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Volume 68
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10.3797/scipharm.aut-00-06
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Article

3D-QSAR STUDY OF NEW ACETYL-COA:CHOLESTEROL O-ACYL TRANSFERASE (ACAT) INHIBITORS †

by
Salvatore Guccione
1,*,
Filippo Russo
1 and
Thierry Langer
2
1
Dipartimento di Scienze Farmaceutiche, Universitd di Catania, viale Andrea Doria 6, Ed. 12, 1-95125 Catania, Italy
2
Institut fur Phnrmazie/Pharmazeutische Chemie, Leopold-Franzens-Universitat lnnsbruck Innrain 52a, A-6020 Innsbruck, Austria
*
Author to whom correspondence should be addressed.
†
Dedicated with best personal wishes to Prof: Dr. Wolfgang Kubelka on the occasion of his 65th anniversary
Sci. Pharm. 2000, 68(1), 65-73; https://doi.org/10.3797/scipharm.aut-00-06
Submission received: 2 February 2000 / Revised: 4 March 2000 / Accepted: 4 March 2000 / Published: 10 March 2000
Versions Notes

Abstract

3D QSAR models using comparative molecular field analysis (CoMFA) and comparative molecular similarity analysis (CoMSIA) were built on a training set of 19 previously described inhibitors of acetyl-CoA:cholesterol O-acyl transferase (ACAT) with a IC50 ranging from 47 nM to 200 µM. The models thus obtained were found to be predictive as shown by correct prediction of the inhibitory activity of a set of recently published compounds.

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MDPI and ACS Style

Guccione, S.; Russo, F.; Langer, T. 3D-QSAR STUDY OF NEW ACETYL-COA:CHOLESTEROL O-ACYL TRANSFERASE (ACAT) INHIBITORS. Sci. Pharm. 2000, 68, 65-73. https://doi.org/10.3797/scipharm.aut-00-06

AMA Style

Guccione S, Russo F, Langer T. 3D-QSAR STUDY OF NEW ACETYL-COA:CHOLESTEROL O-ACYL TRANSFERASE (ACAT) INHIBITORS. Scientia Pharmaceutica. 2000; 68(1):65-73. https://doi.org/10.3797/scipharm.aut-00-06

Chicago/Turabian Style

Guccione, Salvatore, Filippo Russo, and Thierry Langer. 2000. "3D-QSAR STUDY OF NEW ACETYL-COA:CHOLESTEROL O-ACYL TRANSFERASE (ACAT) INHIBITORS" Scientia Pharmaceutica 68, no. 1: 65-73. https://doi.org/10.3797/scipharm.aut-00-06

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