Synthesis of new piperidine and cyclohexylamino-spiro derivatives as potential anticalcium agents
by
Sánchez Isabel
1,
Pujol Maria Dolors
1,*, 
Guillaumet Gérald
2,
Massingham Roy
3 and
Monteil André
4 1
Laboratori de Quimica Farmaceutica, Facultat de Farmacia, Universitat de Barcelona, Av. Diagonal 643, 08028 Barcelona (Spain)
2
lnstitut de Chimie Organique et Analytique associe au CNRS, Universite d'orleans, BP 6957,45067 Orleans Cedex 2 (France).
3
UCB Pharma, Pharmaceutical Sector, Chemin du Foriest, B-1420 Braine-L'Alleud (Belgique)
4
Laboratoire RL-CERM, ZI La Varenne, rue H. Goudier, 63203 Riom, Cedex (France)
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2002, 70(2), 177-185; https://doi.org/10.3797/scipharm.aut-02-19
Submission received: 11 February 2002
/
Revised: 4 March 2002
/
Accepted: 4 March 2002
/
Published: 4 June 2002
Simple Summary
The synthesis of new 1,3-benzodioxolo and 1,4- benzodioxan spiro derivatives containing a piperidine (4-6) or cyclohexylamino (7-8) group have been described. These compounds exhibit in vitro a moderate anticalcium activity.
Excerpt
Note: In lieu of an abstract, this is an excerpt from the first page.
The spiropiperidine derivatives have considerable importance in pharmaceutical chemistry due to their effects on different biological systems [...]
