Interval Cancer Rate and Diagnostic Performance of Fecal Immunochemical Test According to Family History of Colorectal Cancer
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Population
2.2. Fecal Immunochemical Test
2.3. Definition of CRC Status and Variables of Interest
2.4. Statistical Analysis
3. Results
3.1. Participants and Baseline Characteristics
3.2. FIT Positivity Rate, CDR, and ICR
3.3. Diagnostic Performance of FIT
4. Discussion
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
References
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Total N = 5,643,438 | Family History of CRC n = 224,178 | No Family History of CRC n = 5,419,260 | p-value | |
---|---|---|---|---|
Sex | ||||
Male | 2,465,771 (43.7) | 95,298 (42.5) | 2,370,473 (43.7) | <0.001 |
Female | 3,177,667 (56.3) | 128,880 (57.5) | 3,048,787 (56.3) | |
Age (years) | 60.6 ± 8.2 | 59.6 ± 7.8 | 60.7 ± 8.2 | <0.001 |
50–59 | 2,796,297 (49.5) | 123,579 (55.1) | 2,672,718 (49.3) | <0.001 |
60–69 | 1,878,505 (33.3) | 70,750 (31.6) | 1,807,755 (33.4) | |
70–79 | 857,530 (15.2) | 26,805 (12.0) | 830,725 (15.3) | |
≥80 | 111,106 (2.0) | 3,044 (1.4) | 108,062 (2.0) | |
History of colonoscopy within past 5 years | ||||
No | 4,773,868 (84.6) | 179,259 (80.0) | 4,594,609 (84.8) | <0.001 |
Yes | 869,570 (15.4) | 44,919 (20.0) | 824,651 (15.2) | |
History of polypectomy | 186,437 (3.3) | 9,887 (4.4) | 176,550 (3.3) | <0.001 |
FIT positive | 334,195 (5.9) | 14,385 (6.4) | 319,810 (5.9) | <0.001 |
CRC detection * | 16,363 (0.29) | 845 (0.38) | 15,518 (0.29) | <0.001 |
Interval cancer ** | 5,865/5,309,243 (0.11) | 301/209,793 (0.14) | 5,564/5,099,450 (0.11) | <0.001 |
FIT Positive Rate | Cancer Detection Rate | Interval Cancer Rate | |||||||
---|---|---|---|---|---|---|---|---|---|
% (95% CI) | aRR (95% CI) | p-value | Per 1000 * (95% CI) | aRR (95% CI) | p-value | Per 1000 ** (95% CI) | aRR (95% CI) | p-value | |
All participants | |||||||||
FHx of CRC | |||||||||
No | 5.9 (5.9–5.9) | 1.00 (ref) | 2.9 (2.8–2.9) | 1.00 (ref) | 1.1 (1.1–1.1) | 1.00 (ref) | |||
Yes | 6.4 (6.3–6.5) | 1.11 (1.09–1.13) | <0.001 | 3.8 (3.5–4.0) | 1.43 (1.33–1.53) | <0.001 | 1.4 (1.3–1.6) | 1.43 (1.27–1.60) | <0.001 |
Without previous colonoscopy ≤5 years | |||||||||
FHx of CRC | |||||||||
No | 6.0 (5.9–6.0) | 1.00 (ref) | 3.2 (3.2–3.3) | 1.00 (ref) | 1.2 (1.2–1.2) | 1.00 (ref) | |||
Yes | 6.6 (6.5–6.7) | 1.12 (1.10–1.14) | <0.001 | 4.4 (4.1–4.7) | 1.48 (1.38–1.59) | <0.001 | 1.6 (1.4–1.8) | 1.46 (1.29–1.65) | <0.001 |
With previous colonoscopy ≤5 years | |||||||||
FHx of CRC | |||||||||
No | 5.5 (5.5–5.6) | 1.00 (ref) | 0.9 (0.9–1.0) | 1.00 (ref) | 0.6 (0.5–0.6) | 1.00 (ref) | |||
Yes | 5.8 (5.6–6.0) | 1.07 (1.03–1.11) | <0.001 | 1.2 (0.9–1.6) | 1.50 (1.15–1.97) | 0.003 | 0.8 (0.5–1.0) | 1.51 (1.06–2.15) | 0.023 |
Sensitivity | Specificity | PPV | NPV | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
% (95% CI) | aRR (95% CI) | p-value | % (95% CI) | aRR (95% CI) | p-value | % (95% CI) | aRR | p-value | % (95% CI) | aRR | p-value | |
Total | ||||||||||||
FHx of CRC | ||||||||||||
No | 64.1 (63.4–64.9) | 1.00 (ref) | 94.3 (94.2–94.3) | 1.00 (ref) | 3.1 (3.1–3.2) | 1.00 (ref) | 99.9 (99.9–99.9) | 1.00 (ref) | ||||
Yes | 64.4 (61.2–67.6) | 1.01 (0.92–1.10) | 0.903 | 93.8 (93.7–93.9) | 0.994 (0.990–0.999) | 0.008 | 3.8 (3.5–4.1) | 1.29 (1.18–1.41) | <0.001 | 99.9 (99.8–99.9) | 1.000 (0.995–1.004) | 0.849 |
Without previous colonoscopy ≤5 years | ||||||||||||
FHx of CRC | ||||||||||||
No | 65.3 (64.6–66.1) | 1.00 (ref) | 94.2 (94.2–94.2) | 1.00 (ref) | 3.5 (3.5–3.6) | 1.00 (ref) | 99.9 (99.9–99.9) | 1.00 (ref) | ||||
Yes | 66.0 (62.7–69.3) | 1.01 (0.93–1.11) | 0.785 | 93.7 (93.6–93.8) | 0.993 (0.989–0.998) | 0.008 | 4.4 (4.1–4.8) | 1.33 (1.22–1.45) | <0.001 | 99.8 (99.8–99.9) | 1.000 (0.995–1.004) | 0.841 |
With previous colonoscopy ≤5 years | ||||||||||||
FHx of CRC | ||||||||||||
No | 41.4 (37.9–44.9) | 1.00 (ref) | 94.5 (94.4–94.5) | 1.00 (ref) | 0.7 (0.6–0.8) | 1.00 (ref) | 99.9 (99.9–99.9) | 1.00 (ref) | ||||
Yes | 41.1 (28.2–54.0) | 1.00 (0.66–1.53) | 0.990 | 94.2 (94.0–94.4) | 0.996 (0.986–1.006) | 0.435 | 0.9 (0.5–1.2) | 1.41 (0.92–2.15) | 0.114 | 99.9 (99.9–99.9) | 1.00 (0.99–1.01) | 0.958 |
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Jung, Y.S.; Lee, J.; Lee, H.A.; Moon, C.M. Interval Cancer Rate and Diagnostic Performance of Fecal Immunochemical Test According to Family History of Colorectal Cancer. J. Clin. Med. 2020, 9, 3302. https://doi.org/10.3390/jcm9103302
Jung YS, Lee J, Lee HA, Moon CM. Interval Cancer Rate and Diagnostic Performance of Fecal Immunochemical Test According to Family History of Colorectal Cancer. Journal of Clinical Medicine. 2020; 9(10):3302. https://doi.org/10.3390/jcm9103302
Chicago/Turabian StyleJung, Yoon Suk, Jinhee Lee, Hye Ah Lee, and Chang Mo Moon. 2020. "Interval Cancer Rate and Diagnostic Performance of Fecal Immunochemical Test According to Family History of Colorectal Cancer" Journal of Clinical Medicine 9, no. 10: 3302. https://doi.org/10.3390/jcm9103302