Increase and Change in the Pattern of Antibiotic Use in Serbia (2010–2019)
Abstract
:1. Introduction
2. Results
3. Discussion
4. Materials and Methods
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Antibiotic Class | Antibiotic Utilization (DID) per Year | Regression | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
2010 | 2011 | 2012 | 2013 | 2014 | 2015 | 2016 | 2017 | 2018 | 2019 | β | p | |
J01C | 5.68 | 7.70 | 7.97 | 7.58 | 9.41 | 11.47 | 8.63 | 6.70 | 8.29 | 11.26 | 0.532 | 0.113 |
J01D | 3.43 | 3.31 | 4.26 | 3.61 | 3.84 | 4.60 | 4.81 | 3.66 | 2.95 | 4.38 | 0.651 | 0.534 |
J01F | 3.23 | 5.12 | 4.01 | 4.06 | 3.93 | 5.82 | 5.04 | 3.67 | 5.16 | 5.54 | 0.505 | 0.137 |
J01M | 2.10 | 2.66 | 3.68 | 3.04 | 3.29 | 3.82 | 3.43 | 3.70 | 3.86 | 3.23 | 0.667 | 0.035 |
Quality Indicator | Year | Regression | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
2010 | 2011 | 2012 | 2013 | 2014 | 2015 | 2016 | 2017 | 2018 | 2019 | β | p | |
J01CE_% * | 1.08% | 0.00% | 0.72% | 0.47% | 0.94% | 0.41% | 0.39% | 0.39% | 0.33% | 0.26% | −0.57 | 0.086 |
J01CR_% * | 6.57% | 11.40% | 7.41% | 7.63% | 7.83% | 10.57% | 10.15% | 9.56% | 18.87% | 21.41% | 0.772 | 0.009 |
J01DD + J01DE_% * | 4.01% | 2.55% | 2.06% | 2.09% | 1.03% | 2.83% | 3.71% | 5.12% | 6.05% | 5.53% | 0.664 | 0.036 |
J01MA_% * | 6.64% | 7.49% | 11.35% | 8.94% | 10.17% | 10.11% | 11.05% | 14.79% | 14.30% | 11.16% | 0.786 | 0.007 |
J01_B/N | 1.42 | 2.34 | 1.37 | 1.92 | 1.15 | 2.07 | 1.95 | 2.39 | 6.00 | 4.16 | 0.692 | 0.027 |
ATC/DDD | 2010 | 2019 | % Change | β | Significance. |
---|---|---|---|---|---|
J01AA07-tetracycline | 0.12 | 0.02 | −82.42% | −0.85 | 0.002 |
J01AA12-tigecycline | 0.001 | 0.01 | 510.00% | 0.722 | 0.018 |
J01CR02-amoxicillin, clavulanic acid | 1.09 | 5.93 | 442.00% | 0.812 | 0.014 |
J01DB04-cefazolin | 0.02 | 0.09 | 331.50% | 0.643 | 0.045 |
J01DB05-cefadroxil | 0.04 | 0.10 | 161.63% | 0.728 | 0.064 |
J01DC04-cefaclor | 0.13 | 0.02 | −83.66% | −0.776 | 0.008 |
J01DD02-ceftazidime | 0.02 | 0.04 | 92.65% | 0.639 | 0.047 |
J01DD08-cefixime | 0.65 | 1.40 | 114.55% | 0.772 | 0.009 |
J01DD13-cefpodoxime | 0.04 * | 0.14 | 3296.25% | 0.847 | 0.008 |
J01FA06-roxithromycin | 0.5 | 0.12 | −76.71% | −0.662 | 0.037 |
J01FA09-clarithromycin | 0.94 | 1.64 | 74.79% | 0.814 | 0.004 |
J01FF01-clindamycin | 0.04 | 0.608 | 1421.00% | 0.888 | 0.001 |
J01GB03-gentamicin | 0.5 | 0.39 | −21.58% | −0.695 | 0.026 |
J01MA02-ciprofloxacin | 0.62 | 1.62 | 160.56% | 0.689 | 0.028 |
J01MA12-levofloxacin | 0.09 * | 1.33 | 1375.56% * | 0.919 | p < 0.001 |
J01MB04-pipemidic acid | 0.99 | 0.13 | −86.26% | −0.884 | 0.001 |
J01XA01-vancomycin | 0.03 | 0.051 | 70.00% | 0.717 | 0.020 |
J01XX01-fosfomycin | 0.02 | 0.095 | 373.20% | 0.931 | p < 0.001 |
J01XX08-linezolid | 0.0004 * | 0.006 | 1318.65% | 0.98 | p < 0.001 |
No. | 2010 | 2015 | 2019 | ||||||
---|---|---|---|---|---|---|---|---|---|
