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10.3390/jfb15020037
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Article

An Anti-Oxidative Bioink for Cartilage Tissue Engineering Applications

by
Xin Chen
1,
Mengni Yang
1,
Zheng Zhou
2,*,
Jingjing Sun
2,
Xiaolin Meng
1,
Yuting Huang
1,
Wenxiang Zhu
1,
Shuai Zhu
1,
Ning He
3,
Xiaolong Zhu
3,
Xiaoxiao Han
3 and
Hairong Liu
1,*
1
College of Material Science and Engineering, Hunan University, Changsha 410082, China
2
College of Biology, Hunan University, Changsha 410082, China
3
College of Mechanical and Vehicle Engineering, Hunan University, Changsha 410082, China
*
Authors to whom correspondence should be addressed.
J. Funct. Biomater. 2024, 15(2), 37; https://doi.org/10.3390/jfb15020037
Submission received: 11 December 2023 / Revised: 21 January 2024 / Accepted: 26 January 2024 / Published: 2 February 2024
(This article belongs to the Special Issue Advanced 3D Printing Biomaterials)
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Abstract

Since chondrocytes are highly vulnerable to oxidative stress, an anti-oxidative bioink combined with 3D bioprinting may facilitate its applications in cartilage tissue engineering. We developed an anti-oxidative bioink with methacrylate-modified rutin (RTMA) as an additional bioactive component and glycidyl methacrylate silk fibroin as a biomaterial component. Bioink containing 0% RTMA was used as the control sample. Compared with hydrogel samples produced with the control bioink, solidified anti-oxidative bioinks displayed a similar porous microstructure, which is suitable for cell adhesion and migration, and the transportation of nutrients and wastes. Among photo-cured samples prepared with anti-oxidative bioinks and the control bioink, the sample containing 1 mg/mL of RTMA (RTMA-1) showed good degradation, promising mechanical properties, and the best cytocompatibility, and it was selected for further investigation. Based on the results of 3D bioprinting tests, the RTMA-1 bioink exhibited good printability and high shape fidelity. The results demonstrated that RTMA-1 reduced intracellular oxidative stress in encapsulated chondrocytes under H2O2 stimulation, which results from upregulation of COLII and AGG and downregulation of MMP13 and MMP1. By using in vitro and in vivo tests, our data suggest that the RTMA-1 bioink significantly enhanced the regeneration and maturation of cartilage tissue compared to the control bioink, indicating that this anti-oxidative bioink can be used for 3D bioprinting and cartilage tissue engineering applications in the future.
Keywords: antioxidant; bioink; 3D bioprinting; rutin; cartilage tissue engineering antioxidant; bioink; 3D bioprinting; rutin; cartilage tissue engineering

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MDPI and ACS Style

Chen, X.; Yang, M.; Zhou, Z.; Sun, J.; Meng, X.; Huang, Y.; Zhu, W.; Zhu, S.; He, N.; Zhu, X.; et al. An Anti-Oxidative Bioink for Cartilage Tissue Engineering Applications. J. Funct. Biomater. 2024, 15, 37. https://doi.org/10.3390/jfb15020037

AMA Style

Chen X, Yang M, Zhou Z, Sun J, Meng X, Huang Y, Zhu W, Zhu S, He N, Zhu X, et al. An Anti-Oxidative Bioink for Cartilage Tissue Engineering Applications. Journal of Functional Biomaterials. 2024; 15(2):37. https://doi.org/10.3390/jfb15020037

Chicago/Turabian Style

Chen, Xin, Mengni Yang, Zheng Zhou, Jingjing Sun, Xiaolin Meng, Yuting Huang, Wenxiang Zhu, Shuai Zhu, Ning He, Xiaolong Zhu, and et al. 2024. "An Anti-Oxidative Bioink for Cartilage Tissue Engineering Applications" Journal of Functional Biomaterials 15, no. 2: 37. https://doi.org/10.3390/jfb15020037

APA Style

Chen, X., Yang, M., Zhou, Z., Sun, J., Meng, X., Huang, Y., Zhu, W., Zhu, S., He, N., Zhu, X., Han, X., & Liu, H. (2024). An Anti-Oxidative Bioink for Cartilage Tissue Engineering Applications. Journal of Functional Biomaterials, 15(2), 37. https://doi.org/10.3390/jfb15020037

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