Monomethylierte 3-Thiacyclopentylsulfaminsäuren und ihre Süßstoffeigenschaften

B. Unterhalt; L. Kerckhoff; M. Möllers

doi:10.3797/scipharm.aut-00-09

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Article

3 January 2000

Monomethylierte 3-Thiacyclopentylsulfaminsäuren und ihre Süßstoffeigenschaften

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Institut rur Phannazeutische Chemie der WestHilisehen Wilhelms-Universität Münster, Hittorfstr. 58-62, 0-48149 Münster, Bundesrepublik Deutschland

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Sci. Pharm.2000, 68(1), 101-108;https://doi.org/10.3797/scipharm.aut-00-09

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Abstract

Methyl-3-thiacyclopentanarnines 4a-c were reacted to their sulfamic acid sodiurn salts 5a-c, and their structures determined.Only sodium 4-methyl-3-thiacyclopentylsulfamate (5b) is sweet. The oxa analogues 8a-b however are tasteless.

Keywords:

Methyl-3-thiacyclopentanonoximes; reduction to methyl-3-thiacyclopentanamines; sodiurn methyl-3-oxa- and -3-thiacyclopentylsulfamates

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