Drosophila INDY and Mammalian INDY: Major Differences in Transport Mechanism and Structural Features despite Mostly Similar Biological Functions
, Sathish Sivaprakasam 2, Vadivel Ganapathy 2 and Ina L. Urbatsch 2,*Round 1
Reviewer 1 Report
The studies of evolutionarily conserved longevity pathways are crucial for the translation of anti-aging interventions from model organisms to clinical practice. This review makes a significant contribution to understanding the functions of the aging-related INDY gene in flies and humans.
Reviewer 2 Report
The review by Jaramillo-Martinez et al. is a well-written comprehensive review that discusses the similarities and differences of transporting characteristics, and structure between plasma membrane citrate transporter INDY/SLC13A5 in Drosophila and its mammalian orthologue mINDY/mSLC13A5/NaCT. The authors provided explanations/suggestions for some of the species-specific differences in effects of reduced levels of the Indy gene activity in flies (Indy) and mammals (NaCT/mSLC13A5/mIndy).
Reviewer 3 Report
In the review article titled "Drosophila INDY and mammalian INDY: Major differences in 2 transport mechanism and structural features despite mostly similar biological functions" the authors describe the structural and functional features of INDY gene and compare drosophila and human expressed Indy proteins. I don't have any major issues with the content of the review and would recommend it for publication. I would ask the authors to go over editing the different section titles.
