A Coupled Kinetic-Dynamic Model Characterising Cell Cycle Response to an Anti-Cancer Agent

M. I. ATARI; M. J. CHAPPELL; R. J. ERRINGTON; P. J. SMITH; N. D. EVANS

doi:10.3797/scipharm.cespt.8.POT03

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12 July 2010

A Coupled Kinetic-Dynamic Model Characterising Cell Cycle Response to an Anti-Cancer Agent

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School of Engineering, University of Warwick, Coventry, United Kingdom

University of Wales College of Medicine, Cardiff University, Cardiff, United Kingdom

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Sci. Pharm.2010, 78(3), 718;https://doi.org/10.3797/scipharm.cespt.8.POT03

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Abstract

Topotecan (TPT) is a semi-synthetic derivative of the natural extract camptothecin, which has been found to act as an inhibitor of the DNA enzyme topoisomerase I in a specific and reversible fashion. [...]

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