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Article

Emergence of Fosfomycin Resistance by Plasmid-Mediated fos Genes in Uropathogenic ESBL-Producing E. coli Isolates in Mexico

by
Mario Galindo-Méndez
1,2,*,
Humberto Navarrete-Salazar
2,
Francisco Baltazar-Jiménez
2,
Eduardo Muñoz-de la Paz
2,
María Fernanda Sánchez-Mawcinitt
2,
Alexis Gómez-Pardo
3,
Elvira Garza-González
4,
Luis Alfredo Ponce-de-León-Garduño
5,
Rafael Franco-Cendejas
6,
Rayo Morfín-Otero
7,
Fabián Rojas-Larios
8,
Juan Pablo Mena-Ramírez
9,
Cecilia Teresita Morales-de-la-Peña
10,
Lourdes García-Mendoza
11,
Elena Victoria Choy-Chang
12,
Laura Karina Avilés-Benítez
13,
Eduardo López-Gutiérrez
14,
Jorge Luis Canizales-Oviedo
15,
Nicolás Eric Barlandas-Rendón
16,
Joyarib Yanelli Maldonado-Anicacio
17,
Alina Aracely Rosales-García
18 and
Heidy Leticia Ostos-Cantú
19add Show full author list remove Hide full author list
1
Laboratorios Galindo SC, Department of Microbiology, Oaxaca 68000, Mexico
2
School of Medicine, Universidad Anáhuac Oaxaca, San Raymundo Jalpan 71248, Mexico
3
Hospital General Balbuena, Ciudad de México 15970, Mexico
4
Hospital Universitario Dr. José E. González, Universidad Autónoma de Nuevo León, Monterrey 64460, Mexico
5
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México 14080, Mexico
6
Instituto Nacional de Rehabilitación Luis Guillermo Ibarra, Ciudad de México 14389, Mexico
7
Hospital Civil de Guadalajara e Instituto de Patología Infecciosa, Guadalajara 44280, Mexico
8
Hospital Regional Universitario de Colima, Colima 28085, Mexico
9
Hospital General de Zona 21 Tepatitlán De Morelos, Centro Universitario de los Altos (CUALTOS), Universidad de Guadalajara, Tepatitlán de Morelos 47620, Mexico
10
Hospital General con Especialidades Juan María de Salvatierra, La Paz 23085, Mexico
11
Hospital Angeles Valle Oriente, San Pedro Garza García 66260, Mexico
12
Hospital General de Zona No. 1, Tapachula 30700, Mexico
13
Hospital Infantil de Morelia, Morelia 58000, Mexico
14
Hospital Regional de Alta Especialidad de Oaxaca, San Bartolo Coyotepec 71256, Mexico
15
Laboratorio Pueblo Nuevo, Centro Universitario de Salud, Universidad Autónoma de Nuevo León, Monterrey 66455, Mexico
16
Laboratorio Bioclin, Chilpancingo 39000, Mexico
17
Hospital general de Chilpancingo, Chilpancingo 39019, Mexico
18
Hospital de Especialidades pediátrico de León, León 39900, Mexico
19
Bioclinsa, Hospital Ginequito, Monterrey 64060, Mexico
 
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*
Author to whom correspondence should be addressed.
Antibiotics 2022, 11(10), 1383; https://doi.org/10.3390/antibiotics11101383
Submission received: 8 September 2022 / Revised: 25 September 2022 / Accepted: 4 October 2022 / Published: 9 October 2022
(This article belongs to the Special Issue Antibiotic Treatment in Urinary Tract Infections (UTIs))
Versions Notes

