Theoretical Model for In Vivo Induction of Chemotherapy Sensitization Using miRNA Packaged in Distinct Layered Liposomes

Cipu, Ruxandra-Ioana; Stănişteanu, Mihai-Laurențiu; Andrei, Mihaela-Aurelia; Banciu, Daniel Dumitru; Banciu, Adela

doi:10.3390/jfb15100298

Open AccessPerspective

Theoretical Model for In Vivo Induction of Chemotherapy Sensitization Using miRNA Packaged in Distinct Layered Liposomes

by

Ruxandra-Ioana Cipu

,

Mihai-Laurențiu Stănişteanu

,

Mihaela-Aurelia Andrei

,

Daniel Dumitru Banciu

^* and

Adela Banciu

Department of Biomaterials and Medical Devices, Faculty of Medical Engineering, National University of Science and Technology Politehnica Bucharest, 1-7 Gh. Polizu Street, 011061 Bucharest, Romania

^*

Author to whom correspondence should be addressed.

J. Funct. Biomater. 2024, 15(10), 298; https://doi.org/10.3390/jfb15100298

Submission received: 14 August 2024 / Revised: 1 October 2024 / Accepted: 3 October 2024 / Published: 5 October 2024

(This article belongs to the Collection Feature Papers in Biomaterials for Healthcare Applications)

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Abstract

Resistance to chemotherapy is a problem of major social and economic importance, when looking at factors like the decrease in life expectancy, the associated therapeutic costs, and a significant number of cancers that resist current chemotherapy. The development of chemotherapeutics for all theoretically possible tumor variants is an approach that requires unreasonable resources. We propose a theoretical model that serves the purpose of overcoming resistance to chemotherapeutic agents used in cancer therapy. The model describes a gene delivery system based on liposomes, which are optically guided to the tumor’s location. The main aim of the gene delivery system is inhibiting the activity of enzymes involved in drug metabolism, hence offering the opportunity to use inexpensive chemotherapeutics that are already on the market. This model will reduce the costs of chemotherapy and will assure a positive outcome for patients.

Keywords: chemotherapy; cancers; metabolism; treatment efficiency

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MDPI and ACS Style

Cipu, R.-I.; Stănişteanu, M.-L.; Andrei, M.-A.; Banciu, D.D.; Banciu, A. Theoretical Model for In Vivo Induction of Chemotherapy Sensitization Using miRNA Packaged in Distinct Layered Liposomes. J. Funct. Biomater. 2024, 15, 298. https://doi.org/10.3390/jfb15100298

AMA Style

Cipu R-I, Stănişteanu M-L, Andrei M-A, Banciu DD, Banciu A. Theoretical Model for In Vivo Induction of Chemotherapy Sensitization Using miRNA Packaged in Distinct Layered Liposomes. Journal of Functional Biomaterials. 2024; 15(10):298. https://doi.org/10.3390/jfb15100298

Chicago/Turabian Style

Cipu, Ruxandra-Ioana, Mihai-Laurențiu Stănişteanu, Mihaela-Aurelia Andrei, Daniel Dumitru Banciu, and Adela Banciu. 2024. "Theoretical Model for In Vivo Induction of Chemotherapy Sensitization Using miRNA Packaged in Distinct Layered Liposomes" Journal of Functional Biomaterials 15, no. 10: 298. https://doi.org/10.3390/jfb15100298

APA Style

Cipu, R.-I., Stănişteanu, M.-L., Andrei, M.-A., Banciu, D. D., & Banciu, A. (2024). Theoretical Model for In Vivo Induction of Chemotherapy Sensitization Using miRNA Packaged in Distinct Layered Liposomes. Journal of Functional Biomaterials, 15(10), 298. https://doi.org/10.3390/jfb15100298

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Theoretical Model for In Vivo Induction of Chemotherapy Sensitization Using miRNA Packaged in Distinct Layered Liposomes

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