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Communication
Peer-Review Record

Estrogen Receptor beta (ERβ) Regulation of Lipid Homeostasis—Does Sex Matter?

Metabolites 2020, 10(3), 116; https://doi.org/10.3390/metabo10030116
by Christina Savva 1,2 and Marion Korach-André 1,2,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Metabolites 2020, 10(3), 116; https://doi.org/10.3390/metabo10030116
Submission received: 27 February 2020 / Accepted: 18 March 2020 / Published: 20 March 2020
(This article belongs to the Special Issue Insulin Resistance and Metabolic Disease: Mitochondria and Beyond)

Round 1

Reviewer 1 Report

This interesting short review is concise and well referenced. The subject is important and sex difference may lead to new therapies in obesity treatment. Redistribution of fat in obesity without weight loss may lead to a change is atheroma risk.  Increasing the amount of brown or beige fat may be a pathway to stimulation of this type of fat to increase thermogenesis and energy consumption and thus  stimulate weight loss.  This paper discusses these issues with reference to mostly animal and some human experiments.  The paper is well written and well referenced.

 

 

Reviewer 2 Report

The manuscript “Estrogen receptor beta (ERβ) regulation of lipid 2 homeostasis. Does sex matter?” by Christina Savva and Marion Korach-André submitted to Metabolites, is a short communication that aims to give an overview of the role of extrogen receptor betab in lipid metabolism with particular attention to the sex differences.

The paper is well organized and data are clearly described. I think that the manuscript fulfils the aims and it can be accepted for publication in the present form.

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