Benzothiazole-Containing Analogues of Triclocarban with Potent Antibacterial Activity
Abstract
:1. Introduction
2. Results and Discussion
2.1. Chemistry
2.2. Antibacterial Studies
3. Materials and Methods
3.1. Chemistry
3.2. Antibacterial In Vitro Evaluation
3.3. Cell Cultures
3.4. Cell Viability
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
References
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Microorganisms (MIC, µg/mL) | ||||||||
---|---|---|---|---|---|---|---|---|
Gram-Positive | Gram-Negative | |||||||
Compd | Structure | S.a. 25923 | S.a. 29213 | S.a. 6538 | S.a. 6538p | E.f. 29212 | P. a. 27853 | K.p. 13883 |
2eA | | nt | 64 | 32 | 16 | 32 | >256 | >256 |
2eB | | nt | 64 | 128 | A.N. | 32 | >256 | A.N. |
2bB | | nt | 16 | 128 | A.N. | 8 | >256 | A.N. |
2cC | | A.N. | >512 | A.N. | >512 | A.N. | A.N. | A.N. |
2bC | | 128 | 128 | 64 | 64 | 256 | >512 | >512 |
2bF | | 32 | 32 | 8 | 8 | 32 | >512 | >512 |
2eE | | 16 | 16 | 16 | 16 | 64 | >512 | >512 |
2eC | | 16 | 16 | 8 | 8 | 32 | >512 | >512 |
2dC | | 512 | 512 | 256 | 128 | 128 | >512 | >512 |
2bG a | | 32 | 32 | 64 | 64 | 32 | >512 | >512 |
NRF b | - | 0.5–2 | nt | nt | 2–8 | 1–4 | nt | |
TCC | 16 | 16 | 128 | 16 | 64 | 256 | 256 |
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Catalano, A.; Rosato, A.; Salvagno, L.; Iacopetta, D.; Ceramella, J.; Fracchiolla, G.; Sinicropi, M.S.; Franchini, C. Benzothiazole-Containing Analogues of Triclocarban with Potent Antibacterial Activity. Antibiotics 2021, 10, 803. https://doi.org/10.3390/antibiotics10070803
Catalano A, Rosato A, Salvagno L, Iacopetta D, Ceramella J, Fracchiolla G, Sinicropi MS, Franchini C. Benzothiazole-Containing Analogues of Triclocarban with Potent Antibacterial Activity. Antibiotics. 2021; 10(7):803. https://doi.org/10.3390/antibiotics10070803
Chicago/Turabian StyleCatalano, Alessia, Antonio Rosato, Lara Salvagno, Domenico Iacopetta, Jessica Ceramella, Giuseppe Fracchiolla, Maria Stefania Sinicropi, and Carlo Franchini. 2021. "Benzothiazole-Containing Analogues of Triclocarban with Potent Antibacterial Activity" Antibiotics 10, no. 7: 803. https://doi.org/10.3390/antibiotics10070803