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Biology
Volume 9
Issue 6
10.3390/biology9060123
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Article

Molecular Aggregation in Immune System Activation Studied by Dynamic Light Scattering

by
Elena Velichko
1,*,
Sergey Makarov
1,
Elina Nepomnyashchaya
1 and
Ge Dong
2,*
1
Institute of Physics, Nanotechnology and Telecommunications, Peter the Great St.Petersburg Polytechnic University, St. Petersburg 195251, Russia
2
School of Aerospace Engineering, Tsinghua University, Beijing 100084, China
*
Authors to whom correspondence should be addressed.
Biology 2020, 9(6), 123; https://doi.org/10.3390/biology9060123
Submission received: 28 April 2020 / Revised: 28 May 2020 / Accepted: 7 June 2020 / Published: 12 June 2020
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Abstract

Determination of the concentration and size of the circulating immune complexes in the blood is an essential part of diagnostics of immune diseases. In this work, we suggest using the dynamic light scattering method to determine the sizes of circulating immune complexes in blood serum. By the dynamic light scattering spectrometer, we found that for healthy and sick donors, the size and concentration of circulating immune complexes differed significantly. The dynamics of formation of these complexes were also examined in this work. It was shown that the formation of immune complexes in the blood of healthy donors is faster than the same reactions in the blood serum of donors with diseases. The results can be used in the diagnostics of the immune status and detection of chronic inflammation. We can recommend the dynamic light scattering method for implementation in biomedical diagnostics.
Keywords: dynamic light scattering; humoral immune system; immune complexes; immune diagnostics dynamic light scattering; humoral immune system; immune complexes; immune diagnostics

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MDPI and ACS Style

Velichko, E.; Makarov, S.; Nepomnyashchaya, E.; Dong, G. Molecular Aggregation in Immune System Activation Studied by Dynamic Light Scattering. Biology 2020, 9, 123. https://doi.org/10.3390/biology9060123

AMA Style

Velichko E, Makarov S, Nepomnyashchaya E, Dong G. Molecular Aggregation in Immune System Activation Studied by Dynamic Light Scattering. Biology. 2020; 9(6):123. https://doi.org/10.3390/biology9060123

Chicago/Turabian Style

Velichko, Elena, Sergey Makarov, Elina Nepomnyashchaya, and Ge Dong. 2020. "Molecular Aggregation in Immune System Activation Studied by Dynamic Light Scattering" Biology 9, no. 6: 123. https://doi.org/10.3390/biology9060123

APA Style

Velichko, E., Makarov, S., Nepomnyashchaya, E., & Dong, G. (2020). Molecular Aggregation in Immune System Activation Studied by Dynamic Light Scattering. Biology, 9(6), 123. https://doi.org/10.3390/biology9060123

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