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Sci. Pharm.
Volume 78
Issue 3
10.3797/scipharm.1004-21
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Article

Production, Quality Control and Pharmacokinetic Studies of 166Ho-EDTMP for Therapeutic Applications

by
Ali BAHRAMI-SAMANI
1,
Reza BAGHERI
2,
Amir R. JALILIAN
1,*,
Simindokht SHIRVANI-ARAni
1,
Mohammad GHANNADI-MARAGHEH
1 and
Mojtaba SHAMSAEE
2
1
Radiopharmaceutical Research and Development Lab (RRDL), Nuclear Science and Technology Research Institute (NSTRI), Tehran, Postal code: 14155-1339, Iran
2
Faculty of Nuclear Engineering and Physics, Amir Kabir University, Tehran, Iran
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2010, 78(3), 423-434; https://doi.org/10.3797/scipharm.1004-21
Submission received: 26 April 2010 / Accepted: 9 June 2010 / Published: 9 June 2010
Versions Notes

Abstract

166Ho-EDTMP is a major therapeutic agent which is widely used in bone palliation therapy. In this study, a 166Ho-EDTMP complex was prepared successfully using an in-house synthesized EDTMP ligand and 166HoCl3. Ho-166 chloride was obtained by thermal neutron irradiation (1 × 1013 ncm−2s−1) of natural Ho(NO3)3 samples (specific activity = 3–5 GBq/mg), dissolved in acidic media. The radiochemical purity of 166Ho-EDTMP was checked by ITLC (>99%) and stability studies in presence of human serum and final preparation were performed. The biodistribution of 166Ho-EDTMP and 166HoCl3 in wild-type rats was checked by scarification. SPECT imaging of 166Ho-EDTMP was also performed in wild-type rats. A comparative accumulation study for 166Ho-EDTMP and 166HoCl3 was performed for vital organs up to 48h. Significant bone accumulation (>70%) of the tracer in 48h was observed.
Keywords: Holmium-166; EDTMP; Radiopharmaceutical therapy; Biokinetic Holmium-166; EDTMP; Radiopharmaceutical therapy; Biokinetic

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MDPI and ACS Style

BAHRAMI-SAMANI, A.; BAGHERI, R.; JALILIAN, A.R.; SHIRVANI-ARAni, S.; GHANNADI-MARAGHEH, M.; SHAMSAEE, M. Production, Quality Control and Pharmacokinetic Studies of 166Ho-EDTMP for Therapeutic Applications. Sci. Pharm. 2010, 78, 423-434. https://doi.org/10.3797/scipharm.1004-21

AMA Style

BAHRAMI-SAMANI A, BAGHERI R, JALILIAN AR, SHIRVANI-ARAni S, GHANNADI-MARAGHEH M, SHAMSAEE M. Production, Quality Control and Pharmacokinetic Studies of 166Ho-EDTMP for Therapeutic Applications. Scientia Pharmaceutica. 2010; 78(3):423-434. https://doi.org/10.3797/scipharm.1004-21

Chicago/Turabian Style

BAHRAMI-SAMANI, Ali, Reza BAGHERI, Amir R. JALILIAN, Simindokht SHIRVANI-ARAni, Mohammad GHANNADI-MARAGHEH, and Mojtaba SHAMSAEE. 2010. "Production, Quality Control and Pharmacokinetic Studies of 166Ho-EDTMP for Therapeutic Applications" Scientia Pharmaceutica 78, no. 3: 423-434. https://doi.org/10.3797/scipharm.1004-21

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