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Sci. Pharm.
Volume 75
Issue 4
10.3797/scipharm.2007.75.171
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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Article

Stability Evaluation of Methylparaben and Propylparaben in their Solution Aqua Conservans Using HPLC

by
Jan Šubert
,
Oldřich Fars
* and
Marie Marečková
nstitute of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, 612 42 Brno, Czech Republic
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2007, 75(4), 171-178; https://doi.org/10.3797/scipharm.2007.75.171
Submission received: 30 August 2007 / Accepted: 5 December 2007 / Published: 31 December 2007
Versions Notes

Abstract

HPLC was used to determine the content of methylparaben (MP), propylparaben (PP) and 4-hydroxybenzoic acid (4-HYB) as their decomposition product in the water solution Aqua Conservans (AQCO) in accordance with the Czech Pharmacopoeia and the Slovak Pharmaceutical Codex (0.067 % MP and 0.033 % PP). Based on the results of the analyses of 10 samples of AQCO from 8 pharmacies, 4-42 months after their preparation, an expiration period of 3 years was proposed for AQCO.
Keywords: Parabens; Aqua Conservans; stability; 4-hydroxybenzoic acid; HPLC Parabens; Aqua Conservans; stability; 4-hydroxybenzoic acid; HPLC

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MDPI and ACS Style

Šubert, J.; Fars, O.; Marečková, M. Stability Evaluation of Methylparaben and Propylparaben in their Solution Aqua Conservans Using HPLC. Sci. Pharm. 2007, 75, 171-178. https://doi.org/10.3797/scipharm.2007.75.171

AMA Style

Šubert J, Fars O, Marečková M. Stability Evaluation of Methylparaben and Propylparaben in their Solution Aqua Conservans Using HPLC. Scientia Pharmaceutica. 2007; 75(4):171-178. https://doi.org/10.3797/scipharm.2007.75.171

Chicago/Turabian Style

Šubert, Jan, Oldřich Fars, and Marie Marečková. 2007. "Stability Evaluation of Methylparaben and Propylparaben in their Solution Aqua Conservans Using HPLC" Scientia Pharmaceutica 75, no. 4: 171-178. https://doi.org/10.3797/scipharm.2007.75.171

APA Style

Šubert, J., Fars, O., & Marečková, M. (2007). Stability Evaluation of Methylparaben and Propylparaben in their Solution Aqua Conservans Using HPLC. Scientia Pharmaceutica, 75(4), 171-178. https://doi.org/10.3797/scipharm.2007.75.171

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