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Volume 13
Issue 4
10.3390/jfb13040304
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Review
Peer-Review Record

Virus-like Particles for TEM Regulation and Antitumor Therapy

J. Funct. Biomater. 2022, 13(4), 304; https://doi.org/10.3390/jfb13040304
by Zhu Yang 1,2, Yongjie Chi 1,2, Jiaxin Bao 1,3, Xin Zhao 1,3, Jing Zhang 1,2 and Lianyan Wang 1,2,*
Reviewer 1: Anonymous
Reviewer 2:
Piotr Kurcok
J. Funct. Biomater. 2022, 13(4), 304; https://doi.org/10.3390/jfb13040304
Submission received: 21 November 2022 / Revised: 4 December 2022 / Accepted: 15 December 2022 / Published: 17 December 2022
(This article belongs to the Special Issue Tumor Microenvironment Regulation and Antitumor Therapy Based on Nanoparticles)

Round 1

Reviewer 1 Report

The overall structure is well organized and the numerous examples of the works reported in literature help the reader to catch the overall concepts of virus-like-particles for TEM regulation and antitumor therapy.

So I would recommend it for publication only after these revisions:

1. There are important references missing in the introduction about using nanoparticles in cancer.

Please add them:
- Nat Mater. 2016 Oct;15(10):1128-38. doi: 10.1038/nmat4707.
- Adv Mater. 2019 Sep;31(36):e1901166.
- Biomaterials. 2017 Jul;134:202-215. doi: 10.1016/j.biomaterials.2017.04.046.
- Adv Mater. 2015 Nov 25;27(44):7117-22. doi: 10.1002/adma.201503869.
- ACS Nano. 2013 Sep 24;7(9):8089-97. doi: 10.1021/nn4033757.
- Nat Commun. 2016 Sep 19;7:12868.
- Int J Pharm. 2019 Jun 30;565:50-58.

2. The scheme with a timeline for the last 10-15 years on the development of
the first virus-like particles for cancer needs to be improved, in order to give the readers the idea of when and for which applications these particles were used. The timeline presents is too simplistic.

3. A figure/scheme representing the pros and cons of virus-like particles compared with nanomaterials strategies for example must be added to the manuscript.

4. The presented figures are interesting and relevant but the design should be improved in order to meet the journal high standards. Some of them are a bit blurry.

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

The reviewed article deals with an extremely topical issue, namely anti-cancer vaccines. In addition to the extremely popular and even implemented nanoparticles/drug carriers (e.g. micelles made of PEGylated synthetic polymers), virus-like particles create new possibilities in anti-cancer therapy. In the article, the authors discussed the essence of VLPs, i.e. their construction and the possibility of modification in order to achieve the desired target. The manuscript is well-written and covers issues related to the purpose of VLPs.

Author Response

We thank the reviewer for his positive comments on the quality of the article, and we have made minor revisions and corrections based on this.

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