Next Article in Journal
From Data Integration to Precision Medicine: A Value-Based Healthcare Approach for Sarcoma Care
Previous Article in Journal
Older Age as a Predictor of Ongoing Active Changes in Follow-Up Cardiac Magnetic Resonance in Children with Acute Myocarditis
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
JCM
Volume 13
Issue 21
10.3390/jcm13216499
jcm-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Changing Epidemiology and Outcomes of Hemolytic Uremic Syndrome in Children: A Prospective National Cohort Study from the Polish Pediatric HUS Registry and the Polish Registry of Renal Replacement Therapy in Children

by
Ilona Zagożdżon
1,*,
Maria Szczepańska
2,
Beata Leszczyńska
3,
Wioleta Jarmużek
4,
Monika Miklaszewska
5,
Marcin Tkaczyk
6,7,
Anna Medyńska
8,
Anna Wieczorkiewicz-Płaza
9,
Jacek Zachwieja
10,
Piotr Protas
11,
Paulina Rosińska
12,
Urszula Jacher
13,
Elżbieta Trembecka-Dubel
2,
Danuta Zwolińska
8 and
Aleksandra Żurowska
1
1
Department of Pediatrics, Nephrology and Hypertension, Medical University of Gdansk, 80-210 Gdansk, Poland
2
Department of Pediatrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, 40-055 Katowice, Poland
3
Department of Pediatrics and Nephrology, Medical University of Warsaw, 02-091 Warsaw, Poland
4
Department of Nephrology, Kidney Transplantation and Arterial Hypertension, The Children’s Memorial Health Institute, 04-730 Warsaw, Poland
5
Department of Pediatric Nephrology and Hypertension, Jagiellonian Univeristy Medical College, 31-007 Kraków, Poland
6
Department of Pediatrics, Immunology and Nephrology, Polish Mother’s Memorial Hospital Research Institute, 93-338 Lodz, Poland
7
Department of Pediatrics, Nephrology and Immunology, Medical University of Lodz, 93-338 Lodz, Poland
8
Department and Clinic of Pediatric Nephrology, Medical University of Wroclaw, 02-091 Wroclaw, Poland
9
2nd Department of Pediatrics, Department of Pediatric Nephrology, Medical University of Lublin, 20-059 Lublin, Poland
10
Department of Pediatric Nephrology and Hypertension, Poznań University of Medical Sciences, 61-701 Poznan, Poland
11
Department of Pediatrics and Nephrology, Medical University of Bialystok, 15-089 Bialystok, Poland
12
Department of Nephrology, Specialist Children Hospital, 87-100 Torun, Poland
13
Department of Pediatrics, Nephrology and Dialysis, Pomeranian Medical University, 70-204 Szczecin, Poland
 
add Show full affiliation list
 
remove Hide full affiliation list
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2024, 13(21), 6499; https://doi.org/10.3390/jcm13216499
Submission received: 23 September 2024 / Revised: 17 October 2024 / Accepted: 28 October 2024 / Published: 30 October 2024
(This article belongs to the Section Clinical Pediatrics)
Browse Figures
Versions Notes

Abstract

Background/Objectives: Hemolytic uremic syndrome (HUS) is a known cause of acute kidney injury in children, but there are few recent reports on its epidemiology and outcome. We aimed to investigate trends in the incidence and the long-term outcomes of both Shiga toxin-producing Escherichia coli -HUS (STEC-HUS) and atypical HUS (aHUS) in Poland over the last 12 years (2012—2023), based on the Polish Pediatric HUS and Pediatric Renal Replacement Therapy (RRT) Registries. Methods: A total of 436 patients (301 with STEC-HUS and 135 with aHUS) were included. Results: The incidence of STEC-HUS increased during the observation period, with a mean of 3.9 cases per million age-related population (marp). The incidence of aHUS was relatively constant with a mean of 1.8/marp. The majority of patients fully recovered, although kidney sequelae were observed at 5-year follow-ups in 31% of children with STEC-HUS, 57% of aHUS subjects in the pre-eculizumab era, and 37% of aHUS subjects who had received eculizumab. The overall mortality rate was 2% for STEC-HUS and 3.7% for aHUS, with no deaths reported in children on eculizumab and mortality mainly attributed to neurological damage. A decreasing incidence of chronic kidney disease stage 5 (CKD5) due to HUS was observed. Conclusions: Despite an unchanging incidence of aHUS and an increasing incidence of STEC-HUS, the kidney outcomes of both diseases have improved significantly over the last 12 years. Mortality from HUS has dropped due to improved symptomatic treatment and the introduction of anti-C5 therapy. The development of CKD5 in childhood as a consequence of HUS has become exceptional.
Keywords: hemolytic uremic syndrome; children; incidence; mortality; chronic kidney disease hemolytic uremic syndrome; children; incidence; mortality; chronic kidney disease
Graphical Abstract

Share and Cite

MDPI and ACS Style

Zagożdżon, I.; Szczepańska, M.; Leszczyńska, B.; Jarmużek, W.; Miklaszewska, M.; Tkaczyk, M.; Medyńska, A.; Wieczorkiewicz-Płaza, A.; Zachwieja, J.; Protas, P.; et al. Changing Epidemiology and Outcomes of Hemolytic Uremic Syndrome in Children: A Prospective National Cohort Study from the Polish Pediatric HUS Registry and the Polish Registry of Renal Replacement Therapy in Children. J. Clin. Med. 2024, 13, 6499. https://doi.org/10.3390/jcm13216499

AMA Style

Zagożdżon I, Szczepańska M, Leszczyńska B, Jarmużek W, Miklaszewska M, Tkaczyk M, Medyńska A, Wieczorkiewicz-Płaza A, Zachwieja J, Protas P, et al. Changing Epidemiology and Outcomes of Hemolytic Uremic Syndrome in Children: A Prospective National Cohort Study from the Polish Pediatric HUS Registry and the Polish Registry of Renal Replacement Therapy in Children. Journal of Clinical Medicine. 2024; 13(21):6499. https://doi.org/10.3390/jcm13216499

Chicago/Turabian Style

Zagożdżon, Ilona, Maria Szczepańska, Beata Leszczyńska, Wioleta Jarmużek, Monika Miklaszewska, Marcin Tkaczyk, Anna Medyńska, Anna Wieczorkiewicz-Płaza, Jacek Zachwieja, Piotr Protas, and et al. 2024. "Changing Epidemiology and Outcomes of Hemolytic Uremic Syndrome in Children: A Prospective National Cohort Study from the Polish Pediatric HUS Registry and the Polish Registry of Renal Replacement Therapy in Children" Journal of Clinical Medicine 13, no. 21: 6499. https://doi.org/10.3390/jcm13216499

APA Style

Zagożdżon, I., Szczepańska, M., Leszczyńska, B., Jarmużek, W., Miklaszewska, M., Tkaczyk, M., Medyńska, A., Wieczorkiewicz-Płaza, A., Zachwieja, J., Protas, P., Rosińska, P., Jacher, U., Trembecka-Dubel, E., Zwolińska, D., & Żurowska, A. (2024). Changing Epidemiology and Outcomes of Hemolytic Uremic Syndrome in Children: A Prospective National Cohort Study from the Polish Pediatric HUS Registry and the Polish Registry of Renal Replacement Therapy in Children. Journal of Clinical Medicine, 13(21), 6499. https://doi.org/10.3390/jcm13216499

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop