Brain-Derived Neurotrophic Factor in Gestational Diabetes: Analysis of Maternal Serum and Cord Blood Pairs and Comparison of Dietary- and Insulin-Dependent GDM
, Anna Katharina Diedrich 1, Alexandru Odainic 2,3, Susanne Viktoria Schmidt 2, Marie-Therese Schmitz 4, Brigitte Strizek 1, Ulrich Gembruch 1, Waltraut Maria Merz 1 and Anne Flöck 1,*
Round 1
Reviewer 1 Report
The current paper represents original author contribution focused on influence of gestational diabetes (GDM) on BDNF blood levels of corresponding maternal-neonatal pairs. The study design was prospective and different from previously conducted in context of maternal-neonatal pairs. If it is possible it might be interesting to add maternal metabolic parameters if they are available (maybe glucose values from 2h OGTT).
Author Response
- Reviewer 1: “If it is possible it might be interesting to add maternal metabolic parameters….. (maybe glucose values from 2h OGTT)”
ïƒ Unfortunately, we cannot provide these data. Routine oral glucose tolerance testing at 24 - 28 weeks of gestation is non-uniform in Germany and in our patients. Test were done in resident doctors practices even with non-fasting 50g oral glucose challenge test followed by a 75g oral glucose tolerance testing (OGTT) if suspect, or only 75g OGTT, respectively
Author Response File: 
Author Response.docx
Reviewer 2 Report
Dear Author
The study is interesting and deserves consideration in this journal.
The english needs revision for typos and grammar.
I suggest to add a little discussion on the influence of hormones such as neuropeptides in brain derived fuctors and diabetes, for example kiss-peptin and RVD hemopressin; look at the following recent literature es example: "Effects of Kisspeptin-10 on Hypothalamic Neuropeptides and Neurotransmitters Involved in Appetite Control", "Anorexigenic effects induced by RVD-hemopressin(α) administration", "Emotional disorders induced by Hemopressin and RVD-hemopressin(α) administration in rats".
Author Response
- Reviewer 2:
“The english needs revision for typos and grammar”
ïƒ The manuscript was revised by a native speaker, grammar and typing mistakes were corrected.
“I suggest to add a little discussion on the influence of hormones such as neuropeptides in brain derived functions and diabetes, for example kisspeptin and RVD-hemopressin; …”
ïƒ We added a short discussion on the topic in the discussion section 3.2 BDNF in GDM, see lines 240-255. Accordingly, we added four new reference (36-39).
Author Response File: Author Response.docx
