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Sci. Pharm.
Volume 70
Issue 2
10.3797/scipharm.aut-02-20
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Article

Investigation of certain varieties of carbopol in ketorolac tromethamine hydrophilic matrix tablet formulations and evaluation of the kinetics of its in vitm release

by
Genç Lütfi
1,*,
Hegazy Nahed
1 and
Arica Betül
2
1
Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Technology, 26470 Eskigehir, Turkey
2
Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Technology, 061 00 Ankara, Turkey
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2002, 70(2), 189-198; https://doi.org/10.3797/scipharm.aut-02-20
Submission received: 15 January 2001 / Revised: 28 February 2002 / Accepted: 28 February 2002 / Published: 10 June 2002
Versions Notes

Abstract

Matrix tablets of ketorolac trometharnine (KT) were prepared by direct compression technique and Carbopol 934, 940 and 1342 have been used as polymers in different concentrations (5-15 % ). For the quality control of tablets; physical tests as crushing strength, diameter-height ratio and fkiability, KT amount assay and in vitro dissolution techniques were performed and dissolution profiles were plotted and evaluated kinetically. The in vitro release kinetics of ten different formulations of KT matrix tablet were studied at pH 1.2 and pH 7.0 using the USP dissolution technique and apparatus with basket assembly. Dissolution results were evaluated kinetically and statistically. According to our results, different types and concentrations of carbopol to tablet formulations may effect in controlled drug release.
Keywords: Hydrophilic matrix tablet, Carbopol, Ketorolac tromethamine, In vitro release kinetics, Sustained release Hydrophilic matrix tablet, Carbopol, Ketorolac tromethamine, In vitro release kinetics, Sustained release

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MDPI and ACS Style

Lütfi, G.; Nahed, H.; Betül, A. Investigation of certain varieties of carbopol in ketorolac tromethamine hydrophilic matrix tablet formulations and evaluation of the kinetics of its in vitm release. Sci. Pharm. 2002, 70, 189-198. https://doi.org/10.3797/scipharm.aut-02-20

AMA Style

Lütfi G, Nahed H, Betül A. Investigation of certain varieties of carbopol in ketorolac tromethamine hydrophilic matrix tablet formulations and evaluation of the kinetics of its in vitm release. Scientia Pharmaceutica. 2002; 70(2):189-198. https://doi.org/10.3797/scipharm.aut-02-20

Chicago/Turabian Style

Lütfi, Genç, Hegazy Nahed, and Arica Betül. 2002. "Investigation of certain varieties of carbopol in ketorolac tromethamine hydrophilic matrix tablet formulations and evaluation of the kinetics of its in vitm release" Scientia Pharmaceutica 70, no. 2: 189-198. https://doi.org/10.3797/scipharm.aut-02-20

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