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Review

Research on the Current Application Status of Magnesium Metal Stents in Human Luminal Cavities

by
Xiang Chen
1,†,
Yan Xia
2,†,
Sheng Shen
3,4,
Chunyan Wang
4,5,
Rui Zan
3,4,
Han Yu
6,
Shi Yang
6,
Xiaohong Zheng
7,
Jiankang Yang
7,
Tao Suo
3,4,
Yaqi Gu
1,7,* and
Xiaonong Zhang
6,*
1
School of Medicine, Anhui University of Science and Technology, Huainan 232000, China
2
School of Stomatology, Anhui Medical College, Hefei 230601, China
3
Department of Biliary Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China
4
Shanghai Engineering Research Center of Biliary Tract Minimal Invasive Surgery and Materials, Shanghai 200032, China
5
Department of General Surgery, Shanghai Xuhui Central Hospital, Shanghai 200031, China
6
State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
7
Department of Hepatopancreatobiliary Surgery, Huainan Xinhua Hospital Affiliated to Anhui University of Science and Technology, Huainan 232000, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
J. Funct. Biomater. 2023, 14(9), 462; https://doi.org/10.3390/jfb14090462
Submission received: 4 August 2023 / Revised: 1 September 2023 / Accepted: 6 September 2023 / Published: 8 September 2023
(This article belongs to the Special Issue Corrosion Science in Biodegradable Implants)
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Abstract

The human body comprises various tubular structures that have essential functions in different bodily systems. These structures are responsible for transporting food, liquids, waste, and other substances throughout the body. However, factors such as inflammation, tumors, stones, infections, or the accumulation of substances can lead to the narrowing or blockage of these tubular structures, which can impair the normal function of the corresponding organs or tissues. To address luminal obstructions, stenting is a commonly used treatment. However, to minimize complications associated with the long-term implantation of permanent stents, there is an increasing demand for biodegradable stents (BDS). Magnesium (Mg) metal is an exceptional choice for creating BDS due to its degradability, good mechanical properties, and biocompatibility. Currently, the Magmaris® coronary stents and UNITY-BTM biliary stent have obtained Conformité Européene (CE) certification. Moreover, there are several other types of stents undergoing research and development as well as clinical trials. In this review, we discuss the required degradation cycle and the specific properties (anti-inflammatory effect, antibacterial effect, etc.) of BDS in different lumen areas based on the biocompatibility and degradability of currently available magnesium-based scaffolds. We also offer potential insights into the future development of BDS.
Keywords: Mg; Mg-based stent; biodegradable stents; luminal cavities applications; clinical translation Mg; Mg-based stent; biodegradable stents; luminal cavities applications; clinical translation

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MDPI and ACS Style

Chen, X.; Xia, Y.; Shen, S.; Wang, C.; Zan, R.; Yu, H.; Yang, S.; Zheng, X.; Yang, J.; Suo, T.; et al. Research on the Current Application Status of Magnesium Metal Stents in Human Luminal Cavities. J. Funct. Biomater. 2023, 14, 462. https://doi.org/10.3390/jfb14090462

AMA Style

Chen X, Xia Y, Shen S, Wang C, Zan R, Yu H, Yang S, Zheng X, Yang J, Suo T, et al. Research on the Current Application Status of Magnesium Metal Stents in Human Luminal Cavities. Journal of Functional Biomaterials. 2023; 14(9):462. https://doi.org/10.3390/jfb14090462

Chicago/Turabian Style

Chen, Xiang, Yan Xia, Sheng Shen, Chunyan Wang, Rui Zan, Han Yu, Shi Yang, Xiaohong Zheng, Jiankang Yang, Tao Suo, and et al. 2023. "Research on the Current Application Status of Magnesium Metal Stents in Human Luminal Cavities" Journal of Functional Biomaterials 14, no. 9: 462. https://doi.org/10.3390/jfb14090462

APA Style

Chen, X., Xia, Y., Shen, S., Wang, C., Zan, R., Yu, H., Yang, S., Zheng, X., Yang, J., Suo, T., Gu, Y., & Zhang, X. (2023). Research on the Current Application Status of Magnesium Metal Stents in Human Luminal Cavities. Journal of Functional Biomaterials, 14(9), 462. https://doi.org/10.3390/jfb14090462

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