Application of Optical Fiber Sensing Technology and Coating Technology in Blood Component Detection and Monitoring

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

The Review Report for Coatings-2810884 “Application of optical fiber sensing technology and coating technology in blood component detection and monitoring“

In this manuscript, the authors discussed mainly the following four points: (1) the current situation and development trend of optical sensing technology, (2) coating of optical fiber to detect something, (3) the advantages and limitations of different sensor design schemes, and (4) challenges and future directions of fiber-optic sensors in the medical field.

The manuscript looked well organized. The latest research results are also clearly organized. In addition, a sufficient amount of literature is cited.

The reviewer sees no problem with publishing this manuscript as it is.

Author Response

Thank you for your thoughtful comments and positive feedback on our manuscript. We appreciate your careful consideration of the key points we discussed. Your positive evaluation motivates us, and we are grateful for your support.

If you have any specific recommendations or further details you would like us to address, please feel free to provide additional feedback. Once again, thank you for your time and valuable comments.

Reviewer 2 Report

Comments and Suggestions for Authors

The reviewed paper describes the use of optical sensors in the quantification of blood components. The topic taken up by the authors is current due to the increasing number of analyses performed in many medical laboratories. Furthermore, the paper presents the application of optical sensors in a very clear and transparent manner starting with basic information on their use for the quantification of individual blood components. This is a very good approach as it presents the problem addressed from start to finish, i.e. from basics to advanced applications. Only in the Introduction I miss the indication to the readers that there are other available sensors used in the analysis of human body fluids. It seems to me that a brief characterisation of the currently available methods for determining blood components with other types of sensors would have been desirable. Generally, the overall layout of the paper is logical and needs no improvement. However, I miss the clearly presented analytical parameters of the sensors presented. I request that the parameters of the sensors published in the last 10 years are presented in table form.

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 3 Report

Comments and Suggestions for Authors

The review contains many published examples of optical fiber sensors for detection of blood components. The principles of optical fiber sensing are explained too shortly. There are not distinguished sensors on the tip of optical fiber, evanescent, plasmon and other types of sensors. From the point of view of optical fiber coating, they differ substantially. There are reviews of optical fiber chemical and bio-sensors that can be used as a base. The advantages and disadvantages of various coating techniques for certain type of sensor should be shown. Protective coatings of optical fibers are applied in the length of kilometers in contrast to meters or millimeters for sensing coating.  I propose to improve readability of the text by arrangement of the part of the text into tables. A comparison of optical fiber coatings for sensing technology should be added.

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 4 Report

Comments and Suggestions for Authors

The article titled "Application of Optical Fiber Sensing Technology and Coating Technology in Blood Component Detection and Monitoring" is a comprehensive examination of the integration of optical fiber sensing and coating technologies in the medical field, particularly for blood component analysis. It highlights the advancements, applications, and future prospects of these technologies in medical diagnostics and health monitoring.

Pros:

1.      Innovative Approach: The article provides a detailed overview of how optical fiber sensors, when combined with various coating technologies, enhance the detection and monitoring of blood components. This innovative approach presents new possibilities in medical diagnostics.

2.      Comprehensive Coverage: It covers a wide range of applications, including blood glucose concentration, blood pH, and protein detection, offering a broad perspective on the potential of these technologies in healthcare.

Cons:

1.      Technical Complexity: The article is highly technical, which might be challenging for readers without a background in optical fiber technology or medical engineering.

2.      Limited Practical Examples: There's a lack of real-world examples or case studies demonstrating the application of these technologies in clinical settings.

3.      Potential Bias: The focus is predominantly on the positive aspects and potential of technology, with limited discussion of its limitations or challenges in practical implementation.

4.      Cost and Accessibility Issues: The article does not address the cost-effectiveness or accessibility of these technologies, which are crucial factors for widespread adoption in healthcare.

5.      Insufficient Comparative Analysis: There's a lack of comparison with existing technologies, which would help in understanding the relative advantages or improvements.

6.      Future Directions Unclear: While the article discusses current applications, it does not provide a clear roadmap for future research or development in this field.

7.      Lack of Diverse Perspectives: The article could benefit from including diverse perspectives, such as those from clinicians, patients, or healthcare policymakers.

8.      Limited Focus on Ethical Considerations: Ethical implications of advanced sensing technologies in healthcare are not thoroughly explored.

9.      Potential Overemphasis on Technology: There might be an overemphasis on technological solutions, while overlooking other aspects of patient care and medical diagnostics.

Additional comments: -

1. Page 2, Line 44: "Optical fiber sensors have the advantages of miniaturization, strong anti-interference ability, high sensitivity, low cost, fast response speed, and can be used in situ detection in harsh environment etc., which has a wide application prospect in blood detection and monitoring, providing new possibilities for medical diagnosis and health monitoring."
• Error: Punctuation and conjunction issues. The sentence is overly long and complex, making it hard to follow.
2. Page 2, Line 46-47: "On the other hand, coating technology can increase the sensitivity and stability of optical fiber sensors, improve their measurement accuracy and reliability."
• Error: Fragmented sentence. The phrase "On the other hand" typically contrasts a previous statement, but here it starts a new thought without clear reference to a preceding contrasting point.
3. Page 3, Line 104-106: "Optical fiber sensor technology is widely used in the medical field especially in the detection of various substances and parameters in blood."
• Error: Missing commas. It should be: "Optical fiber sensor technology is widely used in the medical field, especially in the detection of various substances and parameters in blood."
4. Page 3, Line 107: "As a vital part of the fluid environment in the human body blood carries oxygen, nutrients, hormones, and waste products and reflects important information about the state of human health."
• Error: Missing comma after "body".
5. Page 3, Line 108-109: "Abnormal blood vessel wall thickness, blood flow velocity, and parameters such as contraction and dilation or certain substances such as cholesterol and hormones that exceed threshold values are closely related to hypertension, arteriosclerosis, cardiovascular disease, and many other diseases[12]."
• Error: The sentence is overly long and complex, which may confuse the reader.
6. Page 3, Line 114-115: "Traditional blood testing methods which typically require blood samples to be collected and then analyzed in a lab are not only time-consuming but can also cause discomfort to patients due to wounds."
• Error: Missing comma after "methods".
7. Page 4, Line 146-147: "In the detection of various substances and parameters in blood, fiber optic sensors have made remarkable progress."
• Error: The sentence structure is awkward and could be more concise.
8. Page 5, Line 245-247: "As an emerging sensor technology, fiber sensor technology has many advantages such as high sensitivity, fast response, miniaturization, no electromagnetic interference, suitable for interventional detection, and other characteristics so it has great potential in medical applications."
• Error: Punctuation and structure issues. The sentence is too long and would benefit from being split into two sentences for clarity.
9. Page 6, Line 321-322: "Fiber optic sensors play a key role in blood testing by utilizing optical principles to achieve highly sensitive monitoring of blood composition and properties."
• Error: Redundancy in phrase "highly sensitive monitoring" and "optical principles". Could be simplified for clarity.
10. Page 7, Line 467-469: "The biosensor based on FPI end resonator can detect the concentration of protein aggregates simply, quickly, and effectively."
• Error: Sentence structure and clarity. The phrase "simply, quickly, and effectively" is vague and adds little value to the sentence.

Comments for author File: Comments.docx

Comments on the Quality of English Language

Check for grammar errors and syntax errors

Author Response

Please see the attachment.

Author Response File: Author Response.pdf