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Volume 12
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10.3390/antibiotics12020195
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Review

Uncovering the Secretion Systems of Acinetobacter baumannii: Structures and Functions in Pathogenicity and Antibiotic Resistance

by
Pu Li
1,
Sirui Zhang
2,
Jingdan Wang
1,
Mona Mohamed Al-Shamiri
2,
Bei Han
1,
Yanjiong Chen
2,
Shaoshan Han
3 and
Lei Han
2,*
1
School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an 710061, China
2
Department of Microbiology and Immunology, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Xi’an 710061, China
3
Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China
*
Author to whom correspondence should be addressed.
Antibiotics 2023, 12(2), 195; https://doi.org/10.3390/antibiotics12020195
Submission received: 22 November 2022 / Revised: 6 January 2023 / Accepted: 16 January 2023 / Published: 17 January 2023
(This article belongs to the Special Issue Molecular Characterization of Gram-Negative Bacteria: Antimicrobial Resistance, Virulence and Epidemiology)
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Abstract

Infections led by Acinetobacter baumannii strains are of great concern in healthcare environments due to the strong ability of the bacteria to spread through different apparatuses and develop drug resistance. Severe diseases can be caused by A. baumannii in critically ill patients, but its biological process and mechanism are not well understood. Secretion systems have recently been demonstrated to be involved in the pathogenic process, and five types of secretion systems out of the currently known six from Gram-negative bacteria have been found in A. baumannii. They can promote the fitness and pathogenesis of the bacteria by releasing a variety of effectors. Additionally, antibiotic resistance is found to be related to some types of secretion systems. In this review, we describe the genetic and structural compositions of the five secretion systems that exist in Acinetobacter. In addition, the function and molecular mechanism of each secretion system are summarized to explain how they enable these critical pathogens to overcome eukaryotic hosts and prokaryotic competitors to cause diseases.
Keywords: Acinetobacter baumannii; secretion systems; pathogenicity; antibiotic resistance Acinetobacter baumannii; secretion systems; pathogenicity; antibiotic resistance

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MDPI and ACS Style

Li, P.; Zhang, S.; Wang, J.; Al-Shamiri, M.M.; Han, B.; Chen, Y.; Han, S.; Han, L. Uncovering the Secretion Systems of Acinetobacter baumannii: Structures and Functions in Pathogenicity and Antibiotic Resistance. Antibiotics 2023, 12, 195. https://doi.org/10.3390/antibiotics12020195

AMA Style

Li P, Zhang S, Wang J, Al-Shamiri MM, Han B, Chen Y, Han S, Han L. Uncovering the Secretion Systems of Acinetobacter baumannii: Structures and Functions in Pathogenicity and Antibiotic Resistance. Antibiotics. 2023; 12(2):195. https://doi.org/10.3390/antibiotics12020195

Chicago/Turabian Style

Li, Pu, Sirui Zhang, Jingdan Wang, Mona Mohamed Al-Shamiri, Bei Han, Yanjiong Chen, Shaoshan Han, and Lei Han. 2023. "Uncovering the Secretion Systems of Acinetobacter baumannii: Structures and Functions in Pathogenicity and Antibiotic Resistance" Antibiotics 12, no. 2: 195. https://doi.org/10.3390/antibiotics12020195

APA Style

Li, P., Zhang, S., Wang, J., Al-Shamiri, M. M., Han, B., Chen, Y., Han, S., & Han, L. (2023). Uncovering the Secretion Systems of Acinetobacter baumannii: Structures and Functions in Pathogenicity and Antibiotic Resistance. Antibiotics, 12(2), 195. https://doi.org/10.3390/antibiotics12020195

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