GARP: A Key Target to Evaluate Tumor Immunosuppressive Microenvironment
Abstract
:Simple Summary
Abstract
1. Introduction
2. GARP Expression, Structure and Function
2.1. GARP Expression
2.2. GARP Structure
2.3. GARP Promotes the Activation of Biologically Active TGF-β
3. GARP in Cancer
3.1. GARP and Cancer Cells
3.2. GARP and Cells of the TME
3.2.1. Tregs
3.2.2. Platelets
3.2.3. Other Cells
3.3. Soluble GARP
3.3.1. Modulation of T-Cell Function by Soluble GARP
3.3.2. sGARP Influences the Polarization of Macrophages
4. GARP as a Therapeutic Target in Cancer
5. GARP as a Biomarker in Cancer: Perspectives
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Bouchard, A.; Collin, B.; Garrido, C.; Bellaye, P.-S.; Kohli, E. GARP: A Key Target to Evaluate Tumor Immunosuppressive Microenvironment. Biology 2021, 10, 836. https://doi.org/10.3390/biology10090836
Bouchard A, Collin B, Garrido C, Bellaye P-S, Kohli E. GARP: A Key Target to Evaluate Tumor Immunosuppressive Microenvironment. Biology. 2021; 10(9):836. https://doi.org/10.3390/biology10090836
Chicago/Turabian StyleBouchard, Alexanne, Bertrand Collin, Carmen Garrido, Pierre-Simon Bellaye, and Evelyne Kohli. 2021. "GARP: A Key Target to Evaluate Tumor Immunosuppressive Microenvironment" Biology 10, no. 9: 836. https://doi.org/10.3390/biology10090836