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Volume 68
Issue 1
10.3797/scipharm.aut-00-07
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Article

Zur Synthese von ionenkanalblockierenden Substanzen mit Thieno[2,3-b][1,4]thiazin-, 1,4-Benzoxazin und 1,4-Benzothiazin-Grundgerüst

by
M. E. Schreder
and
T. Erker
*,$
Institut für Pharmazeutische Chemie der Universität Wien, Althanstraße 14, A-1090 Wien, Österreich
*
Author to whom correspondence should be addressed.
$
Herrn o. Univ.-Prof. Dr. W. Kubelka mit den besten Wünschen zum 65. Geburtstag gewidmet
Sci. Pharm. 2000, 68(1), 75-85; https://doi.org/10.3797/scipharm.aut-00-07
Submission received: 31 January 2000 / Revised: 3 March 2000 / Accepted: 3 March 2000 / Published: 10 March 2000
Versions Notes

Abstract

The syntheses of the thieno[2,3-b)[1,4]thiazine derivatives 8 and 9 are described. Reaction of compound 4 with different acyl halides followed by substitution with various ethanamines gave the products 8 and 9. The new 3,4-dihydro-2H-1,4-benzoxazine derivatives 14, 16, 18 and 3,4-dihydro-2H-1,4-benzothiazine derivatives 15 and 17 with an urea moiety have been synthesized. Substitution of 10 respectively 11 with 4-nitrophenyl chloroformate gave the required reactivity for substitution with diamines. Structural modifications of the amino side chain were carried out.
Keywords: Thieno[2,3-b][1, 4]thiazines; 1,4-Benzoxazines; 1,4-Benzothiazines; Ion Channel Antagonistic Activity Thieno[2,3-b][1, 4]thiazines; 1,4-Benzoxazines; 1,4-Benzothiazines; Ion Channel Antagonistic Activity

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MDPI and ACS Style

Schreder, M.E.; Erker, T. Zur Synthese von ionenkanalblockierenden Substanzen mit Thieno[2,3-b][1,4]thiazin-, 1,4-Benzoxazin und 1,4-Benzothiazin-Grundgerüst. Sci. Pharm. 2000, 68, 75-85. https://doi.org/10.3797/scipharm.aut-00-07

AMA Style

Schreder ME, Erker T. Zur Synthese von ionenkanalblockierenden Substanzen mit Thieno[2,3-b][1,4]thiazin-, 1,4-Benzoxazin und 1,4-Benzothiazin-Grundgerüst. Scientia Pharmaceutica. 2000; 68(1):75-85. https://doi.org/10.3797/scipharm.aut-00-07

Chicago/Turabian Style

Schreder, M. E., and T. Erker. 2000. "Zur Synthese von ionenkanalblockierenden Substanzen mit Thieno[2,3-b][1,4]thiazin-, 1,4-Benzoxazin und 1,4-Benzothiazin-Grundgerüst" Scientia Pharmaceutica 68, no. 1: 75-85. https://doi.org/10.3797/scipharm.aut-00-07

APA Style

Schreder, M. E., & Erker, T. (2000). Zur Synthese von ionenkanalblockierenden Substanzen mit Thieno[2,3-b][1,4]thiazin-, 1,4-Benzoxazin und 1,4-Benzothiazin-Grundgerüst. Scientia Pharmaceutica, 68(1), 75-85. https://doi.org/10.3797/scipharm.aut-00-07

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