Next Article in Journal
Transport of NSAIDs across the Blood-Brain Barrier in vitro
Previous Article in Journal
Functionability of NMDA-Receptors in an in vitro model of the Blood-Brain-Barrier
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Sci. Pharm.
Volume 77
Issue 7
10.3797/scipharm.oephg.21.PO-20
scipharm-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Abstract

Functionality of P-glycoprotein in the Blood-Brain Barrier Mimicking Cell Line PBMEC/C1-2

by
W. NEUHAUS
1,
M. STESSL
2,
E. STRIZSIK
2,
B. BENNANI-BAITI
2,
M. WIRTH
3,
J. MANDIKOVA
2,
R. PAWLOWITSCH
2,
S. TÖGEL
3,
J. WINKLER
2,
F. GABOR
3 and
C. R. NOE
2,*
1
PharmaCon GmbH, Riglergasse 4/5, 1180 Vienna, Austria
2
Department of Medicinal Chemistry, University of Vienna, Althanstraße 14, 1090 Vienna, Austria
3
Department of Pharmaceutical Technology and Biopharmaceutics, University of Vienna, Althanstraße 14, 1090 Vienna, Austria
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2009, 77(7), 219; https://doi.org/10.3797/scipharm.oephg.21.PO-20
Submission received: 16 April 2009 / Accepted: 16 April 2009 / Published: 16 April 2009
Versions Notes

Abstract

The blood-brain barrier (BBB) maintains the homeostasis between the central nervous system and the blood circulation [1]. One of the main efflux transporter proteins at the BBB is P-glycoprotein (P-gP) also known as ABCB1 or MDR1. Recently, transport studies with antidepressants suggested presence and functional activity of P-gP in an in vitro model of the BBB based on porcine cell line PBMEC/C1-2 [2]. Due to the important role of P-gP for the transport barrier function of the BBB, the presence and functionability of P-gP was investigated in cell line PBMEC/C1-2 maybe leading to an in vitro BBB model suitable for P-gP substrate screening.

Share and Cite

MDPI and ACS Style

NEUHAUS, W.; STESSL, M.; STRIZSIK, E.; BENNANI-BAITI, B.; WIRTH, M.; MANDIKOVA, J.; PAWLOWITSCH, R.; TÖGEL, S.; WINKLER, J.; GABOR, F.; et al. Functionality of P-glycoprotein in the Blood-Brain Barrier Mimicking Cell Line PBMEC/C1-2. Sci. Pharm. 2009, 77, 219. https://doi.org/10.3797/scipharm.oephg.21.PO-20

AMA Style

NEUHAUS W, STESSL M, STRIZSIK E, BENNANI-BAITI B, WIRTH M, MANDIKOVA J, PAWLOWITSCH R, TÖGEL S, WINKLER J, GABOR F, et al. Functionality of P-glycoprotein in the Blood-Brain Barrier Mimicking Cell Line PBMEC/C1-2. Scientia Pharmaceutica. 2009; 77(Posters (PO)):219. https://doi.org/10.3797/scipharm.oephg.21.PO-20

Chicago/Turabian Style

NEUHAUS, W., M. STESSL, E. STRIZSIK, B. BENNANI-BAITI, M. WIRTH, J. MANDIKOVA, R. PAWLOWITSCH, S. TÖGEL, J. WINKLER, F. GABOR, and et al. 2009. "Functionality of P-glycoprotein in the Blood-Brain Barrier Mimicking Cell Line PBMEC/C1-2" Scientia Pharmaceutica 77, Posters (PO): 219. https://doi.org/10.3797/scipharm.oephg.21.PO-20

Article Metrics

Back to TopTop