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Sci. Pharm.
Volume 70
Issue 1
10.3797/scipharm.aut-02-06
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Article

New Application of Chromotropic Acid for the Determination of Some Sulphonamides in their Pharmaceutical Preparations

by
Abou-Attia Fekria M.
1,*,
Issa Y.M.
2,
El Reis M.A.
1,
Aly F.A.
3 and
Abd El- MoetY M.
1
1
NationaOl rganization for Drug Control and Research P.O. Box 29 Cairo, Egypt
2
Facultoyf Science, Cairo University, Giza, Egypt
3
Facultoyf Science, Menoufia University, Shebin El-Kom, Egypt
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2002, 70(1), 49-55; https://doi.org/10.3797/scipharm.aut-02-06
Submission received: 22 January 2001 / Revised: 15 November 2001 / Accepted: 15 November 2001 / Published: 25 January 2002
Versions Notes

Abstract

The formation of the azo-dye using chromotropic acid as a coupling agent was applied to the determination of five sulphonamides. The spectrophotometric studies as well as microanalysis of the studied sulphonamides- chromotropic acid azo dyes revealed the existence of the 1:1 coupling product. The absorbance of the formed azo dye is measured at 510 nrn, and has a large molar absorptivity (ε = 2.87 - 3.29 × 104 1 mol−1cm−1). Beer's law was obeyed over the concentration range 0.5-9.0 µg ml−1. The assay results of pharmaceutical formulations showed good accuracy and precision over the concentration range used. The proposed method avoids time-consumption, extraction process and temperature control.
Keywords: Sulphonamides; Chromotropic acid; Azo dyes; Spectrophotometry Sulphonamides; Chromotropic acid; Azo dyes; Spectrophotometry

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MDPI and ACS Style

Fekria M., A.-A.; Y.M., I.; M.A., E.R.; F.A., A.; M., A.E.- M. New Application of Chromotropic Acid for the Determination of Some Sulphonamides in their Pharmaceutical Preparations. Sci. Pharm. 2002, 70, 49-55. https://doi.org/10.3797/scipharm.aut-02-06

AMA Style

Fekria M. A-A, Y.M. I, M.A. ER, F.A. A, M. AE-M. New Application of Chromotropic Acid for the Determination of Some Sulphonamides in their Pharmaceutical Preparations. Scientia Pharmaceutica. 2002; 70(1):49-55. https://doi.org/10.3797/scipharm.aut-02-06

Chicago/Turabian Style

Fekria M., Abou-Attia, Issa Y.M., El Reis M.A., Aly F.A., and Abd El- MoetY M. 2002. "New Application of Chromotropic Acid for the Determination of Some Sulphonamides in their Pharmaceutical Preparations" Scientia Pharmaceutica 70, no. 1: 49-55. https://doi.org/10.3797/scipharm.aut-02-06

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