Systematic Review of Variations in Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for Peritoneal Metastasis from Colorectal Cancer
Abstract
:1. Introduction
2. Methods
2.1. Database Search and Source of Information
2.2. Quality Assessment
2.3. Data Extraction
2.4. Data Synthesis
2.5. Compliance with Applicable Guidelines
3. Results
3.1. Literature Search and Evaluation
3.2. Heterogeneity in HIPEC Conduct
3.3. Drugs Used for HIPEC in Peritoneal Metastasis from Colorectal Cancer
3.4. HIPEC Conduct with Mitomycin C (MMC)
3.5. HIPEC Conduct with Oxaliplatin (L-OHP)
3.6. HIPEC Protocols Describing Combined Drug Use
3.7. Uncommon HIPEC Drugs
3.8. Differences in Exposure Times to Cytotoxic Drugs
3.9. Differences in Benchmarking Applied Drug Dosages
3.10. Carrier Solutions and Diluent Quantities
3.11. HIPEC Protocols Describing the Use of an Open and Closed Technique
3.12. HIPEC Protocols Entailing Simultaneous Intravenous and Intraperitoneal (Bidirectional) Drug Administration and Early Postoperative Intraperitoneal Chemotherapy (EPIC)
3.13. Hyperthermia
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
5-FU | 5-fluorouracil |
°C | degree Celsius |
CDDP | cisplatin; (cis-diamminedichloridoplatinum(II)) |
CRC | colorectal carcinoma |
CRS | cytoreductive surgery |
CS | carrier solution |
DOX | doxorubicin |
EPIC | early postoperative intraperitoneal chemotherapy |
ETO | etoposide |
HIPEC | hyperthermic intraperitoneal chemotherapy |
HCPT | hydroxycamptothecin |
IRI | irinotecan |
L | liter |
L-OHP | oxaliplatin; (trans-L-(–)-Diaminocyclohexanoxalatoplatin) |
i.v. | intravenous |
L-PAM | melphalan; (L-Phenylalanine Mustard) |
m2 | square meter; refers to body surface area |
MMC | mitomycin C |
PM | peritoneal metastasis |
PRISMA | Preferred Reporting Items for Systematic Reviews and Meta-Analyses |
RCT | randomized controlled trial |
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Yurttas, C.; Hoffmann, G.; Tolios, A.; Haen, S.P.; Schwab, M.; Königsrainer, I.; Königsrainer, A.; Beckert, S.; Löffler, M.W. Systematic Review of Variations in Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for Peritoneal Metastasis from Colorectal Cancer. J. Clin. Med. 2018, 7, 567. https://doi.org/10.3390/jcm7120567
Yurttas C, Hoffmann G, Tolios A, Haen SP, Schwab M, Königsrainer I, Königsrainer A, Beckert S, Löffler MW. Systematic Review of Variations in Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for Peritoneal Metastasis from Colorectal Cancer. Journal of Clinical Medicine. 2018; 7(12):567. https://doi.org/10.3390/jcm7120567
Chicago/Turabian StyleYurttas, Can, Giulia Hoffmann, Alexander Tolios, Sebastian P. Haen, Matthias Schwab, Ingmar Königsrainer, Alfred Königsrainer, Stefan Beckert, and Markus W. Löffler. 2018. "Systematic Review of Variations in Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for Peritoneal Metastasis from Colorectal Cancer" Journal of Clinical Medicine 7, no. 12: 567. https://doi.org/10.3390/jcm7120567