Use of Antibiotics among Residents Living Close to Poultry or Goat Farms: A Nationwide Analysis in The Netherlands
Abstract
:1. Introduction
2. Results
2.1. Population Characteristics
2.2. Data on Antibiotic Use
2.3. Maps
2.4. Main Analyses
2.5. Sensitivity Analyses
3. Discussion
4. Materials and Methods
4.1. Study Design
4.2. Data on Livestock Farming
4.3. Antibiotic Prescription Data
4.4. Exclusion Criteria and Confounding Factors
4.5. Statistical Analysis
4.6. Sensitivity Analysis
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Variable | Percentage of UDPs * | ||||
---|---|---|---|---|---|
>0 Poultry Farms | 0 Poultry Farms | >0 Goat Farms | 0 Goat Farms | ||
Age | 15–24 | 13.0 | 13.1 | 13.0 | 13.1 |
25–44 | 25.9 | 26.1 | 25.8 | 26.1 | |
45–64 | 26.1 | 26.4 | 26.0 | 26.3 | |
65–74 | 13.0 | 13.1 | 12.9 | 13.1 | |
75+ | 22.1 | 21.4 | 22.4 | 21.5 | |
Gender | Male | 49.6 | 49.7 | 49.7 | 49.7 |
Female | 50.4 | 50.3 | 50.3 | 50.3 | |
SES | Low (<−0.22) | 20.0 | 18.1 | 10.9 | 20.7 |
Low-medium (≥−0.22 and <0.42) | 32.1 | 23.0 | 33.7 | 25.1 | |
Medium-high (≥−0.42 and <0.96) | 29.9 | 27.7 | 30.7 | 28.1 | |
High (≥0.96) | 18.1 | 31.2 | 24.7 | 26.1 | |
Smoking | Low (<17) | 22.8 | 17.4 | 28.0 | 17.7 |
Low-medium (≥17 and <19) | 38.3 | 37.0 | 39.1 | 37.1 | |
Medium-high (≥19 and <21) | 20.0 | 22.2 | 18.3 | 22.0 | |
High (≥21) | 18.9 | 23.5 | 14.6 | 23.2 | |
Urbanization | 3 (1000–1500 addresses per km2) | 10.8 | 22.5 | 10.7 | 19.4 |
4 (500–1000 addresses per km2) | 21.0 | 20.1 | 19.3 | 20.8 | |
5 (<500 addresses per km2) | 68.2 | 57.4 | 67.0 | 59.9 |
Variable | Mean DDD per 1000 Inhabitants | ||||
---|---|---|---|---|---|
Amoxicillin | Doxycycline | Co-Amoxiclav | Nitrofurantoin | ||
Age | 15–24 | 33.9 | 55.4 | 27.1 | 28.5 |
25–44 | 47.1 | 48.7 | 37.6 | 24.3 | |
45–64 | 55.3 | 64.9 | 48.5 | 34.6 | |
65–74 | 70.2 | 93.9 | 75.8 | 70.9 | |
75+ | 102.1 | 135.8 | 135.1 | 159.7 | |
Gender | Male | 59.0 | 78.8 | 72.6 | 19.5 |
Female | 65.8 | 78.4 | 57.8 | 105.8 | |
SES | Low (<−0.22) | 70.5 | 92.6 | 76.9 | 68.4 |
Low-medium (≥−0.22 and <0.42) | 65.2 | 83.9 | 68.7 | 66.6 | |
Medium-high (≥−0.42 and <0.96) | 59.5 | 73.4 | 63.2 | 60.9 | |
High (≥0.96) | 56.7 | 68.2 | 54.8 | 57.3 | |
Smoking | Low (<17) | 60.9 | 75.9 | 60.4 | 63.2 |
Low-medium (≥17 and <19) | 62.3 | 77.4 | 64.8 | 64.2 | |
Medium-high (≥19 and <21) | 61.4 | 80.8 | 65.0 | 60.6 | |
High (≥21) | 65.1 | 81.0 | 70.3 | 62.8 | |
Poultry farm presence | Yes | 65.2 | 84.8 | 68.2 | 65.2 |
No | 60.5 | 74.3 | 63.0 | 61.4 | |
Goat farm presence | Yes | 64.2 | 83.8 | 66.1 | 66.8 |
No | 62.0 | 77.4 | 64.9 | 62.0 |
Risk Factor | Amoxicillin RR (95% CI) | Doxycycline RR (95% CI) | Co-Amoxiclav RR (95% CI) | Nitrofurantoin RR (95% CI) |
---|---|---|---|---|
Presence of poultry farms | 1.11 (1.11–1.12) | 1.17 (1.17–1.18) | 1.14 (1.14–1.15) | 1.10 (1.09–1.11) |
Presence of goat farms | 1.14 (1.14–1.15) | 1.15 (1.15–1.16) | 1.15 (1.14–1.16) | 1.15 (1.14–1.16) |
Poultry Farm Presence | Crude Ratio * (95% CI) | Adjusted Ratio ** (95% CI) |
Amoxicillin | 1.08 *** (1.05–1.11) | 1.05 (1.02–1.08) |
Doxycycline | 1.15 (1.11–1.20) | 1.10 (1.06–1.14) |
Co-amoxiclav | 1.08 (1.05–1.12) | 1.05 (1.02–1.08) |
Nitrofurantoin | 1.06 (1.02–1.11) | 1.00 (0.96–1.04) |
Goat Farm Presence | Crude Ratio * (95% CI) | Adjusted Ratio ** (95% CI) |
Amoxicillin | 1.05 (1.00–1.08) | 1.02 (0.98–1.05) |
Doxycycline | 1.06 (1.01–1.12) | 1.03 (0.98–1.08) |
Co-amoxiclav | 1.02 (0.98–1.06) | 1.00 (0.96–1.03) |
Nitrofurantoin | 1.09 (1.03–1.15) | 1.03 (0.98–1.09) |
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Roof, I.; van der Hoek, W.; Oude Boerrigter, L.; Wielders, C.C.H.; Smit, L.A.M. Use of Antibiotics among Residents Living Close to Poultry or Goat Farms: A Nationwide Analysis in The Netherlands. Antibiotics 2021, 10, 1346. https://doi.org/10.3390/antibiotics10111346
Roof I, van der Hoek W, Oude Boerrigter L, Wielders CCH, Smit LAM. Use of Antibiotics among Residents Living Close to Poultry or Goat Farms: A Nationwide Analysis in The Netherlands. Antibiotics. 2021; 10(11):1346. https://doi.org/10.3390/antibiotics10111346
Chicago/Turabian StyleRoof, Inge, Wim van der Hoek, Lisette Oude Boerrigter, Cornelia C. H. Wielders, and Lidwien A. M. Smit. 2021. "Use of Antibiotics among Residents Living Close to Poultry or Goat Farms: A Nationwide Analysis in The Netherlands" Antibiotics 10, no. 11: 1346. https://doi.org/10.3390/antibiotics10111346