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Sci. Pharm.Scientia Pharmaceutica
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  • Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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16 April 2009

Honokiol Modulates GABAA Receptors Subunit Specifically

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1
Department of Pharmacology, University of Vienna, Althanstr. 14, 1190 Wien, Österreich
2
Institute of Pharmaceutical Biology, University of Basel, Klingelbergstraße 50, 4056, Basel, Switzerland
3
Department of Pharmacognosy, University of Graz, Universitätsplatz 4, 8010 Graz, Austria
*
Author to whom correspondence should be addressed.
Sci. Pharm.2009, 77(7), 225;https://doi.org/10.3797/scipharm.oephg.21.PO-26
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Honokiol, a neolignan compound isolated from Magnolia species has been suggested to interact with GABAA receptors. Evidence comes from honokiol-induced enhanced [3H]muscimol binding [1] and anxiolytic action in behavioural studies [2]. The molecular mechanism and possible subunit-specific effects of honokiol on GABAA receptors are currently unknown.[...]

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