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Biology, Volume 9, Issue 6

2020 June - 30 articles

Cover Story: Invertebrates show more variation in muscle organization than vertebrates. The Procambarus clarkii opener muscle has three phenotypic regions (distal, central, proximal) yet is innervated by only one excitatory neuron. These regions have varied biochemistry and physiology. Central fibers generate the largest force with the longest sarcomeres; however, serotonin does not increase force generated by central fibers more than other regions. This finding was surprising since tension receptors sensing the shearing forces are located at the distal end of the apodeme (cuticle invagination). This study demonstrates the malleability of the motor unit. View this paper.
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Articles (30)

  • Article
  • Open Access
32 Citations
5,436 Views
16 Pages

Kinematic Sub-Populations in Bull Spermatozoa: A Comparison of Classical and Bayesian Approaches

  • Luis Víquez,
  • Vinicio Barquero,
  • Carles Soler,
  • Eduardo R.S. Roldan and
  • Anthony Valverde

26 June 2020

The ejaculate is heterogenous and sperm sub-populations with different kinematic patterns can be identified in various species. Nevertheless, although these sub-populations are statistically well defined, the statistical differences are not always re...

  • Article
  • Open Access
23 Citations
7,412 Views
15 Pages

Spectral Distribution of Ultra-Weak Photon Emission as a Response to Wounding in Plants: An In Vivo Study

  • Ankush Prasad,
  • Prabhakar Gouripeddi,
  • Hanumanth Rao Naidu Devireddy,
  • Alina Ovsii,
  • Dattatreya Prabhu Rachakonda,
  • Roeland Van Wijk and
  • Pavel Pospíšil

26 June 2020

It is well established that every living organism spontaneously emits photons referred to as ultra-weak photon emission (synonym biophotons or low-level chemiluminescence) which inherently embodies information about the wellbeing of the source. In re...

  • Review
  • Open Access
4 Citations
6,737 Views
21 Pages

Mass Spectrometry to Study Chromatin Compaction

  • Stephanie Stransky,
  • Jennifer Aguilan,
  • Jake Lachowicz,
  • Carlos Madrid-Aliste,
  • Edward Nieves and
  • Simone Sidoli

26 June 2020

Chromatin accessibility is a major regulator of gene expression. Histone writers/erasers have a critical role in chromatin compaction, as they “flag” chromatin regions by catalyzing/removing covalent post-translational modifications on hi...

  • Review
  • Open Access
15 Citations
7,633 Views
12 Pages

Lessons from SARS-CoV-2 Pandemic: Evolution, Disease Dynamics and Future

  • Saurabh Pandey,
  • Bharat Yadav,
  • Arvind Pandey,
  • Takshashila Tripathi,
  • Masuma Khawary,
  • Sashi Kant and
  • Deeksha Tripathi

26 June 2020

The COVID-19 pandemic is rising at an unprecedented rate. The surging number of deaths every day, global lockdown and travel restrictions have resulted in huge losses to society. The impact is massive and will leave a historical footprint. The Spanis...

  • Article
  • Open Access
11 Citations
3,566 Views
13 Pages

Termite Societies Promote the Taxonomic and Functional Diversity of Archaeal Communities in Mound Soils

  • Monde Wakung’oli,
  • Adenike Eunice Amoo,
  • Ben Jesuorsemwen Enagbonma and
  • Olubukola Oluranti Babalola

25 June 2020

Recent studies involving microbial communities in termite mounds have been more focused on bacteria and fungi with little attention given to archaea, which play significant roles in nutrient cycling. Thus, we aimed at characterizing the archaeal taxo...

  • Review
  • Open Access
101 Citations
6,488 Views
14 Pages

The Role of Mitochondria in Cardiovascular Diseases

  • Anastasia V. Poznyak,
  • Ekaterina A. Ivanova,
  • Igor A. Sobenin,
  • Shaw-Fang Yet and
  • Alexander N. Orekhov

25 June 2020

The role of mitochondria in cardiovascular diseases is receiving ever growing attention. As a central player in the regulation of cellular metabolism and a powerful controller of cellular fate, mitochondria appear to comprise an interesting potential...

