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Volume 12
Issue 7
10.3390/diseases12070140
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Case Report

Tumor-to-Tumor Metastasis: Dissemination of Cutaneous Squamous Cell Carcinoma Involving Parotid Warthin Tumor—Case Report

by
Michał Gontarz
1,*,
Krystyna Gałązka
2,
Krzysztof Gąsiorowski
1,
Jakub Bargiel
1,
Tomasz Marecik
1,
Paweł Szczurowski
1 and
Grażyna Wyszyńska-Pawelec
1
1
Department of Cranio-Maxillofacial Surgery, Jagiellonian University Medical College, 30-688 Cracow, Poland
2
Department of Pathology, Jagiellonian University Medical College, 30-688 Cracow, Poland
*
Author to whom correspondence should be addressed.
Diseases 2024, 12(7), 140; https://doi.org/10.3390/diseases12070140
Submission received: 3 June 2024 / Revised: 20 June 2024 / Accepted: 26 June 2024 / Published: 1 July 2024
(This article belongs to the Section Oncology)
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Abstract

Warthin tumors (WTs) are the second most common salivary gland tumors, most commonly found in the tail of the parotid gland. The lymphoid components of a WT may also serve as a site for tumor-to-tumor metastasis. This report describes the metastasis of cutaneous squamous cell carcinoma (cSCC) from the preauricular region to a parotid WT. A 68-year-old male patient was admitted to the Department of Cranio-Maxillofacial Surgery of the Jagiellonian University in Cracow, Poland, with a two-year history of a growing, painless skin tumor of the right preauricular region. The patient was eligible for surgical treatment with elective neck dissection at the Va, III, II, I levels with parotidectomy and the excision of the cSCC. In the histopathological examination of the components of the surgical specimen beside the primary cutaneous squamous cell carcinoma (cSCC), a parotid WT was found; in the majority, it was occupied and destroyed by the metastatic cSCC and radically removed. After a tumor board consultation, due to the advanced stage (pT3N2b LVI2 PNI0 R0), with three intraparotid lymph node metastases and LVI2, the patient was authorized for postoperative radiotherapy. In conclusion, tumor-to-tumor metastasis is an extremely rare entity. Surgery is the standard of care for both WTs and head and neck cSCC. In most cases, metastasis into the parotid gland can be successfully treated with superficial parotidectomy with facial nerve preservation. Dissemination into the parotid gland requires elective neck dissection, as well as adjuvant treatment.
Keywords: tumor-to-tumor metastasis; Warthin tumor; secondary tumors; cutaneous squamous cell carcinoma tumor-to-tumor metastasis; Warthin tumor; secondary tumors; cutaneous squamous cell carcinoma

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MDPI and ACS Style

Gontarz, M.; Gałązka, K.; Gąsiorowski, K.; Bargiel, J.; Marecik, T.; Szczurowski, P.; Wyszyńska-Pawelec, G. Tumor-to-Tumor Metastasis: Dissemination of Cutaneous Squamous Cell Carcinoma Involving Parotid Warthin Tumor—Case Report. Diseases 2024, 12, 140. https://doi.org/10.3390/diseases12070140

AMA Style

Gontarz M, Gałązka K, Gąsiorowski K, Bargiel J, Marecik T, Szczurowski P, Wyszyńska-Pawelec G. Tumor-to-Tumor Metastasis: Dissemination of Cutaneous Squamous Cell Carcinoma Involving Parotid Warthin Tumor—Case Report. Diseases. 2024; 12(7):140. https://doi.org/10.3390/diseases12070140

Chicago/Turabian Style

Gontarz, Michał, Krystyna Gałązka, Krzysztof Gąsiorowski, Jakub Bargiel, Tomasz Marecik, Paweł Szczurowski, and Grażyna Wyszyńska-Pawelec. 2024. "Tumor-to-Tumor Metastasis: Dissemination of Cutaneous Squamous Cell Carcinoma Involving Parotid Warthin Tumor—Case Report" Diseases 12, no. 7: 140. https://doi.org/10.3390/diseases12070140

APA Style

Gontarz, M., Gałązka, K., Gąsiorowski, K., Bargiel, J., Marecik, T., Szczurowski, P., & Wyszyńska-Pawelec, G. (2024). Tumor-to-Tumor Metastasis: Dissemination of Cutaneous Squamous Cell Carcinoma Involving Parotid Warthin Tumor—Case Report. Diseases, 12(7), 140. https://doi.org/10.3390/diseases12070140

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