Effect of Surface Modification on the Primary Stability of Dental Implants by Plasma Oxidation and Storage Treatment
Round 1
Reviewer 1 Report
Dear authors,
the paper deals with the interesting topic of surface modification of dental implants, however the originality and significance of the work are not well evidenced.
In particular why the here proposed treatment can be better that the commercial SLA-active one?
Are there any risk of toxicity or irritant effect due to the alkaline storage compared to the physiological solution one?
Which are the advantages of the here proposed plasma treatment over the conventional ones used for decontamination of commercial dental implants?
Specific suggestions in are listed below:
- Introduction, pag. 2 "Ag/Zn injection" is not clear. Antibacterial activity should be cited.
- in contact angle measurement NaOH added for stored samples is let to dry? Did you consider the effect of NaOH chemistry on wettability?
- Are stored samples washed before cellular and in vivo tests? Please specify. if not can the NaOH have toxic/irritant effects? please comment
- is the reported difference in roughness significant? please discuss
- Fig 2 indicate the surface to which it refers
- In XPS analyses the oxygen signal and a discussion on OH groups should be added
- In the discussion you mention IEP and surface charge but no data are presented, please add or cite proper references.
Author Response
Please see the attachment
Author Response File: 
Author Response.pdf
Reviewer 2 Report
This investigation is a paper that presents information for researchers in the field of surface of dental implants. This study assesses the results of using alkali storage and a treatment with plasma oxidation for improve the primary implant stability.
Introduction. This section showes the importance of the improvement of surface biological activity results from changes in morphology and surface chemical properties. Plasma modification and implantation are recent developments in surface modification that can be used to enhance the surface properties of materials without altering their original morphology. Using oxygen plasma treatment can improve the osseointegration of Ti and enhance corrosion resistance.
The degradation process of surface implants may come from the adsorption of hydrocarbons, and surface-treated implants may take a long time for clinical applications, so some wet storing techniques were developed to solve this problem. Therefore, changes in surface chemical properties and effects in stored procedures should also be considered.
Material and methods. This section is adequated scientifically.
Results are correct and well structured. Experimental results (surface characterization, cell responses,) not found differences between SLA, oxidation and storage samples. In the animal experimentation, storage implants improves the osseointegration level with a higher removal torque value and bone implant contact ratios than the SLA implants.
Discussion. This section must be improved. It must to include discussion with more recent experimental and clinical studies for practice applications.
The section Conclusions is adequated.
References. The references include only 8 papers (21%) of last five years
Conclusively, the study is not ready for publication.
Author Response
Please see the attament
Author Response File: Author Response.pdf
Round 2
Reviewer 2 Report
The modifications are correct.