Abstract

Fosfomycin is currently a viable option against urinary tract infections, particularly against extended-spectrum β-lactamases (ESBL)-producing E. coli, due to its unique mechanism of action and its low resistance among bacteria. The objective of this study was to investigate two of the three most common mechanisms of resistance against this antibiotic among 350 ESBL-producing E. coli strains isolated from the urine of Mexican patients. The prevalence of fosfomycin resistance in our study was 10.9% (38/350). Of all resistant isolates analyzed, 23 (60.5%) were identified as fos-producing organisms, with 14 strains carrying fosA3 and 9, fosA1. Additionally, 11 (28.9%) fosfomycin-resistant isolates presented resistance due to impaired antibiotic transport and 8 (21.0%) both mechanisms. No resistance mechanism investigated in the study was found on 12 strains. All 38 confirmed ESBL-producing isolates carried a blaCTX-M subtype, 36 (94.5%) belonged to the O25b-ST131 clone, and all of them were able to transfer the fosfomycin resistance trait to recipient strains horizontally. This is the first study in Mexico demonstrating a plasmid-mediated fosfomycin resistance mechanism among clinical E. coli strains. Since our results suggest a strong association among fos and blaCTX-M genes and ST131 clones in uropathogenic E. coli, plasmid-mediated fosfomycin resistance should be closely monitored.
Keywords: ESBL; antimicrobial resistance; fosfomycin resistance; CTX-M; ST131 ESBL; antimicrobial resistance; fosfomycin resistance; CTX-M; ST131

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MDPI and ACS Style

Galindo-Méndez, M.; Navarrete-Salazar, H.; Baltazar-Jiménez, F.; Muñoz-de la Paz, E.; Sánchez-Mawcinitt, M.F.; Gómez-Pardo, A.; Garza-González, E.; Ponce-de-León-Garduño, L.A.; Franco-Cendejas, R.; Morfín-Otero, R.; et al. Emergence of Fosfomycin Resistance by Plasmid-Mediated fos Genes in Uropathogenic ESBL-Producing E. coli Isolates in Mexico. Antibiotics 2022, 11, 1383. https://doi.org/10.3390/antibiotics11101383

AMA Style

Galindo-Méndez M, Navarrete-Salazar H, Baltazar-Jiménez F, Muñoz-de la Paz E, Sánchez-Mawcinitt MF, Gómez-Pardo A, Garza-González E, Ponce-de-León-Garduño LA, Franco-Cendejas R, Morfín-Otero R, et al. Emergence of Fosfomycin Resistance by Plasmid-Mediated fos Genes in Uropathogenic ESBL-Producing E. coli Isolates in Mexico. Antibiotics. 2022; 11(10):1383. https://doi.org/10.3390/antibiotics11101383

Chicago/Turabian Style

Galindo-Méndez, Mario, Humberto Navarrete-Salazar, Francisco Baltazar-Jiménez, Eduardo Muñoz-de la Paz, María Fernanda Sánchez-Mawcinitt, Alexis Gómez-Pardo, Elvira Garza-González, Luis Alfredo Ponce-de-León-Garduño, Rafael Franco-Cendejas, Rayo Morfín-Otero, and et al. 2022. "Emergence of Fosfomycin Resistance by Plasmid-Mediated fos Genes in Uropathogenic ESBL-Producing E. coli Isolates in Mexico" Antibiotics 11, no. 10: 1383. https://doi.org/10.3390/antibiotics11101383

APA Style

Galindo-Méndez, M., Navarrete-Salazar, H., Baltazar-Jiménez, F., Muñoz-de la Paz, E., Sánchez-Mawcinitt, M. F., Gómez-Pardo, A., Garza-González, E., Ponce-de-León-Garduño, L. A., Franco-Cendejas, R., Morfín-Otero, R., Rojas-Larios, F., Mena-Ramírez, J. P., Morales-de-la-Peña, C. T., García-Mendoza, L., Choy-Chang, E. V., Avilés-Benítez, L. K., López-Gutiérrez, E., Canizales-Oviedo, J. L., Barlandas-Rendón, N. E., ... Ostos-Cantú, H. L. (2022). Emergence of Fosfomycin Resistance by Plasmid-Mediated fos Genes in Uropathogenic ESBL-Producing E. coli Isolates in Mexico. Antibiotics, 11(10), 1383. https://doi.org/10.3390/antibiotics11101383

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