Changes in Red Blood Cell Properties and Platelet Function during Extracorporeal Membrane Oxygenation
Abstract
:1. Introduction
2. Experimental Section
2.1. Trial Design and Patients
2.2. Study Population
2.3. ECMO Management
2.4. Blood Sampling
2.5. Laser-Assisted Optical Rotational Red Cell Analyzer
2.6. Multiple Electrode Aggregometry
2.7. Statistics
3. Results
3.1. Population
3.2. Laser-Assisted Optical Rotational Red Cell Analyzer
3.2.1. Red Blood Cell Aggregation
3.2.2. Red Blood Cell Deformability
3.3. Platelet Function Analysis with Multiplate
4. Discussion
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Patients (n) | 16 |
---|---|
Age, mean | 50 ± 12 |
Gender, male | 10 (63%) |
Body mass index (kg/m2), mean | 26 ± 4 |
ECMO modus, VA (%) | 9 (56%) |
Diagnosis: | |
Pulmonary | 7 (44%) |
Cardiac | 6 (37%) |
ECPR | 3 (19%) |
APACHE IV score, mean | 101 ± 35 |
Duration of ECMO, days median (IQR) | 5.5 (2.25–14.5) |
Successful weaning of ECMO | 7 (44%) |
Hemoglobin, prior to start ECMO, mean | 6.7 ± 1.6 mmol/L |
Platelets, prior to start ECMO, mean | 223 ± 101 × 109/L |
D-dimers, on the first day of ECMO, mean | 6795 ± 12,878 μg/L |
Fibrinogen, on the first day of ECMO, mean | 4.4 ± 2.7 g/L |
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Lansink-Hartgring, A.O.; Hoffmann, R.; van den Bergh, W.; de Vries, A. Changes in Red Blood Cell Properties and Platelet Function during Extracorporeal Membrane Oxygenation. J. Clin. Med. 2020, 9, 1168. https://doi.org/10.3390/jcm9041168
Lansink-Hartgring AO, Hoffmann R, van den Bergh W, de Vries A. Changes in Red Blood Cell Properties and Platelet Function during Extracorporeal Membrane Oxygenation. Journal of Clinical Medicine. 2020; 9(4):1168. https://doi.org/10.3390/jcm9041168
Chicago/Turabian StyleLansink-Hartgring, Annemieke Oude, Roland Hoffmann, Walter van den Bergh, and Adrianus de Vries. 2020. "Changes in Red Blood Cell Properties and Platelet Function during Extracorporeal Membrane Oxygenation" Journal of Clinical Medicine 9, no. 4: 1168. https://doi.org/10.3390/jcm9041168