High Concentration of Serum Aspartate Aminotransferase in Older Underweight People: Results of the Kanagawa Investigation of the Total Check-Up Data from the National Database-2 (KITCHEN-2)
Abstract
:1. Introduction
2. Methods
2.1. Study Design
2.2. Subjects
2.3. Measurements of Clinical Parameters
2.4. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Acknowledgments
Conflicts of Interest
References
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Age group (years old) | 40–49 | 50–59 | 60–74 |
---|---|---|---|
n (%) | 288,134 (32.3) | 246,700 (27.6) | 357,858 (40.1) |
Male, n (%) | 173,096 (60.1) | 140,837 (57.1) | 161,567 (45.1) |
Age (years) | 44.3 ± 2.5 | 54.7 ± 2.5 | 66.8 ± 4 |
BMI (kg/m2) | 22.9 ± 3.5 | 23.0 ± 3.3 | 22.8 ± 3.1 |
Waist circumference (cm) * | 81.2 ± 9.6 | 82.5 ± 9.2 | 82.7 ± 8.9 |
Underweight BMI <18.5 (kg/m2), n (%) | 21,526 (7.5) | 15,654 (6.3) | 23,914 (6.7) |
Very severe underweight BMI <15 (kg/m2), n (%) | 185 (0.06) | 198 (0.08) | 527 (0.15) |
AST (U/L) | 21.9 ± 8.9 | 23.2 ± 9 | 24.2 ± 9.1 |
ALT (U/L) | 23.8 ± 17.2 | 23.4 ± 14.5 | 21.5 ± 12 |
AST/ALT ratio | 1.06 (0.82–1.33) | 1.08 (0.88–1.33) | 1.19 (1.00–1.43) |
AST ≥30 U/L, n (%) | 33,573 (11.7) | 33,153 (13.4) | 53,993 (15.1) |
ALT ≥30 U/L, n (%) | 63,900 (22.2) | 48,620 (19.7) | 51,526 (14.4) |
γ-Glutamyl transferase (U/L) | 38.1 ± 37 | 41.5 ± 38.7 | 34.5 ± 31.5 |
Triglyceride (mg/dL) | 88 (60–137) | 97 (68–144) | 99 (73–139) |
High-density lipoprotein cholesterol (mg/dL) | 63.5 ± 16.7 | 64.9 ± 17.5 | 64.3 ± 16.8 |
Pharmacotherapy for | |||
Hypertension, n (%) | 13,203 (4.6) | 37,634 (15.3) | 112,871 (31.5) |
Diabetes, n (%) | 3479 (1.2) | 8354 (3.4) | 19,588 (5.5) |
Dyslipidemia, n (%) | 7376 (2.6) | 19,279 (7.8) | 66,228 (18.5) |
Medical history Cardiovascular disease, n (%) | 3520 (1.2) | 7049 (2.9) | 25,162 (7) |
Medical history Cerebrovascular disease, n (%) ** | 1351 (0.5) | 3087 (1.3) | 13,456 (3.8) |
Current smokers, n (%) | 91,056 (31.6) | 70,808 (28.7) | 51,051 (14.3) |
Alcohol drinking | |||
Every day, n (%) | 82,992 (28.8) | 79,796 (32.3) | 92,531 (25.9) |
Exercise (≥30 min per session) at least twice/week, n (%) | 59,939 (20.8) | 63,928 (25.9) | 157,507 (44) |
Physical activity (≥1 hour/day), n (%) | 106,312 (36.9) | 95,933 (38.9) | 193,975 (54.2) |
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Shibata, M.; Nakajima, K.; Higuchi, R.; Iwane, T.; Sugiyama, M.; Nakamura, T. High Concentration of Serum Aspartate Aminotransferase in Older Underweight People: Results of the Kanagawa Investigation of the Total Check-Up Data from the National Database-2 (KITCHEN-2). J. Clin. Med. 2019, 8, 1282. https://doi.org/10.3390/jcm8091282
Shibata M, Nakajima K, Higuchi R, Iwane T, Sugiyama M, Nakamura T. High Concentration of Serum Aspartate Aminotransferase in Older Underweight People: Results of the Kanagawa Investigation of the Total Check-Up Data from the National Database-2 (KITCHEN-2). Journal of Clinical Medicine. 2019; 8(9):1282. https://doi.org/10.3390/jcm8091282
Chicago/Turabian StyleShibata, Michi, Kei Nakajima, Ryoko Higuchi, Taizo Iwane, Michiko Sugiyama, and Teiji Nakamura. 2019. "High Concentration of Serum Aspartate Aminotransferase in Older Underweight People: Results of the Kanagawa Investigation of the Total Check-Up Data from the National Database-2 (KITCHEN-2)" Journal of Clinical Medicine 8, no. 9: 1282. https://doi.org/10.3390/jcm8091282