Association between Subclinical Hypothyroidism and Adverse Pregnancy Outcomes in Assisted Reproduction Technology Singleton Pregnancies: A Retrospective Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Participants
2.2. Data Collection and Definition
2.3. Statistical Analyses
3. Results
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Group A (n = 581) | Group B (n = 34) | Group C (n = 35) | p-Value | |
---|---|---|---|---|
Maternal age (years) * | 36.5 (±4.3) | 36.6 (±4.7) | 36.5 (±3.8) | 0.988 |
Pre-pregnant BMI (kg/m2) * | 21.5 (±3.4) | 22.0 (±2.6) | 21.8 (±2.8) | 0.634 |
History of abortion | 218/581 (37.5%) | 11/34 (32.4%) | 8/35 (22.9%) | 0.194 |
Preterm birth at <37 weeks | 106/581 (18.2%) | 9/34 (26.5%) | 2/35 (5.7%) | 0.059 |
Preterm birth at <34 weeks | 36/581 (6.2%) | 5/34 (14.7%) | 0/35 (0%) | 0.046 |
Preterm birth at <32 weeks | 32/581 (5.5%) | 1/34 (2.9%) | 0/35 (0%) | 0.411 |
Preterm birth at <28 weeks | 16/581 (2.8%) | 0/34 (0%) | 0/35 (0%) | 1 |
Preeclampsia | 56/581 (9.6%) | 3/34 (8.8%) | 4/35 (11.4%) | 0.945 |
Fetal growth restriction | 23/581 (4.0%) | 1/34 (2.9%) | 0/35 (0%) | 0.768 |
Cesarean delivery | 272/581 (46.8%) | 15/34 (44.1%) | 19/34 (54.3%) | 0.641 |
Blood loss at delivery (mL) * | 812 (±676) | 970 (±716) | 788 (±406) | 0.393 |
Manual placental removal | 53/581 (9.1%) | 3/34 (8.8%) | 5/35 (14.3%) | 0.591 |
Transfusion | 33/581 (5.7%) | 1/34 (2.9%) | 0/35 (0%) | 0.374 |
Neonatal birth weight (g) * | 2901 (±1339) | 2819 (±640) | 3064 (±475) | 0.705 |
TSH value (mU/L) * | 1.36 (±0.57) | 4.02 (±2.47) | 3.55 (±1.07) | <0.001 |
Adjusted OR | 95% CI | p-Value | |
---|---|---|---|
Maternal age | 1.00 | 0.956–1.05 | 0.880 |
Pre-pregnant BMI | 1.00 | 0.939–1.07 | 0.991 |
Nulliparous | 0.95 | 0.602–1.50 | 0.822 |
History of abortion | 0.97 | 0.621–1.52 | 0.899 |
Preeclampsia | 4.98 | 2.81–8.81 | <0.001 |
Fetal growth restriction | 3.31 | 1.31–8.34 | 0.011 |
Levothyroxine therapy | 1.36 | 0.378–1.36 | 0.230 |
TSH value | 1.05 | 0.485–2.29 | 0.895 |
Adjusted OR | 95% CI | p-Value | |
---|---|---|---|
Maternal age | 1.00 | 0.926–1.07 | 0.915 |
Pre-pregnant BMI | 1.03 | 0.942–1.13 | 0.506 |
Nulliparous | 1.20 | 0.567–2.53 | 0.638 |
History of abortion | 1.20 | 0.606–2.40 | 0.595 |
Preeclampsia | 3.65 | 1.65–8.09 | 0.001 |
Fetal growth restriction | 2.92 | 0.877–9.74 | 0.081 |
Levothyroxine therapy | 0.117 | 0.015–0.948 | 0.044 |
TSH value | 2.18 | 0.750–6.36 | 0.152 |
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Narita, Y.; Tsuda, H.; Tsugeno, E.; Nakamura, Y.; Suzuki, M.; Ito, Y.; Tezuka, A.; Ando, T. Association between Subclinical Hypothyroidism and Adverse Pregnancy Outcomes in Assisted Reproduction Technology Singleton Pregnancies: A Retrospective Study. J. Clin. Med. 2024, 13, 5137. https://doi.org/10.3390/jcm13175137
Narita Y, Tsuda H, Tsugeno E, Nakamura Y, Suzuki M, Ito Y, Tezuka A, Ando T. Association between Subclinical Hypothyroidism and Adverse Pregnancy Outcomes in Assisted Reproduction Technology Singleton Pregnancies: A Retrospective Study. Journal of Clinical Medicine. 2024; 13(17):5137. https://doi.org/10.3390/jcm13175137
Chicago/Turabian StyleNarita, Yuichiro, Hiroyuki Tsuda, Eri Tsugeno, Yumi Nakamura, Miho Suzuki, Yumiko Ito, Atsuko Tezuka, and Tomoko Ando. 2024. "Association between Subclinical Hypothyroidism and Adverse Pregnancy Outcomes in Assisted Reproduction Technology Singleton Pregnancies: A Retrospective Study" Journal of Clinical Medicine 13, no. 17: 5137. https://doi.org/10.3390/jcm13175137