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Sci. Pharm.Scientia Pharmaceutica
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  • Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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12 July 2010

Compartmental Modelling of the Pharmacokinetics of an Efflux Transporter

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and
1
School of Engineering, Warwick University, Coventry, United Kingdom
2
AstraZeneca R&D, Alderley Park, Cheshire, United Kingdom
*
Author to whom correspondence should be addressed.
Sci. Pharm.2010, 78(3), 727-728;https://doi.org/10.3797/scipharm.cespt.8.POT12
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Abstract

A mathematical model has been developed describing the pharmacokinetics of Hoechst 33342 following administration into a culture medium containing a population of transfected cells (HEK293 hBCRP) with a potent inhibitor of the BCRP, Fumitremorgin C (FTC), present. [...]

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