Scientia Pharmaceutica

2332 KiB

Open AccessArticle

Phenylpropanoids and Polyacetylenes from Ligusticum mutellina (Apiaceae) of Tyrolean Origin

by Spitaler Renate, Ellmerer-Müller Ernst-Peter, Zidorn Christian and Stuppner Hermann

Sci. Pharm. 2002, 70(1), 101-109; https://doi.org/10.3797/scipharm.aut-02-12 - 25 Mar 2002

Cited by 7 | Viewed by 1245

Roots of Ligusticum mutellina (L.) CRANTZ afforded five major compounds, the phenylpropanoids trans-isoelemicin (1), sarisan (2), and trans-isomyristicin (3), and the polyacetylenes falcarindiol (4) and falcarindiol-3-O-acetate (5). Structures were assigned by 1D- and [...] Read more.

Roots of Ligusticum mutellina (L.) CRANTZ afforded five major compounds, the phenylpropanoids trans-isoelemicin (1), sarisan (2), and trans-isomyristicin (3), and the polyacetylenes falcarindiol (4) and falcarindiol-3-O-acetate (5). Structures were assigned by 1D- and 2D-NMR spectroscopy. Close inspection of the NMR spectra of falcarindiol-3-O-acetate (5) and comparison with the literature revealed that published NMR data for this compound are most probably attributable to cis or trans Δ2-isofalcarindiol-1-O-acetate (6a/6b). ¹H and ¹³C NMR data for falcarindiol-3-O-acetate are given and trans-isoelemicin (1), sarisan (2), and trans-isomyristicin (3), falcarindiol (4), and falcarindiol-3-O-acetate (5) are reported for the first time from Ligusticum mutellina. Chemosystematic and ethnopharmacological implications of the findings are discussed briefly. Full article

2176 KiB

Open AccessArticle

Chemical composition and antibacterial activities of the essential oils of Plectranthus glandulosus and Cinnumomum zeylrrnicum from Cameroon

by Jirovetz Leopold, Buchbauer Gerhard, Ngassoum Martin B., Essia-Ngang Jean J., Tatsadjieu Leopold N. and Adjoudji Ousman

Sci. Pharm. 2002, 70(1), 93-99; https://doi.org/10.3797/scipharm.aut-02-11 - 18 Mar 2002

Cited by 14 | Viewed by 1214

Abstract

Two aromatic plants have been selected for chemical investigation on account of their antibacterial activities, Plectranthus glandulosus (fresh leaves) and Cinnamomum zeylunicum (dried leaves). P. glandulosus is used as a medicinal plant, while Cinnamomum zeylunicum is used as a common spice in many [...] Read more.

Two aromatic plants have been selected for chemical investigation on account of their antibacterial activities, Plectranthus glandulosus (fresh leaves) and Cinnamomum zeylunicum (dried leaves). P. glandulosus is used as a medicinal plant, while Cinnamomum zeylunicum is used as a common spice in many recipes in Cameroon. The essential oils of the plants have been obtained by hydrodistillation using a Clevenger type apparatus, the yields of oils are about 0.3% and 2.0% respectively.The essential oil of P. glandulosus contains mainly β-thujone (about 31%), p-cymen-8-01 (about 25%) and neral (about 10%) and the essential oil of C. zcylcinicum is characterised by a high percentage of eugenol (85%).These essential oils have been tested against three strains of bacteria, namely Pseudornonas fluorescens. Escherichiu coli and Staphylococcus aureus; qualitative tests (diffusion through solid medium) and quantitative tests (dilution method) have been carried out. P. fluorescens shows a higher resistance to the two oils (MIC values not less than 5000 ppm). E. coli is more sensitive to these oils, while against S uureus the essential oil of C. zcylcinicum still shows a high activity (3500 ppm).The antibacterial activities of the essential oils could be attributed to the components eugenol as the active component of C. zcylcinicum and β-thujone and p-cymen-4-01 of the essential oil of P. glandulosus. Full article

