Metabolomic Profiles Predict Diabetes Remission after Bariatric Surgery
Abstract
:1. Introduction
2. Methods
2.1. Study Participants
2.2. Surgical Procedures
2.3. Management of Nutrition and Blood Glucose
2.4. Measurements of Serum AAMs
2.5. Outcome Measures
2.6. Statistical Analysis
3. Results
3.1. Patients’ Baseline Characteristics
3.2. Patients’ Characteristics at 3 and 12 Months Postoperatively
3.3. Prediction of T2D Remission after Bariatric Surgery
3.4. Postoperative Changes in L-DOPA and 3-HAA
4. Discussion
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Variables | Diabetes Status 1 Year after Bariatric Surgery | p Value | |
---|---|---|---|
Remission (n = 14) | Non-Remission (n = 10) | ||
Age, y | 41.0 ± 8.7 | 54.8 ± 8.0 | 0.004 |
Female sex, no. (%) | 12 (85.7) | 5 (50.0) | 0.058 |
Body mass index, kg/m2 | 39.6 ± 7.9 | 33.9 ± 4.5 | 0.116 |
Body weight, kg | 106.1 ± 31.2 | 89.7 ± 18.4 | 0.251 |
Waist circumference, cm | 120.5 ± 19.9 | 112.1 ± 9.7 | 0.347 |
Waist-to-hip ratio | 0.97 ± 0.05 | 1.03 ± 0.01 | 0.017 |
Duration of diabetes, y | 2.2 ± 1.4 | 8.9 ± 8.6 | 0.009 |
Use of insulin, no. (%) | 2 (14.3) | 3 (30.0) | 0.350 |
Current smoker, no. (%) | 3 (21.4) | 2 (20.0) | 0.932 |
Hypertension, no. (%) | 5 (35.7) | 5 (50.0) | 0.484 |
Dyslipidemia, no. (%) | 9 (64.2) | 6 (60.0) | 0.831 |
Surgical methods (RYGB/SG), no. (%) | 5/9 (35.7/64.3) | 5/5 (50.0/50.0) | 0.484 |
ABCD score | 6.2 ± 2.0 | 3.3 ± 2.7 | 0.015 |
DiaRem score | 4.7 ± 5.4 | 12.0 ± 5.3 | 0.013 |
IMS score | 39.3 ± 22.9 | 88.2 ± 30.6 | 0.001 |
Variables | Remission | Non-Remission | p Value for Baseline | p Value for 3 Months | p Value for 12 Months | ||||
---|---|---|---|---|---|---|---|---|---|
Baseline (n = 14) | 3 Months (n = 14) | 12 Months (n = 14) | Baseline (n = 10) | 3 Months (n = 10) | 12 Months (n = 10) | ||||
Glycated hemoglobin, % | 7.2 ± 2.0 | 5.6 ± 0.3 | 5.4 ± 0.2 | 8.9 ± 1.1 | 7.3 ± 1.1 | 7.6 ± 1.0 | 0.067 | <0.001 | <0.001 |
Fasting plasma glucose, mg/dL | 151.1 ± 65.3 | 98.3 ± 9.8 | 97.2 ± 7.8 | 146.1 ± 51.9 | 129 ± 22.9 | 131 ± 26.6 | 0.871 | <0.001 | <0.001 |
Body mass index, kg/m2 | 39.6 ± 7.9 | 32.3 ± 7.7 | 28.8 ± 6.6 | 33.9 ± 4.5 | 29.4 ± 4.5 | 28.9 ± 5.6 | 0.116 | 0.409 | 0.974 |
Body weight, kg | 106.1 ± 31.2 | 87.7 ± 29.8 | 77.0 ± 24.9 | 89.7 ± 18.4 | 77.9 ± 17.6 | 76.7 ± 20.1 | 0.251 | 0.471 | 0.977 |
% Excess weight loss | - | 62.9 ± 31.5 | 90.6 ± 38.3 | - | 59.4 ± 24.7 | 68.8 ± 32.4 | - | 0.818 | 0.240 |
% Weight loss | - | 18.2 ± 4.1 | 27.6 ± 5.2 | - | 13.4 ± 2.7 | 15.1 ± 5.8 | - | 0.019 | <0.001 |
Waist circumference, cm | 120.5 ± 19.9 | 104.6 ± 21.0 | 93.8 ± 16.5 | 112.1 ± 9.7 | 98.4 ± 12.4 | 98.1 ± 12.5 | 0.347 | 0.515 | 0.573 |
Systolic blood pressure, mmHg | 135.7 ± 9.8 | 125.1 ± 12.1 | 120.1 ± 13.1 | 136.8 ± 8.4 | 124.1 ± 11.5 | 130 ± 10.2 | 0.812 | 0.870 | 0.120 |
Diastolic blood pressure, mmHg | 84.5 ± 9.8 | 77.6 ± 10.9 | 74.5 ± 9.1 | 85.0 ± 4.9 | 73.6 ± 12.7 | 77.1 ± 11.40 | 0.908 | 0.496 | 0.585 |
High-density lipoprotein cholesterol, mg/dL | 49.5 ± 9.8 | 48.6 ± 10.7 | 60.1 ± 12.2 | 46.6 ± 8.5 | 46.1 ± 13.1 | 52.5 ± 11.2 | 0.549 | 0.671 | 0.208 |
Triglycerides, mg/dL | 204.4 ± 232.3 | 110.6 ± 38.7 | 94.5 ± 36.0 | 174.6 ± 140.6 | 149.5 ± 88.6 | 139 ± 77.5 | 0.776 | 0.193 | 0.091 |
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Ha, J.; Jang, M.; Kwon, Y.; Park, Y.S.; Park, D.J.; Lee, J.-H.; Lee, H.-J.; Ha, T.K.; Kim, Y.-J.; Han, S.-M.; et al. Metabolomic Profiles Predict Diabetes Remission after Bariatric Surgery. J. Clin. Med. 2020, 9, 3897. https://doi.org/10.3390/jcm9123897
Ha J, Jang M, Kwon Y, Park YS, Park DJ, Lee J-H, Lee H-J, Ha TK, Kim Y-J, Han S-M, et al. Metabolomic Profiles Predict Diabetes Remission after Bariatric Surgery. Journal of Clinical Medicine. 2020; 9(12):3897. https://doi.org/10.3390/jcm9123897
Chicago/Turabian StyleHa, Jane, Mi Jang, Yeongkeun Kwon, Young Suk Park, Do Joong Park, Joo-Ho Lee, Hyuk-Joon Lee, Tae Kyung Ha, Yong-Jin Kim, Sang-Moon Han, and et al. 2020. "Metabolomic Profiles Predict Diabetes Remission after Bariatric Surgery" Journal of Clinical Medicine 9, no. 12: 3897. https://doi.org/10.3390/jcm9123897