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Volume 13
Issue 4
10.3390/diseases13040126
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Article

Clinical Importance of B-Type Natriuretic Peptide Levels in Sinus Rhythm at 3 Months After Persistent Atrial Fibrillation Ablation

by
Jumpei Saito
*,
Toshihiko Matsuda
,
Yui Koyanagi
,
Katsuya Yoshihiro
,
Yuma Gibo
,
Soichiro Usumoto
,
Wataru Igawa
,
Toshitaka Okabe
,
Naoei Isomura
and
Masahiko Ochiai
Division of Cardiology, Showa University Northern Yokohama Hospital, Yokohama 224-0032, Japan
*
Author to whom correspondence should be addressed.
Diseases 2025, 13(4), 126; https://doi.org/10.3390/diseases13040126 (registering DOI)
Submission received: 2 March 2025 / Revised: 17 April 2025 / Accepted: 21 April 2025 / Published: 21 April 2025
Review Reports Versions Notes

Abstract

Background: B-type natriuretic peptide (BNP) levels after ablation have been associated with a risk of arrhythmia recurrence (AR) after atrial fibrillation (AF) ablation. In addition, baseline BNP levels were also predictors of AR after AF ablation. However, previous studies have not been clear about whether sinus rhythm (SR) or AF was present at the time of BNP measurement. In this study, we investigated BNP levels in SR at 1,3 months after persistent AF ablation. Methods: We followed up 178 patients with persistent AF undergoing first-time arrhythmia ablation. BNP levels were measured before 1 and 3 months later after AF ablation in SR. The correlation between AR within 1 year after AF ablation and measured BNP levels was examined. Results: A total of 178 cases (81 males, mean age 69 (60, 74), mean CHA2DS2 Vasc score 2 (0, 4)) with persistent AF were included for ablation. BNP levels before AF ablation were not significantly different between AR and not AR patients. The BNP levels of AR patients were significantly elevated from 1 month to 3 months after the procedure compared with those without (−11.1 pg/mL (−53, 5.7) vs. 17.8 pg/mL (−58.3, 180.5), p < 0.0001). Elevated BNP levels in SR after AF ablation were a significant predictor of AR. Conclusions: Elevated BNP levels in SR 3 months after AF ablation compared with BNP levels 1 month after persistent AF ablation might be a significant prognostic factor in AR.
Keywords: arrhythmia; catheter ablation; atrial fibrillation; B-type natriuretic peptide arrhythmia; catheter ablation; atrial fibrillation; B-type natriuretic peptide

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MDPI and ACS Style

Saito, J.; Matsuda, T.; Koyanagi, Y.; Yoshihiro, K.; Gibo, Y.; Usumoto, S.; Igawa, W.; Okabe, T.; Isomura, N.; Ochiai, M. Clinical Importance of B-Type Natriuretic Peptide Levels in Sinus Rhythm at 3 Months After Persistent Atrial Fibrillation Ablation. Diseases 2025, 13, 126. https://doi.org/10.3390/diseases13040126

AMA Style

Saito J, Matsuda T, Koyanagi Y, Yoshihiro K, Gibo Y, Usumoto S, Igawa W, Okabe T, Isomura N, Ochiai M. Clinical Importance of B-Type Natriuretic Peptide Levels in Sinus Rhythm at 3 Months After Persistent Atrial Fibrillation Ablation. Diseases. 2025; 13(4):126. https://doi.org/10.3390/diseases13040126

Chicago/Turabian Style

Saito, Jumpei, Toshihiko Matsuda, Yui Koyanagi, Katsuya Yoshihiro, Yuma Gibo, Soichiro Usumoto, Wataru Igawa, Toshitaka Okabe, Naoei Isomura, and Masahiko Ochiai. 2025. "Clinical Importance of B-Type Natriuretic Peptide Levels in Sinus Rhythm at 3 Months After Persistent Atrial Fibrillation Ablation" Diseases 13, no. 4: 126. https://doi.org/10.3390/diseases13040126

APA Style

Saito, J., Matsuda, T., Koyanagi, Y., Yoshihiro, K., Gibo, Y., Usumoto, S., Igawa, W., Okabe, T., Isomura, N., & Ochiai, M. (2025). Clinical Importance of B-Type Natriuretic Peptide Levels in Sinus Rhythm at 3 Months After Persistent Atrial Fibrillation Ablation. Diseases, 13(4), 126. https://doi.org/10.3390/diseases13040126

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