2127 KiB

Open AccessArticle

The influence of the isolation method on the composition of the essential oil of leaves and twigs of Juniperus communis L. var. saxatilis Pall. growing in Norway

by Karlsen Jan and Svendsen A. Baerheim

Sci. Pharm. 2002, 70(1), 87-92; https://doi.org/10.3797/scipharm.aut-02-10 - 5 Mar 2002

Cited by 7 | Viewed by 1068

Abstract

Studies on the essential oil of leaves and terminal twigs of Juniperus communis L. var. saxatilis Pall., isolated by steam and hydro distillation using Clevenger type apparatuses showed marked differences in the composition depending on whether the plant material was either comminuted or [...] Read more.

Studies on the essential oil of leaves and terminal twigs of Juniperus communis L. var. saxatilis Pall., isolated by steam and hydro distillation using Clevenger type apparatuses showed marked differences in the composition depending on whether the plant material was either comminuted or not prior to the distillation, as well as depending upon the duration of the distillation connected herewith. Full article

2822 KiB

Open AccessArticle

Preparation and evaluation of tolmetin sodium conventional and sustained-release suppositories

by Baloǧlu B. and Kirkaǧaçhoǧlu O.

Sci. Pharm. 2002, 70(1), 77-86; https://doi.org/10.3797/scipharm.aut-02-09 - 14 Feb 2002

Viewed by 1128

Abstract

Conventional suppositories of tolmetin sodium were prepared by using two different types of Witepsol as an oily base and two different ratios of polyethylene glycol 400: polyethylene glycol 4000 as an water-soluble base. In addition, sustained- release suppositories were prepared by adding Eudragit [...] Read more.

Conventional suppositories of tolmetin sodium were prepared by using two different types of Witepsol as an oily base and two different ratios of polyethylene glycol 400: polyethylene glycol 4000 as an water-soluble base. In addition, sustained- release suppositories were prepared by adding Eudragit L-100 ta the suppositories. The effects of the suppository base and the ratios of the polyethylene glycol 400: polyethylene glycols 4000 on the in vitro release characteristics were investigated. The release rate of tolmetin sodium from the conventional suppositories prepared with polyethylene glycol was slower than the other suppositories prepared with Witepsol. All of the suppositories with Eudragit L-100 showed slow-release profiles and the drug release rates clearly depended on the Eudragit L-100 content. When dissolution results were evaluated kinetically, zero order kinetic was observed with the sustained- release suppositories of tolmetin sodium prepared with polyethyleneglycol 400: polyethyleneglycol 4000 by adding Eudragit L-100. Full article

3901 KiB

Open AccessArticle

SPECTROMETRIC INVESTIGATION OF CEFPROZIL IN BULK POWDER AND IN PHARMACEUTICAL FORMULATIONS

by EI-Adl Sobhy M. and Saleh Hanaa M.

Sci. Pharm. 2002, 70(1), 67-76; https://doi.org/10.3797/scipharm.aut-02-08 - 4 Feb 2002

Cited by 4 | Viewed by 1092

Abstract

Three accurate methods were developed for the quantitative determination of cefprozil in pure form and in its dosage forms. The first method was based upon the interaction of the drug with 3-methyl-benzothiazolinone-2-hydrazone (MBTH) in the presence of ceric ammonium sulfate or ferric chloride [...] Read more.

