Disc Decompression (PLDD) Combined with an Oral Food Supplement for Lumbar Disc Herniation. J. Clin. Med. 2024, 13, 5049. https://doi.org/10.3390/jcm13175049
Gazzeri R, Leoni MLG, Occhigrossi F. Efficacy of Percutaneous Laser Disc Decompression (PLDD) Combined with an Oral Food Supplement for Lumbar Disc Herniation. Journal of Clinical Medicine. 2024; 13(17):5049. https://doi.org/10.3390/jcm13175049
Chicago/Turabian StyleGazzeri, Roberto, Matteo Luigi Giuseppe Leoni, and Felice Occhigrossi. 2024. "Efficacy of Percutaneous Laser Disc Decompression (PLDD) Combined with an Oral Food Supplement for Lumbar Disc Herniation" Journal of Clinical Medicine 13, no. 17: 5049. https://doi.org/10.3390/jcm13175049