The Effects of Fasting or Ketogenic Diet on Endurance Exercise Performance and Metabolism in Female Mice
Abstract
:1. Introduction
2. Results
2.1. Fasting Induces Physiological Ketosis but Does Not Improve Endurance Exercise Capacity
2.2. Fasting Does Not Alter Endogenous Triacylglycerol or Glycogen Content in the Heart, Gastrocnemius, or Liver
2.3. Short-Term Ketogenic Diet Increases Weight Gain and Adiposity
2.4. Short-Term Ketogenic Diet Elevates Serum Ketone Bodies and Total Cholesterol
2.5. Short-Term Ketogenic Diet Depletes Glycogen and Increases Tissue Triglycerides
2.6. Short-Term Ketogenic Diet Alters Gene Expression in the Heart, Skeletal Muscle, and Liver
3. Discussion
4. Materials and Methods
4.1. Animals
4.2. Composition of Diet
4.3. Serum Analyses
4.4. Endurance Exercise Capacity Tests
4.5. Gravimetric Analysis
4.6. Biochemical Analysis in Tissues
4.7. Analysis of Gene Expression
4.8. Statistical Analysis
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Holcomb, L.E.; O’Neill, C.C.; DeWitt, E.A.; Kolwicz, S.C., Jr. The Effects of Fasting or Ketogenic Diet on Endurance Exercise Performance and Metabolism in Female Mice. Metabolites 2021, 11, 397. https://doi.org/10.3390/metabo11060397
Holcomb LE, O’Neill CC, DeWitt EA, Kolwicz SC Jr. The Effects of Fasting or Ketogenic Diet on Endurance Exercise Performance and Metabolism in Female Mice. Metabolites. 2021; 11(6):397. https://doi.org/10.3390/metabo11060397
Chicago/Turabian StyleHolcomb, Lola E., Caitlin C. O’Neill, Elizabeth A. DeWitt, and Stephen C. Kolwicz, Jr. 2021. "The Effects of Fasting or Ketogenic Diet on Endurance Exercise Performance and Metabolism in Female Mice" Metabolites 11, no. 6: 397. https://doi.org/10.3390/metabo11060397