Three accurate methods were developed for the quantitative determination of cefprozil in pure form and in its dosage forms. The first method was based upon the interaction of the drug with 3-methyl-benzothiazolinone-2-hydrazone (MBTH) in the presence of ceric ammonium sulfate or ferric chloride as an oxidizing agent, where the formed color was measured at λ 521 nm or 624 nm, respectively. The second inethod was based on the chelate formation with palladium (II) chloride (PdCl₂) in the presence of buffered medium, where the formed complex was determined at λ 345 nm. The third method was based upon the reaction of the neutral solution of the hydrolysis product of drug with each of silver nitrate & lead acetate standard solutions, forming drug-metal complex and the metal ion contents were determined directly or indirectly by atomic absorption spectroscopy (AAS). The reaction conditions of the proposed methods were studied and optimized. The precision of the proposed methods was achieved by determining different samples of bulk powder and pharmaceutical dosage forms. The validity of the methods was assessed by applying the standard addition technique and the results were compared with those obtained by the reference method showing a great agreement Full article

3189 KiB

Open AccessArticle

A New Sensitive Fluorirnetric Method for the Determination of Heptaminol and Mexiletine in Pharmaceuticals

by EI-Adl Sobhy M.

Sci. Pharm. 2002, 70(1), 57-65; https://doi.org/10.3797/scipharm.aut-02-07 - 1 Feb 2002

Cited by 3 | Viewed by 998

Abstract

An accurate and very sensitive spectrofluorimetric method is proposed for the estimation of heptaminol (HP) and mexiletine (MX) in their pure forms and in pharlnaceutical formulations. The method is based on the reaction of these drugs with the strong fluorigenic reagent [9,1O-Dimethoxy-2-anthracenesulfonic acid [...] Read more.

An accurate and very sensitive spectrofluorimetric method is proposed for the estimation of heptaminol (HP) and mexiletine (MX) in their pure forms and in pharlnaceutical formulations. The method is based on the reaction of these drugs with the strong fluorigenic reagent [9,1O-Dimethoxy-2-anthracenesulfonic acid sodium salt (DAS)] at pH (2.5). The formed complexes are extracted into chloroform and measured spectrofluori~netrically. The maximum wavelengths of excitation and emission spectra of heptaminol complex are 381 and 441 m, respectively. While those of mexiletine complex are 385 and 450 nrn, respectively. Heptaminol can be determined in the concentration range of 0.016-0.144 µg ml⁻¹ and that of mexiletine in the range of 0.024-0.176 µg ml⁻¹, when extracted from the solutions into chloroform. Different parameters affecting the reaction conditions were thoroughly studied. No interference was observed in the presence of common pharmaceutical excipients. The proposed method has been successfully applied to the analysis of commercial pharmaceutical fonnulations and the results have been statistically compared with those obtained by the reference methods. Full article

2128 KiB

Open AccessArticle

New Application of Chromotropic Acid for the Determination of Some Sulphonamides in their Pharmaceutical Preparations

by Abou-Attia Fekria M., Issa Y.M., El Reis M.A., Aly F.A. and Abd El- MoetY M.

Sci. Pharm. 2002, 70(1), 49-55; https://doi.org/10.3797/scipharm.aut-02-06 - 25 Jan 2002

Cited by 2 | Viewed by 993

Abstract

The formation of the azo-dye using chromotropic acid as a coupling agent was applied to the determination of five sulphonamides. The spectrophotometric studies as well as microanalysis of the studied sulphonamides- chromotropic acid azo dyes revealed the existence of the 1:1 coupling product. [...] Read more.

The formation of the azo-dye using chromotropic acid as a coupling agent was applied to the determination of five sulphonamides. The spectrophotometric studies as well as microanalysis of the studied sulphonamides- chromotropic acid azo dyes revealed the existence of the 1:1 coupling product. The absorbance of the formed azo dye is measured at 510 nrn, and has a large molar absorptivity (ε = 2.87 - 3.29 × 10⁴ 1 mol⁻¹cm⁻¹). Beer's law was obeyed over the concentration range 0.5-9.0 µg ml⁻¹. The assay results of pharmaceutical formulations showed good accuracy and precision over the concentration range used. The proposed method avoids time-consumption, extraction process and temperature control. Full article

2645 KiB

Open AccessArticle

Syrltllesis and Alltituberculous activity of N-Mannich bases of 3-[4-(4 chloropheny1)-6-(4-methylphesyl) pyrimidin-2-yl] iminoisatin derivatives

by Sriram D., Yogeeswari P., Pandeya S.N. and Ananthan S.

