Mediators of Host–Microbe Circadian Rhythms in Immunity and Metabolism
Round 1
Reviewer 1 Report
The review by Frazie et al., comprehensively describe the cross-talk between circadian rhythms and gut microbiota, and the subsequent influence on host metabolism and immune function. The review is clearly written and well organized in different sections relevant to the topic. Different possible mediators of the microbiota-circadian rhythms interaction are also properly analysed. Moreover, the literature has been correctly cited.
Thus, I believe the quality of this review is good and should be published in “Biology”, since it fits with the standard and mission of the journal.
Reviewer 2 Report
This is an extremely interesting review on how the rhythmicity of gut microbes is essential for the host metabolic health. The authors discuss how the host imune system may be the link between the mutual signaling of microbes and the metabolic functions, allowing a syncrony between their rhythms. Evidences are given for the most probable candidate molecules to signal circadian clues between environment, gut microbes and the imune system.
The manuscript is well written, it covers a broad and recent literature, and raises intriguing questions about the theme.
