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  • Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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16 April 2009

Carbohydrate Derived Azides as Substrates for Cellobiose Phosphorylase from Clostridium Thermocellum

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Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Life Science, University of Vienna, Althanstraße 14, A-1090 Wien, Austria
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Abstract

Cellobiose phosphorylase from Clostridium thermocellum was examined for its ability to catalyze the synthesis of cellobiose derivatives with glucose-1-phosphate as the donor and azido analogues of glucose as acceptors. We have prepared the 2-azido-2-deoxy, 3-azido-3-deoxy and 6-azido-6-deoxy analogues of glucose as analogues of the reducing glucose moiety, as well as the diastereoisomer allose with a view to producing novel oligosaccharides for pharmaceutical applications.

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