ATC INN | DID | % | ATC INN | DID | % | ATC INN | DID | % | |
1 | J01CA04-amoxicillin (A) | 3.09 | 17.93 | J01CA04-amoxicillin (A) | 7.68 | 25.89 | J01CR02-amoxicillin; clavulanic acid (A) | 5.93 | 20.70 |
2 | J01DB01-cefalexin (A) | 2.40 | 13.91 | J01DB01-cefalexin (A) | 3.60 | 12.14 | J01CA04-amoxicillin (A) | 4.96 | 17.30 |
3 | J01AA02-doxycycline (A) | 1.38 | 8.00 | J01FA10-azithromycin (Wa) | 3.19 | 10.76 | J01FA10-azithromycin (Wa) | 2.83 | 9.87 |
4 | J01CA01-ampicillin (A) | 1.31 | 7.59 | J01CR02-amoxicillin; clavulanic acid (A) | 3.06 | 10.31 | J01DB01-cefalexin (A) | 2.29 | 7.99 |
5 | J01FA10-azithromycin (Wa) | 1.27 | 7.36 | J01AA02-doxycycline (A) | 2.20 | 7.42 | J01FA09-clarithromycin (Wa) | 1.64 | 5.74 |
6 | J01CR02- amoxicillin, clavulanic acid (A) | 1.09 | 6.34 | J01MA02-ciprofloxacin (Wa) | 1.90 | 6.42 | J01MA02-ciprofloxacin (Wa) | 1.62 | 5.64 |
7 | J01MB04-pipemidic acid (NC) | 0.99 | 5.74 | J01FA09-clarithromycin (Wa) | 1.46 | 4.92 | J01AA02-doxycycline (A) | 1.47 | 5.12 |
8 | J01FA09-clarithromycin (Wa) | 0.94 | 5.45 | J01MB04-pipemidic acid (NC) | 0.90 | 3.03 | J01DD08-cefixime (Wa) | 1.39 | 4.87 |
9 | J01DD08-cefixime (Wa) | 0.65 | 3.77 | J01DD08-cefixime (Wa) | 0.77 | 2.60 | J01MA12-levofloxacin (Wa) | 1.33 | 4.64 |
10 | J01MA02-ciprofloxacin (Wa) | 0.62 | 3.59 | J01MA12-levofloxacin (Wa) | 0.74 | 2.49 | J01EE01-sulfamethoxazole; trimethoprim (A) | 0.89 | 3.10 |
11 | J01GB03-gentamicin (A) | 0.50 | 2.90 | J01CA01-ampicillin (A) | 0.61 | 2.06 | J01FF01-clindamycin (A) | 0.61 | 2.12 |
12 | J01FA06-roxithromycin (Wa) | 0.50 | 2.90 | J01GB03-gentamicin (A) | 0.61 | 2.06 | J01DD04-ceftriaxone (Wa) | 0.47 | 1.65 |
13 | J01DD04-ceftriaxone (Wa) | 0.40 | 2.32 | J01DC02-cefuroxime (Wa) | 0.41 | 1.45 | |||
14 | J01FA01-erythromycin (Wa) | 0.35 | 2.03 | ||||||
15 | J01MA06-norfloxacin (Wa) | 0.25 | 1.45 | ||||||
DU90% | 1–15 | 15.75 | 91.29 | 1–12 | 26.72 | 90.09 | 1–13 | 25.83 | 90.18 |
16–43 | 1.50 | 8.71 | 13–48 | 2.94 | 9.91 | 14–49 | 2.81 | 9.82 | |
Total | 43 | 17.25 | 100.00 | 48 | 29.66 | 100.00 | 49 | 28.65 | 100.00 |
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Tomas, A.; Pavlović, N.; Stilinović, N.; Horvat, O.; Paut-Kusturica, M.; Dugandžija, T.; Tomić, Z.; Sabo, A. Increase and Change in the Pattern of Antibiotic Use in Serbia (2010–2019). Antibiotics 2021, 10, 397. https://doi.org/10.3390/antibiotics10040397
Tomas A, Pavlović N, Stilinović N, Horvat O, Paut-Kusturica M, Dugandžija T, Tomić Z, Sabo A. Increase and Change in the Pattern of Antibiotic Use in Serbia (2010–2019). Antibiotics. 2021; 10(4):397. https://doi.org/10.3390/antibiotics10040397
Chicago/Turabian StyleTomas, Ana, Nebojša Pavlović, Nebojša Stilinović, Olga Horvat, Milica Paut-Kusturica, Tihomir Dugandžija, Zdenko Tomić, and Ana Sabo. 2021. "Increase and Change in the Pattern of Antibiotic Use in Serbia (2010–2019)" Antibiotics 10, no. 4: 397. https://doi.org/10.3390/antibiotics10040397