  • Article
  • Open Access
21 Citations
4,961 Views
11 Pages

24 June 2020

This article describes a simple Susceptible Infected Recovered (SIR) model fitting with COVID-19 data for the month of March 2020 in New York (NY) state. The model is a classical SIR, but is non-autonomous; the rate of susceptible people becoming inf...

  • Article
  • Open Access
3 Citations
3,734 Views
10 Pages

Laboratory Diagnostics of Rickettsia Infections in Denmark 2008–2015

  • Susanne Schjørring,
  • Martin Tugwell Jepsen,
  • Camilla Adler Sørensen,
  • Palle Valentiner-Branth,
  • Bjørn Kantsø,
  • Randi Føns Petersen,
  • Ole Skovgaard and
  • Karen A. Krogfelt

19 June 2020

Rickettsiosis is a vector-borne disease caused by bacterial species in the genus Rickettsia. Ticks in Scandinavia are reported to be infected with Rickettsia, yet only a few Scandinavian human cases are described, and rickettsiosis is poorly understo...

  • Article
  • Open Access
18 Citations
5,023 Views
21 Pages

Unreported Cases for Age Dependent COVID-19 Outbreak in Japan

  • Quentin Griette,
  • Pierre Magal and
  • Ousmane Seydi

17 June 2020

We investigate the age structured data for the COVID-19 outbreak in Japan. We consider a mathematical model for the epidemic with unreported infectious patient with and without age structure. In particular, we build a new mathematical model and a new...

  • Letter
  • Open Access
13 Citations
8,128 Views
4 Pages

16 June 2020

Previous studies have found large variations in the COVID-19 infection fatality rate (IFR). This study hypothesized that IFR would be influenced by COVID-19 epidemic intensity. We tested the association between epidemic intensity and IFR using serolo...

  • Article
  • Open Access
5 Citations
5,536 Views
17 Pages

Norpa Signalling and the Seasonal Circadian Locomotor Phenotype in Drosophila

  • Carlo Breda,
  • Ezio Rosato and
  • Charalambos P. Kyriacou

16 June 2020

In this paper, we review the role of the norpA-encoded phospholipase C in light and thermal entrainment of the circadian clock in Drosophila melanogaster. We extend our discussion to the role of norpA in the thermo-sensitive splicing of the per 3&pri...

  • Article
  • Open Access
95 Citations
6,987 Views
16 Pages

Oral Microbiota and Immune System Crosstalk: A Translational Research

  • Andrea Ballini,
  • Gianna Dipalma,
  • Ciro Gargiulo Isacco,
  • Mariarosaria Boccellino,
  • Marina Di Domenico,
  • Luigi Santacroce,
  • Kieu C.D. Nguyễn,
  • Salvatore Scacco,
  • Maura Calvani and
  • Francesco Inchingolo
  • + 5 authors

16 June 2020

Background: Oral pathogens may exert the ability to trigger differently the activation of local macrophage immune responses, for instance Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans induce predominantly pro-inflammatory (M1-lik...

  • Article
  • Open Access
58 Citations
13,394 Views
14 Pages

Lymphoid Tissue in Teleost Gills: Variations on a Theme

  • Julien Rességuier,
  • Alf S. Dalum,
  • Louis Du Pasquier,
  • Yaqing Zhang,
  • Erling Olaf Koppang,
  • Pierre Boudinot and
  • Geert F. Wiegertjes

15 June 2020

In bony fish, the gill filaments are essential for gas exchanges, but also are vulnerable to infection by water-borne microorganisms. Omnipresent across fish, gill-associated lymphoid tissues (GIALT) regulate interactions with local microbiota and ha...

  • Communication
  • Open Access
6 Citations
3,834 Views
6 Pages

12 June 2020

Veno-arterial extracorporeal membrane oxygenation (V-A ECMO) preserves the life of heart failure patients by providing an adequate oxygen supply and blood flow to vital organs. For patients with severe cardiogenic shock secondary to acute myocardial...

