The Lipolysome—A Highly Complex and Dynamic Protein Network Orchestrating Cytoplasmic Triacylglycerol Degradation
Abstract
:1. Introduction
2. ATGL and Its Interaction Partners
2.1. Alpha/Beta-Hydrolase Domain Containing Protein 5 (ABHD5)
2.2. Perilipins (PLINs)
2.3. G0/G1 Switch Gene 2 (G0S2)
2.4. Hypoxia-Inducible LD-Associated Protein (HILPDA)
2.5. Fat-Specific Protein-27 (FSP-27)
2.6. Pigment Epithelium-Derived Factor (PEDF)
2.7. Ubiquitin Regulatory X Domain-Containing Protein 8 (UBXD8)
2.8. Golgi Brefeldin a Resistance Factor 1 (GBF1)
2.9. 14-3-3
2.10. Peroxisome Biogenesis Factor 5 (PEX5)
3. HSL and Its Interaction Partners
3.1. FABPs
3.2. PLINs
3.3. Vimentin (VIM)
3.4. Cavin-1
3.5. Carbohydrate Response Element Binding Protein (ChREBP)
3.6. Microtubule-Associated Proteins 1A/1B Light Chain 3B (LC3)
3.7. Steroidogenic Acute Regulatory Protein (StAR)
4. MGL and Its Interaction Partners
5. Conclusions and Outlook
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
2-AG | 2-arachidonoyl glycerol |
AMPK | 5’ adenosine monophosphate-activated protein kinase |
ABHD5 | alpha/beta-hydrolase domain containing protein 5 |
ADP | adenosine-diphosphate |
ADRP | adipose differentiation related protein |
ARF-1 | ADP-ribosylation factor 1 |
AT | adipose tissue |
ATGL | adipose triglyceride lipase |
ATP | adenosine-triphosphate |
Bcl2 | B-Cell CLL/Lymphoma 2 |
cAMP | cyclic adenosine monophosphate |
CBRs | cannabinoid receptors |
CE | cholesteryl ester |
CGI-58 | comparative gene identification-58 |
CHGB | chromogranin B |
ChREBP | carbohydrate response element binding protein |
CIDEC | cell death-inducing DNA fragment factor 40/45-like effector C |
CL 316,243 | β3 adrenoceptor agonist |
COPI | coatomer protein I |
DAG | diacylglycerol |
DNL | de novo lipogenesis |
ELOVL6; | elongase of long chain fatty acids family 6 |
ER | endoplasmic reticulum |
ERK | extracellular signal-regulated kinase |
FA | fatty acid |
FABP | fatty acid-binding protein |
FSP-27 | fat-specific protein-27 |
G0S2 | G0/G1 switch gene 2 |
GBF1 | Golgi Brefeldin A resistance factor 1 |
GH | growth hormone |
HIG-2 | hypoxia-inducible gene-2 |
HILPDA | hypoxia-inducible LD-associated protein |
HSL | hormone-sensitive lipase |
IC50 | half maximal inhibitory concentration |
iPLA2-zeta | Ca2+-independent phospholipase A2-zeta |
KIFC3 | Kinesin Family Member C3 |
KO | knockout |
LC3 | microtubule-associated proteins 1A/1B light chain 3B |
LC3-interacting region | LC3-interacting region |
LD | lipid droplet |
MAG | monoacylglycerol |
MGL | MAG lipase |
NCL | nucleolin |
NLSD-M/-I | neutral lipid storage disease with myopathy/with ichthyosis |
p97/VCP | partner p97 subunit/valosin containing protein |
PAT | perilipin/ADRP/TIP47 |
PEDF | pigment epithelium-derived factor |
PEX5 | peroxisome biogenesis factor 5 |
PKA | protein kinase A |
PLIN | perilipin |
PNPLA | patatin-like phospholipase domain containing |
PPAR | peroxisome proliferator-activated receptor |
PTRF | polymerase I and transcript release factor |
PTS1R | peroxisome target sequence 1 receptor protein |
RNA | ribonucleic acid |
RNAi | RNA interference |
SND1 | Staphylococcal nuclease and tudor domain containing 1 |
StAR | steroidogenic acute regulatory protein |
TAG | triacylglycerol |
TIP-47 | tail-interacting protein of 47 kDa |
UBXD8 | ubiquitin regulatory X domain-containing protein 8 |
VIM | Vimentin |
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Hofer, P.; Taschler, U.; Schreiber, R.; Kotzbeck, P.; Schoiswohl, G. The Lipolysome—A Highly Complex and Dynamic Protein Network Orchestrating Cytoplasmic Triacylglycerol Degradation. Metabolites 2020, 10, 147. https://doi.org/10.3390/metabo10040147
Hofer P, Taschler U, Schreiber R, Kotzbeck P, Schoiswohl G. The Lipolysome—A Highly Complex and Dynamic Protein Network Orchestrating Cytoplasmic Triacylglycerol Degradation. Metabolites. 2020; 10(4):147. https://doi.org/10.3390/metabo10040147
Chicago/Turabian StyleHofer, Peter, Ulrike Taschler, Renate Schreiber, Petra Kotzbeck, and Gabriele Schoiswohl. 2020. "The Lipolysome—A Highly Complex and Dynamic Protein Network Orchestrating Cytoplasmic Triacylglycerol Degradation" Metabolites 10, no. 4: 147. https://doi.org/10.3390/metabo10040147