Early Years of Carbapenem-Resistant Enterobacterales Epidemic in Abu Dhabi
Abstract
:1. Introduction
2. Results
2.1. Characteristics of Collection and Coverage of CRE Studied
2.2. Characterization of Major Clones Present
2.3. Changing Rates of Major Clones, Resistance Genes, and Antibiotic Nonsusceptibility over Time
3. Discussion
4. Materials and Methods
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Characteristics | Genes, Clones or Resistance Features | % within the Collection | Alleles | % within the Enzyme Group | Year Encountered | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|
2009 | 2010 | 2011 | 2012 | 2013 | 2014 | 2015 | |||||
Resistance genes | blaNDM | 24.9 | blaNDM-1 | 89.8 | + | + | + | + | + | + | + |
blaNDM-4 | 1.0 | + | |||||||||
blaNDM-5 | 8.2 | + | + | ||||||||
blaNDM-7 | 1.0 | + | |||||||||
blaOXA-48-like | 43.9 | blaOXA-48 | 37.0 | + | + | + | + | + | + | + | |
blaOXA-162 | 1.7 | + | + | ||||||||
blaOXA-181 | 16.8 | + | + | + | |||||||
blaOXA-232 | 42.8 | + | + | + | |||||||
blaOXA-244 | 1.7 | + | + | + | |||||||
blaVIM | 0.8 | blaVIM-4 | 66.6 | + | + | ||||||
blaVIM-55 | 33.3 | + | |||||||||
blaNDM + blaOXA-48-like | 14.5 | blaNDM-1 + blaOXA-48 | 8.9 | + | + | ||||||
blaNDM-1 + blaOXA-162 | 1.8 | + | |||||||||
blaNDM-1 + blaOXA-181 | 3.6 | + | + | ||||||||
blaNDM-1 + blaOXA-232 | 73.2 | + | + | + | |||||||
blaNDM-5 + blaOXA-181 | 12.5 | + | + | + | |||||||
blaNDM-1 + blaVIM-55 | 0.3 | blaNDM-1 + blaVIM-55 | 100.0 | + | |||||||
Any MBL 1 | 40.4 | - | - | + | + | + | + | + | + | + | |
Any 16S methylase | 49.6 | armA | 30.5 | + | + | + | + | + | |||
rmtB | 1.3 | + | + | + | |||||||
rmtC | 1.3 | + | + | ||||||||
rmtF | 15.7 | + | + | + | + | ||||||
Resistance-related characteristics | XDR | 9.1 | - | - | + | + | + | + | + | + | |
PDR | 2.5 | - | - | + | + | + | + | ||||
Colistin R | 16.2 | - | - | + | + | + | + | + | |||
Tigecycline R | 57.6 | - | - | + | + | + | + | + | + | + | |
Ceftazidime–avibactam R | 40.6 | - | - | + | + | + | + | + | + | + | |
K. pneumoniae major clones | ST14 | 28.2 | - | - | + | + | + | + | |||
CC147 2 | 10.9 | - | - | + | + | + | + | ||||
ST231 | 11.1 | - | - | + | + |
Group | N | Rate (%) among | Presence in Hospitals 3 | |
---|---|---|---|---|
K. pneumoniae | All Strains | |||
ST14 | 111 | 34.3 | 28.2 | A, B, C, D, F |
CC147 1 | 43 | 13.3 | 10.9 | A, B, C, D, F |
ST231 | 36 | 11.1 | 9.1 | A, B, C, D, E |
All major clones | 190 | 58.6 | 48.2 | A, B, C, D, E, F |
Sporadic 2 K. pneumoniae | 134 | 41.4 | 34.0 | A, B, C, D, E, F |
Groups | N | Rate (%) of | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Resistance Genes | Nonsusceptibility to | Resistance-Related Parameters | ||||||||||||
blaNDM | blaOXA-48-like | blaNDM + blaOXA-48-like | MBL 3 | Any 16S Methylase | armA | rmtF | Ceftazidime-Avibactam | Colistin | Tigecycline | Meropenem MIC > 8 mg/L | XDR or PDR | R Index | ||
ST14 | 111 | 30.3 | 36.9 | 32.4 | 63.1 | 78.4 | 78.4 | 0 | 67.6 | 26.1 | 75.7 | 89.2 | 33.3 | 13.02 ± 1.29 |
ST231 | 36 | 0.0 | 97.2 | 0.0 | 0.0 | 100.0 | 5.6 | 97.2 | 0.0 | 5.6 | 100.0 | 91.7 | 0.0 | 12.27 ± 0.77 |
CC147 1 | 43 | 34.9 | 37.2 | 14.0 | 48.8 | 51.2 | 11.6 | 39.5 | 48.8 | 14.0 | 72.1 | 86.1 | 9.3 | 11.67 ± 2.51 |
Sporadic 2 strains | 134 | 12.8 | 30.1 | 3.9 | 17.2 | 12.2 | 7.8 | 2.5 | 17.7 | 9.3 | 30.0 | 30.0 | 2.0 | 10.35 ± 2.63 |
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Pál, T.; Butt, A.B.; Ghazawi, A.; Thomsen, J.; Rizvi, T.A.; Sonnevend, Á. Early Years of Carbapenem-Resistant Enterobacterales Epidemic in Abu Dhabi. Antibiotics 2022, 11, 1435. https://doi.org/10.3390/antibiotics11101435
Pál T, Butt AB, Ghazawi A, Thomsen J, Rizvi TA, Sonnevend Á. Early Years of Carbapenem-Resistant Enterobacterales Epidemic in Abu Dhabi. Antibiotics. 2022; 11(10):1435. https://doi.org/10.3390/antibiotics11101435
Chicago/Turabian StylePál, Tibor, Aqdas B. Butt, Akela Ghazawi, Jens Thomsen, Tahir A. Rizvi, and Ágnes Sonnevend. 2022. "Early Years of Carbapenem-Resistant Enterobacterales Epidemic in Abu Dhabi" Antibiotics 11, no. 10: 1435. https://doi.org/10.3390/antibiotics11101435