  • Review
  • Open Access
30 Citations
5,721 Views
17 Pages

Revisiting the Impact of Neurodegenerative Proteins in Epilepsy: Focus on Alpha-Synuclein, Beta-Amyloid, and Tau

  • Yam Nath Paudel,
  • Efthalia Angelopoulou,
  • Christina Piperi,
  • Iekhsan Othman and
  • Mohd. Farooq Shaikh

12 June 2020

Lack of disease-modifying therapy against epileptogenesis reflects the complexity of the disease pathogenesis as well as the high demand to explore novel treatment strategies. In the pursuit of developing new therapeutic strategies against epileptoge...

  • Article
  • Open Access
20 Citations
7,375 Views
13 Pages

Molecular Aggregation in Immune System Activation Studied by Dynamic Light Scattering

  • Elena Velichko,
  • Sergey Makarov,
  • Elina Nepomnyashchaya and
  • Ge Dong

12 June 2020

Determination of the concentration and size of the circulating immune complexes in the blood is an essential part of diagnostics of immune diseases. In this work, we suggest using the dynamic light scattering method to determine the sizes of circulat...

  • Review
  • Open Access
25 Citations
6,339 Views
17 Pages

Soluble Epoxide Hydrolase Inhibition in Liver Diseases: A Review of Current Research and Knowledge Gaps

  • Jeffrey Warner,
  • Josiah Hardesty,
  • Kara Zirnheld,
  • Craig McClain,
  • Dennis Warner and
  • Irina Kirpich

12 June 2020

Emerging evidence suggests that soluble epoxide hydrolase (sEH) inhibition is a valuable therapeutic strategy for the treatment of numerous diseases, including those of the liver. sEH rapidly degrades cytochrome P450-produced epoxygenated lipids (epo...

  • Article
  • Open Access
12 Citations
3,271 Views
14 Pages

Phosphoinositide Lipids in Ocular Tissues

  • Ammaji Rajala,
  • Austin McCauley,
  • Richard S. Brush,
  • Khuong Nguyen and
  • Raju V.S. Rajala

12 June 2020

Inositol phospholipids play an important role in cell physiology. The inositol head groups are reversibly phosphorylated to produce seven distinct phosphorylated inositides, commonly referred to as phosphoinositides (PIs). These seven PIs are dynamic...

  • Review
  • Open Access
97 Citations
10,759 Views
43 Pages

STAT3 Pathway in Gastric Cancer: Signaling, Therapeutic Targeting and Future Prospects

  • Milad Ashrafizadeh,
  • Ali Zarrabi,
  • Sima Orouei,
  • Vahideh Zarrin,
  • Ebrahim Rahmani Moghadam,
  • Amirhossein Zabolian,
  • Shima Mohammadi,
  • Kiavash Hushmandi,
  • Yashar Gharehaghajlou and
  • Reza Mohammadinejad
  • + 2 authors

12 June 2020

Molecular signaling pathways play a significant role in the regulation of biological mechanisms, and their abnormal expression can provide the conditions for cancer development. The signal transducer and activator of transcription 3 (STAT3) is a key...

  • Article
  • Open Access
7 Citations
4,640 Views
12 Pages

An Acromegaly Disease Zebrafish Model Reveals Decline in Body Stem Cell Number along with Signs of Premature Aging

  • Abdalla Elbialy,
  • Yoji Igarashi,
  • Shuichi Asakawa,
  • Shugo Watabe and
  • Shigeharu Kinoshita

7 June 2020

In our previous publication, it was shown that growth hormone (GH) excess in acromegaly affects the cell integrity of somatic cells through increased DNA damage throughout the body and impaired DNA repair pathways. Acromegaly is a hormone disorder pa...

  • Article
  • Open Access
2 Citations
3,815 Views
16 Pages

5 June 2020

The opener muscle in the walking legs of the crayfish (Procambarus clarkii) has three distinct phenotypic regions although innervated by only one excitatory motor neuron. These regions (distal, central, and proximal) have varied biochemistry and phys...

  • Article
  • Open Access
35 Citations
5,102 Views
21 Pages

5 June 2020

The effect of dietary omega-6 long-chain polyunsaturated fatty acid (LC-PUFA) on host microbiome and gut associated immune function in fish is unexplored. The effect of dietary supplementation with the omega-6 LC-PUFA-rich microalga Lobosphaera incis...

