Scientia Pharmaceutica, Volume 76, Issue 4

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This study presents the actions of risperidone (Risp) and haloperidol (Hal) on the behavioral effects elicited by ketamine (Ket) on open-field (OF), rota rod (RR) and tail suspension (TS) tests in mice. Male Swiss albino mice (25–30g) were used. Anti...

In contrast to the huge variety of sesquiterpene lactones reported, only a limited number of flavonoids and phenolic acids are known from the genus Crepis. Compounds detected in the course of this investigation encompass flavonoids luteolin, luteolin...

The blood-brain barrier (BBB) is a formidable obstacle for the delivery of therapeutic agents into the central nervous system. Hydroxysafflor yellow A (HSYA) has been shown to be effective in protecting cerebral ischemia. However, whether HSYA could...

Cilostazol is a potent phosphodiesterase inhibitor; its major effects are prevention of platelet aggregation and dilation of blood vessels via an increase in tissue cAMP levels. This study examined the effect of cilostazol on serum cAMP, type 1 plasm...

The purpose of present study was to prepare and characterize the complex between curcumin and soya lecithin, and to evaluate its hepatoprotective activity. The curcumin-soya lecithin complex was prepared by dissolving curcumin and soya lecithin in eq...

The first total synthesis of ergosta-5,8-dien-3β-ol, an uncommon sterol previously isolated from an alga and several microorganisms, has been developed. For the first time, a full set of spectroscopic data of this sterol is presented.

Objective: In this study, the effects of baicalin – a flavonoid purified from Scutellaria baicalensis. Georgi, Scutellaria L. – on alveolar bone resorption in rat experimental periodontitis were examined. Method: 12 Sprague-Dawley rats (SD rats) were...

The cyclodextrins have a wide range of applications in different areas of drug delivery and pharmaceutical industry due to their complexation ability and other versatile characteristics. The most common pharmaceutical application of cyclodextrin is t...

Chemokines receptors have emerged as important drug targets for development of agents against the HIV/AIDS pandemic. With the purpose of designing new chemical entities with enhanced antagonistic potencies against the CCR5 chemokine receptor, the QSA...

This double blind randomised trial compared the clinical efficacy of Femineral^®, a proprietary herbal preparation containing highly soluble iron compounds, minerals, and vitamins, with Floradix^®, the most popular iron supplement in Scandinavia for pa...

The aim of this work was the chemical modification of pectins by limited acetylation of their free hydroxyl groups to yield high ester pectins and to investigate its swelling and erosion behavior along with the effect on the release pattern of drugs....

A new high-throughput liquid chromatographic tandem mass spectrometric (LC-MS/MS) assay for the quantification of valproic acid in human plasma was developed and validated. The separation was performed on a Zorbax SB-C18 column under isocratic condit...

Two unknown impurities were detected in stressed samples (by hydrochloric acid and hydrogen peroxide) of paroxetine hydrochloride hemihydrate (an active pharmaceutical ingredient – API) using a gradient reversed-phase high performance liquid chromato...

The efficacy of polyion-complexes between charged liposomes and oppositely charged polymers for the oral delivery of therapeutic peptides and proteins has been reported previously. It was the aim of the current study, to investigate whether polyion-c...

A series of N-methyl/acetyl 5-(un)-substituted isatin-3-semicarbazones were screened for anticonvulsant and sedative-hypnotic activities. The results revealed that protection was obtained in all the screens i.e., Maximal electroshock, (MES) subcutane...

[⁶¹Cu]-N-(2-hydroxyacetophenone)glycinate ([⁶¹Cu]NHAG) was prepared using in house-made NHAG ligand and [⁶¹Cu]CuCl2 produced via the ^natZn(p,x)⁶¹Cu (180μA proton irradiation, 22MeV, 3.2h) and purified by a ion chromatography method. [⁶¹Cu]NHAG radioc...