Transport of NSAIDs across the Blood-Brain Barrier in vitro

I. NOVAKOVA; W. NEUHAUS; M. SONNENBERG; C. R. NOE

doi:10.3797/scipharm.oephg.21.PO-21

You are currently on the new version of our website. Access the old version .

Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).

Abstract

16 April 2009

Transport of NSAIDs across the Blood-Brain Barrier in vitro

and

Department of Medicinal Chemistry, University of Vienna, Pharmacy Center, Althanstraße 14, 1090 Vienna, Austria

PharmaCon GmbH, Riglergasse 4/5, 1180, Vienna, Austria

Author to whom correspondence should be addressed.

Sci. Pharm.2009, 77(7), 220;https://doi.org/10.3797/scipharm.oephg.21.PO-21

Version Notes

Order Reprints

Abstract

The migration of substances between blood circulation and central nervous system (CNS) is regulated by the blood-brain barrier (BBB). Small lipophilic molecules such as carbon dioxide, oxygen or ethanol can pass the BBB by passive, transcellular diffusion, while the paracellular transport of hydrophilic substances is restricted by intercellular tight-junctions. Due to accessory transport systems the BBB is able to regulate specifically the permeation of substances (e.g. nutrients) [1].

Article Metrics

Citations

Article Access Statistics

Journal Statistics

Multiple requests from the same IP address are counted as one view.

Functionality of P-glycoprotein in the Blood-Brain Barrier Mimicking Cell Line PBMEC/C1-2

Pharmacological Profile of Novel Dithiodibenzamides