  • Article
  • Open Access
3 Citations
3,278 Views
9 Pages

Hydralazine Sensitizes to the Antifibrotic Effect of 5-Aza-2′-deoxycytidine in Hepatic Stellate Cells

  • Kiyoshi Asada,
  • Kosuke Kaji,
  • Shinya Sato,
  • Kenichiro Seki,
  • Naotaka Shimozato,
  • Hideto Kawaratani,
  • Hiroaki Takaya,
  • Yasuhiko Sawada,
  • Keisuke Nakanishi and
  • Hitoshi Yoshiji
  • + 6 authors

3 June 2020

Background: Hepatic stellate cell (HSC) activation is essential for the development of liver fibrosis. Epigenetic machinery, such as DNA methylation, is largely involved in the regulation of gene expression during HSC activation. Although the pharmac...

  • Article
  • Open Access
5 Citations
4,604 Views
12 Pages

Notch Inhibition via GSI Treatment Elevates Protein Synthesis in C2C12 Myotubes

  • Joshua R. Huot,
  • Joseph S. Marino,
  • Michael J. Turner and
  • Susan T. Arthur

2 June 2020

The role of Notch signaling is widely studied in skeletal muscle regeneration but little is known about its influences on muscle protein synthesis (MPS). The purpose of this study was to investigate whether Notch signaling is involved in the regulati...

  • Review
  • Open Access
84 Citations
9,729 Views
27 Pages

Saline and Arid Soils: Impact on Bacteria, Plants, and Their Interaction

  • Elisa Gamalero,
  • Elisa Bona,
  • Valeria Todeschini and
  • Guido Lingua

2 June 2020

Salinity and drought are the most important abiotic stresses hampering crop growth and yield. It has been estimated that arid areas cover between 41% and 45% of the total Earth area worldwide. At the same time, the world’s population is going t...

  • Article
  • Open Access
19 Citations
5,395 Views
25 Pages

Anti-Inflammatory and Physicochemical Characterization of the Croton rhamnifolioides Essential Oil Inclusion Complex in β-Cyclodextrin

  • Anita Oliveira Brito Pereira Bezerra Martins,
  • Almir Gonçalves Wanderley,
  • Isabel Sousa Alcântara,
  • Lindaiane Bezerra Rodrigues,
  • Francisco Rafael Alves Santana Cesário,
  • Maria Rayane Correia de Oliveira,
  • Fyama Ferreira e Castro,
  • Thaís Rodrigues de Albuquerque,
  • Maria Sanadia Alexandre da Silva and
  • Irwin Rose Alencar de Menezes
  • + 7 authors

30 May 2020

Croton rhamnifolioides is used in popular medicine for the treatment of inflammatory diseases. The objective of this study was to characterize and evaluate the anti-inflammatory effect of C. rhamnifolioides essential oil complexed in β-cyclodext...

  • Correction
  • Open Access
1 Citations
2,379 Views
2 Pages

Correction: Stalder, et al.; Value of SUVmax for the Prediction of Bone Invasion in Oral Squamous Cell Carcinoma. Biology 2020, 9, 23

  • Stephanie A. Stalder,
  • Paul Schumann,
  • Martin Lanzer,
  • Martin W. Hüllner,
  • Niels J. Rupp,
  • Martina A. Broglie and
  • Grégoire B. Morand

29 May 2020

The authors would like to make a correction to their published paper [...]

  • Article
  • Open Access
24 Citations
4,467 Views
12 Pages

Metabolomic Reprogramming Detected by 1H-NMR Spectroscopy in Human Thyroid Cancer Tissues

  • Alessio Metere,
  • Claire E. Graves,
  • Mattea Chirico,
  • Maria José Caramujo,
  • Maria Elena Pisanu and
  • Egidio Iorio

27 May 2020

Thyroid cancer cells demonstrate an increase in oxidative stress and decreased antioxidant action, but the effects of this increased oxidative stress on cell function remain unknown. We aimed to identify changes in the metabolism of thyroid cancer ce...

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Biology - ISSN 2079-7737