Sci. Pharm. 2002, 70(1), 39-48; https://doi.org/10.3797/scipharm.aut-02-05 - 21 Jan 2002

Cited by 6 | Viewed by 934

Abstract

Tuberculosis is making a worldwide resurgence [...] Full article

2779 KiB

Open AccessArticle

Influence of aminoacid anions on the absorption process of Mg²⁺ ions in vitro

by Marcoin W. and Szulc B.

Sci. Pharm. 2002, 70(1), 29-37; https://doi.org/10.3797/scipharm.aut-02-04 - 14 Jan 2002

Cited by 7 | Viewed by 904

Abstract

Influence of aminoacid anions on the absorption process of Mg²⁺ ions in vitro - The results of the research on influence of modification in the structure of magnesium salts with glycine on the process of Mg (11) ions absorption were presented in [...] Read more.

Influence of aminoacid anions on the absorption process of Mg²⁺ ions in vitro - The results of the research on influence of modification in the structure of magnesium salts with glycine on the process of Mg (11) ions absorption were presented in this paper. A flow-through apparatus containing a piece of small intestine of a rat was used for the absorption rate measurement of selected organic magnesium salts. The results of the investigations showed the positive influence of modification of the structure on the absorption process. A correlation was established between quantity of absorbed magnesium and the partition coefficient values (log P). Full article

1627 KiB

Open AccessArticle

Substituierte I-Isochromenyl-essigsäureethylester, verbrückte Stilbene

by Unterhalt B. and Fahrig M.

Sci. Pharm. 2002, 70(1), 25-28; https://doi.org/10.3797/scipharm.aut-02-03 - 10 Jan 2002

Viewed by 939

Abstract

Substituted ethyl 1-methyl-3-phenyl-1-isochromenyl-acetates 4-6 are synthesized by reacting the earbonitriles 1-3 with Reformatzky reagent [...] Full article

1877 KiB

Open AccessArticle

Haltbarkeit von Arzneimitteln nach Anbruch: Von der Marktüberwachungsstudie zur EU-Guideline

by Edlinger I., Liebenberger I., Macas R., Mayrhofer A., Stouer S. and Wirthumer-Hoche C.

Sci. Pharm. 2002, 70(1), 15-24; https://doi.org/10.3797/scipharm.aut-02-02 - 10 Jan 2002

Viewed by 1179

Abstract

The in-use stability of 25 drug products (oralliquids) with sensitive active ingredients was tested with a new test design simulating the stress of practical use. The results showed in so me cases a dramatic degradation of the active ingredient and the need of [...] Read more.

The in-use stability of 25 drug products (oralliquids) with sensitive active ingredients was tested with a new test design simulating the stress of practical use. The results showed in so me cases a dramatic degradation of the active ingredient and the need of a reduced shelf life after first opening. Therefore the topic "in-use stability testing of human medicinal products" was brought forward to the QWP of the CPMP^cby a member of the BlfA. Austria was appointed as rapporteur for the elaboration of the corresponding guideline. Full article

4093 KiB

Open AccessArticle

Die Benzidinblau-Reaktion in der pharmazeutischen Analytik

by Kallmayer H.-J. and Trojan B.

Sci. Pharm. 2002, 70(1), 1-14; https://doi.org/10.3797/scipharm.aut-02-01 - 9 Jan 2002

Cited by 2 | Viewed by 969

Abstract

Vor mehr als 150 Jahren hat Zinin das unsubstituierte Benzidin (1) synthetisiert und dessen Blaufärbung mit oxidierenden Reagentien beobachtet [1] [...] Full article

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Sci. Pharm., Volume 70, Issue 1 (March 2002) – 12 articles , Pages 1-109

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